ID   S14L4_MOUSE             Reviewed;         403 AA.
AC   Q8R0F9;
DT   25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=SEC14-like protein 4;
GN   Name=Sec14l4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Liver, Lung, and Pancreas;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Probable hydrophobic ligand-binding protein; may play a role
CC       in the transport of hydrophobic ligands like tocopherol, squalene and
CC       phospholipids. {ECO:0000250}.
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DR   EMBL; BC026948; AAH26948.1; -; mRNA.
DR   CCDS; CCDS24374.1; -.
DR   RefSeq; NP_666125.1; NM_146013.1.
DR   AlphaFoldDB; Q8R0F9; -.
DR   SMR; Q8R0F9; -.
DR   BioGRID; 222134; 1.
DR   STRING; 10090.ENSMUSP00000019512; -.
DR   iPTMnet; Q8R0F9; -.
DR   PhosphoSitePlus; Q8R0F9; -.
DR   SwissPalm; Q8R0F9; -.
DR   jPOST; Q8R0F9; -.
DR   MaxQB; Q8R0F9; -.
DR   PaxDb; Q8R0F9; -.
DR   PeptideAtlas; Q8R0F9; -.
DR   PRIDE; Q8R0F9; -.
DR   ProteomicsDB; 253350; -.
DR   Antibodypedia; 45388; 113 antibodies from 21 providers.
DR   DNASU; 103655; -.
DR   Ensembl; ENSMUST00000019512; ENSMUSP00000019512; ENSMUSG00000019368.
DR   GeneID; 103655; -.
DR   KEGG; mmu:103655; -.
DR   UCSC; uc007hue.1; mouse.
DR   CTD; 284904; -.
DR   MGI; MGI:2144095; Sec14l4.
DR   VEuPathDB; HostDB:ENSMUSG00000019368; -.
DR   eggNOG; KOG1471; Eukaryota.
DR   GeneTree; ENSGT00940000162471; -.
DR   HOGENOM; CLU_014001_2_1_1; -.
DR   InParanoid; Q8R0F9; -.
DR   OMA; LMIWGGK; -.
DR   OrthoDB; 1133487at2759; -.
DR   PhylomeDB; Q8R0F9; -.
DR   TreeFam; TF313988; -.
DR   BioGRID-ORCS; 103655; 2 hits in 77 CRISPR screens.
DR   ChiTaRS; Sec14l4; mouse.
DR   PRO; PR:Q8R0F9; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8R0F9; protein.
DR   Bgee; ENSMUSG00000019368; Expressed in lip and 54 other tissues.
DR   Genevisible; Q8R0F9; MM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; -; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011074; CRAL/TRIO_N_dom.
DR   InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR   InterPro; IPR009038; GOLD_dom.
DR   InterPro; IPR036598; GOLD_dom_sf.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   SMART; SM01100; CRAL_TRIO_N; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF101576; SSF101576; 1.
DR   SUPFAM; SSF46938; SSF46938; 1.
DR   SUPFAM; SSF52087; SSF52087; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS50866; GOLD; 1.
PE   1: Evidence at protein level;
KW   Lipid-binding; Reference proteome; Transport.
FT   CHAIN           1..403
FT                   /note="SEC14-like protein 4"
FT                   /id="PRO_0000210761"
FT   DOMAIN          76..249
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT   DOMAIN          275..383
FT                   /note="GOLD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
SQ   SEQUENCE   403 AA;  46053 MW;  5758BCD814EDE1D6 CRC64;
     MRGQVGDLSP QQQEALARFR ETLQDLLPTL PKADDYFLLR WLRARNFDLK KSEDMLRKHV
     EFRNQQNLDQ ILTWQAPEVI QLYDSGGLSG YDYEGCPVWF DIIGTMDPKG LFMSASKQDM
     IRKRIKVCEM LLHECELQSQ KLGRKIERMV MVFDMEGLSL RHLWKPAVEV YQQFFAILEA
     NYPETVKNLI IIRAPKLFPV AFNLVKSFMG EETQKKIVIL GGNWKQELVK FVSPDQLPVE
     FGGTMTDPDG NPKCLTKINY GGEVPKRYYL SNQERPQYEH SVVVGRGSSH QVENEILFPG
     CVLRWQFASD GGDIGFGVFL KTRMGERQKA GEMVEVLPSQ RYNAHMVPED GSLNCLKAGV
     YVLRFDNTYS LLHTKKVGYT AEVLLPDKAC EEKLQGLGSV SPP