S14L4_HUMAN
ID S14L4_HUMAN Reviewed; 406 AA.
AC Q9UDX3; A5D6W7; A6NCV4;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=SEC14-like protein 4;
DE AltName: Full=Tocopherol-associated protein 3;
GN Name=SEC14L4; Synonyms=TAP3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=12757856; DOI=10.1016/s0891-5849(03)00173-4;
RA Kempna P., Zingg J.-M., Ricciarelli R., Hierl M., Saxena S., Azzi A.;
RT "Cloning of novel human SEC14p-like proteins: ligand binding and functional
RT properties.";
RL Free Radic. Biol. Med. 34:1458-1472(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: Probable hydrophobic ligand-binding protein; may play a role
CC in the transport of hydrophobic ligands like tocopherol, squalene and
CC phospholipids.
CC -!- INTERACTION:
CC Q9UDX3; Q96LC9: BMF; NbExp=3; IntAct=EBI-10320311, EBI-3919268;
CC Q9UDX3; O43186: CRX; NbExp=3; IntAct=EBI-10320311, EBI-748171;
CC Q9UDX3; P78358: CTAG1B; NbExp=3; IntAct=EBI-10320311, EBI-1188472;
CC Q9UDX3; Q9NYQ3: HAO2; NbExp=3; IntAct=EBI-10320311, EBI-8803200;
CC Q9UDX3; Q0VD86: INCA1; NbExp=3; IntAct=EBI-10320311, EBI-6509505;
CC Q9UDX3; Q15323: KRT31; NbExp=3; IntAct=EBI-10320311, EBI-948001;
CC Q9UDX3; O76011: KRT34; NbExp=3; IntAct=EBI-10320311, EBI-1047093;
CC Q9UDX3; P50221: MEOX1; NbExp=3; IntAct=EBI-10320311, EBI-2864512;
CC Q9UDX3; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-10320311, EBI-16439278;
CC Q9UDX3; Q02548: PAX5; NbExp=3; IntAct=EBI-10320311, EBI-296331;
CC Q9UDX3; P26367: PAX6; NbExp=3; IntAct=EBI-10320311, EBI-747278;
CC Q9UDX3; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-10320311, EBI-742388;
CC Q9UDX3; Q04864: REL; NbExp=3; IntAct=EBI-10320311, EBI-307352;
CC Q9UDX3; Q04864-2: REL; NbExp=3; IntAct=EBI-10320311, EBI-10829018;
CC Q9UDX3; Q9UHV2: SERTAD1; NbExp=3; IntAct=EBI-10320311, EBI-748601;
CC Q9UDX3; P15884: TCF4; NbExp=3; IntAct=EBI-10320311, EBI-533224;
CC Q9UDX3; P15884-3: TCF4; NbExp=3; IntAct=EBI-10320311, EBI-13636688;
CC Q9UDX3; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-10320311, EBI-11139477;
CC Q9UDX3; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-10320311, EBI-2130429;
CC Q9UDX3; Q8N6Y0: USHBP1; NbExp=6; IntAct=EBI-10320311, EBI-739895;
CC Q9UDX3; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-10320311, EBI-12030590;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9UDX3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UDX3-2; Sequence=VSP_045200;
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DR EMBL; AY158085; AAO21869.1; -; mRNA.
DR EMBL; AC004832; AAF19259.1; -; Genomic_DNA.
DR EMBL; BC139912; AAI39913.1; -; mRNA.
DR CCDS; CCDS13878.1; -. [Q9UDX3-1]
DR CCDS; CCDS54517.1; -. [Q9UDX3-2]
DR RefSeq; NP_001154840.1; NM_001161368.1. [Q9UDX3-2]
DR RefSeq; NP_777637.1; NM_174977.3. [Q9UDX3-1]
DR PDB; 4TLG; X-ray; 1.77 A; A/B=1-406.
DR PDBsum; 4TLG; -.
DR AlphaFoldDB; Q9UDX3; -.
DR SMR; Q9UDX3; -.
DR BioGRID; 129974; 23.
DR IntAct; Q9UDX3; 20.
DR STRING; 9606.ENSP00000255858; -.
DR DrugBank; DB14003; alpha-Tocopherol acetate.
DR DrugBank; DB11635; Tocofersolan.
DR DrugBank; DB11251; Tocopherol.
DR DrugBank; DB00163; Vitamin E.
DR iPTMnet; Q9UDX3; -.
DR PhosphoSitePlus; Q9UDX3; -.
DR BioMuta; SEC14L4; -.
DR DMDM; 29337003; -.
DR EPD; Q9UDX3; -.
DR jPOST; Q9UDX3; -.
DR MassIVE; Q9UDX3; -.
DR MaxQB; Q9UDX3; -.
DR PaxDb; Q9UDX3; -.
DR PeptideAtlas; Q9UDX3; -.
DR PRIDE; Q9UDX3; -.
DR ProteomicsDB; 709; -.
DR ProteomicsDB; 84123; -. [Q9UDX3-1]
DR Antibodypedia; 45388; 113 antibodies from 21 providers.
DR DNASU; 284904; -.
DR Ensembl; ENST00000255858.12; ENSP00000255858.7; ENSG00000133488.15. [Q9UDX3-1]
DR Ensembl; ENST00000381982.3; ENSP00000371412.3; ENSG00000133488.15. [Q9UDX3-2]
DR GeneID; 284904; -.
DR KEGG; hsa:284904; -.
DR MANE-Select; ENST00000255858.12; ENSP00000255858.7; NM_174977.4; NP_777637.1.
DR UCSC; uc003aid.4; human. [Q9UDX3-1]
DR CTD; 284904; -.
DR DisGeNET; 284904; -.
DR GeneCards; SEC14L4; -.
DR HGNC; HGNC:20627; SEC14L4.
DR HPA; ENSG00000133488; Tissue enhanced (bone marrow, liver).
DR MIM; 612825; gene.
DR neXtProt; NX_Q9UDX3; -.
DR OpenTargets; ENSG00000133488; -.
DR PharmGKB; PA134979694; -.
DR VEuPathDB; HostDB:ENSG00000133488; -.
DR eggNOG; KOG1471; Eukaryota.
DR GeneTree; ENSGT00940000162471; -.
DR HOGENOM; CLU_014001_2_1_1; -.
DR InParanoid; Q9UDX3; -.
DR OMA; LMIWGGK; -.
DR OrthoDB; 1133487at2759; -.
DR PhylomeDB; Q9UDX3; -.
DR TreeFam; TF313988; -.
DR PathwayCommons; Q9UDX3; -.
DR SignaLink; Q9UDX3; -.
DR BioGRID-ORCS; 284904; 12 hits in 1077 CRISPR screens.
DR ChiTaRS; SEC14L4; human.
DR GenomeRNAi; 284904; -.
DR Pharos; Q9UDX3; Tbio.
DR PRO; PR:Q9UDX3; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9UDX3; protein.
DR Bgee; ENSG00000133488; Expressed in buccal mucosa cell and 79 other tissues.
DR ExpressionAtlas; Q9UDX3; baseline and differential.
DR Genevisible; Q9UDX3; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; -; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011074; CRAL/TRIO_N_dom.
DR InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR Pfam; PF00650; CRAL_TRIO; 1.
DR SMART; SM01100; CRAL_TRIO_N; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF101576; SSF101576; 1.
DR SUPFAM; SSF46938; SSF46938; 1.
DR SUPFAM; SSF52087; SSF52087; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Lipid-binding; Reference proteome;
KW Transport.
FT CHAIN 1..406
FT /note="SEC14-like protein 4"
FT /id="PRO_0000210760"
FT DOMAIN 76..249
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT DOMAIN 252..383
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT VAR_SEQ 361..406
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_045200"
FT VARIANT 3
FT /note="S -> G (in dbSNP:rs9608956)"
FT /id="VAR_024629"
FT VARIANT 124
FT /note="R -> G (in dbSNP:rs9606739)"
FT /id="VAR_051914"
FT VARIANT 200
FT /note="V -> M (in dbSNP:rs17738540)"
FT /id="VAR_051915"
FT VARIANT 211
FT /note="E -> K (in dbSNP:rs17738527)"
FT /id="VAR_051916"
FT HELIX 10..22
FT /evidence="ECO:0007829|PDB:4TLG"
FT TURN 23..26
FT /evidence="ECO:0007829|PDB:4TLG"
FT HELIX 27..29
FT /evidence="ECO:0007829|PDB:4TLG"
FT HELIX 35..44
FT /evidence="ECO:0007829|PDB:4TLG"
FT TURN 45..47
FT /evidence="ECO:0007829|PDB:4TLG"
FT HELIX 49..65
FT /evidence="ECO:0007829|PDB:4TLG"
FT HELIX 68..73
FT /evidence="ECO:0007829|PDB:4TLG"
FT HELIX 78..83
FT /evidence="ECO:0007829|PDB:4TLG"
FT STRAND 86..91
FT /evidence="ECO:0007829|PDB:4TLG"
FT STRAND 97..101
FT /evidence="ECO:0007829|PDB:4TLG"
FT HELIX 108..114
FT /evidence="ECO:0007829|PDB:4TLG"
FT HELIX 117..142
FT /evidence="ECO:0007829|PDB:4TLG"
FT STRAND 149..154
FT /evidence="ECO:0007829|PDB:4TLG"
FT HELIX 160..163
FT /evidence="ECO:0007829|PDB:4TLG"
FT HELIX 165..181
FT /evidence="ECO:0007829|PDB:4TLG"
FT STRAND 186..193
FT /evidence="ECO:0007829|PDB:4TLG"
FT HELIX 198..205
FT /evidence="ECO:0007829|PDB:4TLG"
FT HELIX 206..208
FT /evidence="ECO:0007829|PDB:4TLG"
FT HELIX 211..215
FT /evidence="ECO:0007829|PDB:4TLG"
FT STRAND 217..219
FT /evidence="ECO:0007829|PDB:4TLG"
FT HELIX 224..228
FT /evidence="ECO:0007829|PDB:4TLG"
FT TURN 229..231
FT /evidence="ECO:0007829|PDB:4TLG"
FT HELIX 234..236
FT /evidence="ECO:0007829|PDB:4TLG"
FT HELIX 239..241
FT /evidence="ECO:0007829|PDB:4TLG"
FT STRAND 243..245
FT /evidence="ECO:0007829|PDB:4TLG"
FT TURN 255..257
FT /evidence="ECO:0007829|PDB:4TLG"
FT HELIX 266..268
FT /evidence="ECO:0007829|PDB:4TLG"
FT STRAND 279..284
FT /evidence="ECO:0007829|PDB:4TLG"
FT STRAND 289..296
FT /evidence="ECO:0007829|PDB:4TLG"
FT STRAND 302..312
FT /evidence="ECO:0007829|PDB:4TLG"
FT STRAND 314..320
FT /evidence="ECO:0007829|PDB:4TLG"
FT STRAND 322..326
FT /evidence="ECO:0007829|PDB:4TLG"
FT TURN 330..332
FT /evidence="ECO:0007829|PDB:4TLG"
FT STRAND 333..342
FT /evidence="ECO:0007829|PDB:4TLG"
FT TURN 344..346
FT /evidence="ECO:0007829|PDB:4TLG"
FT STRAND 349..354
FT /evidence="ECO:0007829|PDB:4TLG"
FT STRAND 357..366
FT /evidence="ECO:0007829|PDB:4TLG"
FT STRAND 375..384
FT /evidence="ECO:0007829|PDB:4TLG"
FT HELIX 388..396
FT /evidence="ECO:0007829|PDB:4TLG"
SQ SEQUENCE 406 AA; 46644 MW; 7C8763DDA202EB5A CRC64;
MSSRVGDLSP QQQEALARFR ENLQDLLPIL PNADDYFLLR WLRARNFDLQ KSEDMLRRHM
EFRKQQDLDN IVTWQPPEVI QLYDSGGLCG YDYEGCPVYF NIIGSLDPKG LLLSASKQDM
IRKRIKVCEL LLHECELQTQ KLGRKIEMAL MVFDMEGLSL KHLWKPAVEV YQQFFSILEA
NYPETLKNLI VIRAPKLFPV AFNLVKSFMS EETRRKIVIL GDNWKQELTK FISPDQLPVE
FGGTMTDPDG NPKCLTKINY GGEVPKSYYL CEQVRLQYEH TRSVGRGSSL QVENEILFPG
CVLRWQFASD GGDIGFGVFL KTKMGEQQSA REMTEVLPSQ RYNAHMVPED GSLTCLQAGV
YVLRFDNTYS RMHAKKLSYT VEVLLPDKAS EETLQSLKAM RPSPTQ
