S14L6_HUMAN
ID S14L6_HUMAN Reviewed; 397 AA.
AC B5MCN3;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Putative SEC14-like protein 6;
GN Name=SEC14L6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
CC -!- CAUTION: Product of a dubious gene prediction. {ECO:0000305}.
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DR EMBL; AC004832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS54518.1; -.
DR RefSeq; NP_001180265.2; NM_001193336.2.
DR AlphaFoldDB; B5MCN3; -.
DR SMR; B5MCN3; -.
DR STRING; 9606.ENSP00000385695; -.
DR iPTMnet; B5MCN3; -.
DR PhosphoSitePlus; B5MCN3; -.
DR BioMuta; SEC14L6; -.
DR jPOST; B5MCN3; -.
DR MassIVE; B5MCN3; -.
DR MaxQB; B5MCN3; -.
DR PaxDb; B5MCN3; -.
DR PeptideAtlas; B5MCN3; -.
DR PRIDE; B5MCN3; -.
DR ProteomicsDB; 6075; -.
DR Antibodypedia; 77781; 4 antibodies from 4 providers.
DR DNASU; 730005; -.
DR Ensembl; ENST00000402034.7; ENSP00000385695.1; ENSG00000214491.9.
DR GeneID; 730005; -.
DR KEGG; hsa:730005; -.
DR MANE-Select; ENST00000402034.7; ENSP00000385695.1; NM_001193336.4; NP_001180265.2.
DR UCSC; uc021wnu.2; human.
DR CTD; 730005; -.
DR DisGeNET; 730005; -.
DR GeneCards; SEC14L6; -.
DR HGNC; HGNC:40047; SEC14L6.
DR HPA; ENSG00000214491; Tissue enhanced (epididymis, parathyroid gland).
DR neXtProt; NX_B5MCN3; -.
DR OpenTargets; ENSG00000214491; -.
DR VEuPathDB; HostDB:ENSG00000214491; -.
DR eggNOG; KOG1471; Eukaryota.
DR GeneTree; ENSGT00940000165472; -.
DR HOGENOM; CLU_014001_2_1_1; -.
DR InParanoid; B5MCN3; -.
DR OMA; GLCHCEG; -.
DR OrthoDB; 1133487at2759; -.
DR PhylomeDB; B5MCN3; -.
DR TreeFam; TF313988; -.
DR PathwayCommons; B5MCN3; -.
DR BioGRID-ORCS; 730005; 10 hits in 1066 CRISPR screens.
DR ChiTaRS; SEC14L6; human.
DR GenomeRNAi; 730005; -.
DR Pharos; B5MCN3; Tdark.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; B5MCN3; protein.
DR Bgee; ENSG00000214491; Expressed in metanephros cortex and 92 other tissues.
DR ExpressionAtlas; B5MCN3; baseline and differential.
DR Genevisible; B5MCN3; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; -; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011074; CRAL/TRIO_N_dom.
DR InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR Pfam; PF00650; CRAL_TRIO; 1.
DR SMART; SM01100; CRAL_TRIO_N; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF101576; SSF101576; 1.
DR SUPFAM; SSF46938; SSF46938; 1.
DR SUPFAM; SSF52087; SSF52087; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 5: Uncertain;
KW Reference proteome.
FT CHAIN 1..397
FT /note="Putative SEC14-like protein 6"
FT /id="PRO_0000410725"
FT DOMAIN 76..249
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT DOMAIN 252..383
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
SQ SEQUENCE 397 AA; 45364 MW; BB45CFE2EA9CBB81 CRC64;
MSGQVGDLSP SQEKSLAQFR ENIQDVLSAL PNPDDYFLLR WLQARSFDLQ KSEDMLRKHM
EFRKQQDLAN ILAWQPPEVV RLYNANGICG HDGEGSPVWY HIVGSLDPKG LLLSASKQEL
LRDSFRSCEL LLRECELQSQ KLGKRVEKII AIFGLEGLGL RDLWKPGIEL LQEFFSALEA
NYPEILKSLI VVRAPKLFAV AFNLVKSYMS EETRRKVVIL GDNWKQELTK FISPDQLPVE
FGGTMTDPDG NPKCLTKINY GGEVPKSYYL CKQVRLQYEH TRSVGRGSSL QVENEILFPG
CVLRWQFASD GGDIGFGVFL KTKMGERQRA REMTEVLPSQ RYNAHMVPED GILTCLQAGS
YVLRFYNTYS LVHSKRISYT VEVLLPDQTF MEKMEKF
