ID   S14L5_HUMAN             Reviewed;         696 AA.
AC   O43304;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 3.
DT   03-AUG-2022, entry version 156.
DE   RecName: Full=SEC14-like protein 5;
GN   Name=SEC14L5; Synonyms=KIAA0420;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=9455477; DOI=10.1093/dnares/4.5.307;
RA   Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N.,
RA   Tanaka A., Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. VIII. 78
RT   new cDNA clones from brain which code for large proteins in vitro.";
RL   DNA Res. 4:307-313(1997).
RN   [2]
RP   SEQUENCE REVISION.
RX   PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA   Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT   "Construction of expression-ready cDNA clones for KIAA genes: manual
RT   curation of 330 KIAA cDNA clones.";
RL   DNA Res. 9:99-106(2002).
CC   -!- INTERACTION:
CC       O43304; P62333: PSMC6; NbExp=3; IntAct=EBI-12224055, EBI-357669;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA24850.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB007880; BAA24850.2; ALT_INIT; mRNA.
DR   CCDS; CCDS45403.1; -.
DR   RefSeq; NP_055507.1; NM_014692.1.
DR   AlphaFoldDB; O43304; -.
DR   SMR; O43304; -.
DR   BioGRID; 115066; 3.
DR   IntAct; O43304; 1.
DR   STRING; 9606.ENSP00000251170; -.
DR   iPTMnet; O43304; -.
DR   PhosphoSitePlus; O43304; -.
DR   BioMuta; SEC14L5; -.
DR   MassIVE; O43304; -.
DR   PaxDb; O43304; -.
DR   PeptideAtlas; O43304; -.
DR   PRIDE; O43304; -.
DR   ProteomicsDB; 48879; -.
DR   Antibodypedia; 51621; 69 antibodies from 12 providers.
DR   DNASU; 9717; -.
DR   Ensembl; ENST00000251170.12; ENSP00000251170.6; ENSG00000103184.12.
DR   GeneID; 9717; -.
DR   KEGG; hsa:9717; -.
DR   MANE-Select; ENST00000251170.12; ENSP00000251170.6; NM_014692.2; NP_055507.1.
DR   UCSC; uc002cye.3; human.
DR   CTD; 9717; -.
DR   DisGeNET; 9717; -.
DR   GeneCards; SEC14L5; -.
DR   HGNC; HGNC:29032; SEC14L5.
DR   HPA; ENSG00000103184; Tissue enriched (brain).
DR   MIM; 619412; gene.
DR   neXtProt; NX_O43304; -.
DR   OpenTargets; ENSG00000103184; -.
DR   PharmGKB; PA142670939; -.
DR   VEuPathDB; HostDB:ENSG00000103184; -.
DR   eggNOG; KOG1471; Eukaryota.
DR   GeneTree; ENSGT00940000160832; -.
DR   HOGENOM; CLU_023840_0_0_1; -.
DR   InParanoid; O43304; -.
DR   OMA; YHTKQVP; -.
DR   OrthoDB; 1133487at2759; -.
DR   PhylomeDB; O43304; -.
DR   TreeFam; TF313988; -.
DR   PathwayCommons; O43304; -.
DR   SignaLink; O43304; -.
DR   BioGRID-ORCS; 9717; 15 hits in 1071 CRISPR screens.
DR   ChiTaRS; SEC14L5; human.
DR   GenomeRNAi; 9717; -.
DR   Pharos; O43304; Tdark.
DR   PRO; PR:O43304; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; O43304; protein.
DR   Bgee; ENSG00000103184; Expressed in inferior vagus X ganglion and 133 other tissues.
DR   ExpressionAtlas; O43304; baseline and differential.
DR   Genevisible; O43304; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; -; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011074; CRAL/TRIO_N_dom.
DR   InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR   InterPro; IPR009038; GOLD_dom.
DR   InterPro; IPR036598; GOLD_dom_sf.
DR   InterPro; IPR006797; PRELI/MSF1_dom.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   Pfam; PF03765; CRAL_TRIO_N; 1.
DR   Pfam; PF04707; PRELI; 1.
DR   SMART; SM01100; CRAL_TRIO_N; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF101576; SSF101576; 1.
DR   SUPFAM; SSF46938; SSF46938; 1.
DR   SUPFAM; SSF52087; SSF52087; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS50866; GOLD; 1.
DR   PROSITE; PS50904; PRELI_MSF1; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..696
FT                   /note="SEC14-like protein 5"
FT                   /id="PRO_0000333865"
FT   DOMAIN          2..175
FT                   /note="PRELI/MSF1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00158"
FT   DOMAIN          306..482
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT   DOMAIN          509..653
FT                   /note="GOLD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT   REGION          178..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   696 AA;  78942 MW;  8C94913A7B221730 CRC64;
     MVQRYQSPVR VYKYPFELVM AAYEKRFPTC PQIPVFLGSE VLRESRSPDG AVHVVERSCR
     LRVDAPRLLR KIAGVEHVVF VQTNILNWKE RTLLIEAHNE TFANRVVVNE HCSYTVHPEN
     EDWTCFEQSA SLDIRSFFGF ENALEKIAMK QYTANVKRGK EVIEHYLNEL ISQGTSHIPR
     WTPAPVREED ARNQAGPRDP SSLEAHGPRS TLGPALEAVS MDGDKLDADY IERCLGHLTP
     MQESCLIQLR HWLQETHKGK IPKDEHILRF LRAHDFHLDK AREMLRQSLS WRKQHQVDLL
     LQTWQPPALL EEFYAGGWHY QDIDGRPLYI LRLGQMDTKG LMKAVGEEAL LRHVLSVNEE
     GQKRCEGSTR QLGRPISSWT CLLDLEGLNM RHLWRPGVKA LLRMIEVVED NYPETLGRLL
     IVRAPRVFPV LWTLISPFIN ENTRRKFLIY SGSNYQGPGG LVDYLDREVI PDFLGGESVC
     NVPEGGLVPK SLYMTEEEQE HTDQLWQWSE TYHSASVLRG APHEVAVEIL EGESVITWDF
     DILRGDVVFS LYHTKQAPRL GAREPGTRAS GQLIDKGWVL GRDYSRVEAP LVCREGESIQ
     GSHVTRWPGV YLLQWQMHSP PSSVACSLPG VDDVLTALHS PGPKCKLLYY CEVLASEDFR
     GSMSSLESCT SGFSQLSAAT SSSSSGQSHS SSLVSR