ID   BEL1_SFVCP              Reviewed;         300 AA.
AC   Q87042;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   02-JUN-2021, entry version 60.
DE   RecName: Full=Protein Bel-1;
DE   AltName: Full=Transactivator of spumavirus;
DE            Short=Tas;
DE   AltName: Full=Transcriptional transactivator;
GN   Name=bel1; Synonyms=Taf, tas;
OS   Simian foamy virus (isolate chimpanzee) (SFVcpz).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Spumaretrovirinae; Spumavirus.
OX   NCBI_TaxID=298339;
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8184531; DOI=10.1006/viro.1994.1285;
RA   Herchenroder O., Renne R., Loncar D., Cobb E.K., Murthy K.K., Schneider J.,
RA   Mergia A., Luciw P.A.;
RT   "Isolation, cloning, and sequencing of simian foamy viruses from
RT   chimpanzees (SFVcpz): high homology to human foamy virus (HFV).";
RL   Virology 201:187-199(1994).
CC   -!- FUNCTION: Transcriptional transactivator that activates the viral
CC       internal promoter (IP), thereby enhancing its own expression. This
CC       transactivation is repressed by nuclear factor I. Also transactivates
CC       the long terminal repeat (LTR) promoter, thereby inducing structural
CC       gene expression, initiating the late phase of infection. It is
CC       therefore a key regulator of viral gene expression. It directly binds
CC       to and activates DNA target sites of viral promoters and those of
CC       distinct cellular genes. Required for viral replication (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer or homomultimer. Forms complexes with the host
CC       nuclear factors NFIA, NFIB, NFIC or NFIX (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC         Comment=The first 88 residues are shared by isoform Bel-1 and isoform
CC         Bet.;
CC       Name=Bel-1; Synonyms=Bel1;
CC         IsoId=Q87042-1; Sequence=Displayed;
CC       Name=Bet;
CC         IsoId=Q87043-1; Sequence=External;
CC       Name=Bel-2; Synonyms=Bel2;
CC         IsoId=Q87043-2; Sequence=External;
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DR   EMBL; U04327; AAA19980.1; -; Genomic_DNA.
DR   RefSeq; NP_056805.1; NC_001364.1.
DR   GeneID; 1489967; -.
DR   KEGG; vg:1489967; -.
DR   Proteomes; UP000001063; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR004956; Foamy_BEL.
DR   Pfam; PF03274; Foamy_BEL; 2.
PE   3: Inferred from homology;
KW   Activator; Alternative splicing; DNA-binding; Host nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..300
FT                   /note="Protein Bel-1"
FT                   /id="PRO_0000378586"
FT   DNA_BIND        89..200
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          26..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          185..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          224..300
FT                   /note="Transactivation domain"
FT                   /evidence="ECO:0000255"
FT   MOTIF           214..223
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        192..213
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   300 AA;  33834 MW;  CF6616096BA9A440 CRC64;
     MDSYQEEEPV ASTSGLQDLQ TLSELVGPEN AGEGDLVIAE EPEENPRRPR RYTKRDVKCV
     SYHAYKELED KHPHHIKLQD WIPKPEEMSK SICKRLILCG LYSGEKAREI LKKPFTVSWE
     QSETNPDCFI VSYTCIFCDA VIHDPMPVVW DSEVEIWVKY KPLRGIVGSA VFIMEKHQKN
     CSLVKPSTSC PEGPKPRRRH DPVLRCDMFE KHHKPRPKRS RKRSIDHESC ASSGDTVANE
     SGPLCTNTFW TPGPVLQGLL GESSNLPDLE VHMSGGPFWK EVYGDSILGP PSGSGEHSVL