S15A5_HUMAN
ID S15A5_HUMAN Reviewed; 579 AA.
AC A6NIM6;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Solute carrier family 15 member 5;
GN Name=SLC15A5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
CC -!- FUNCTION: Proton oligopeptide cotransporter. {ECO:0000305}.
CC -!- INTERACTION:
CC A6NIM6; Q14160: SCRIB; NbExp=2; IntAct=EBI-11792220, EBI-357345;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC073574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001164269.1; NM_001170798.1.
DR AlphaFoldDB; A6NIM6; -.
DR SMR; A6NIM6; -.
DR IntAct; A6NIM6; 2.
DR MINT; A6NIM6; -.
DR STRING; 9606.ENSP00000340402; -.
DR TCDB; 2.A.17.3.10; the proton-dependent oligopeptide transporter (pot/ptr) family.
DR PhosphoSitePlus; A6NIM6; -.
DR BioMuta; SLC15A5; -.
DR PaxDb; A6NIM6; -.
DR PeptideAtlas; A6NIM6; -.
DR PRIDE; A6NIM6; -.
DR Antibodypedia; 63873; 11 antibodies from 6 providers.
DR DNASU; 729025; -.
DR Ensembl; ENST00000344941.3; ENSP00000340402.3; ENSG00000188991.3.
DR GeneID; 729025; -.
DR KEGG; hsa:729025; -.
DR MANE-Select; ENST00000344941.3; ENSP00000340402.3; NM_001170798.1; NP_001164269.1.
DR UCSC; uc021qvs.1; human.
DR CTD; 729025; -.
DR GeneCards; SLC15A5; -.
DR HGNC; HGNC:33455; SLC15A5.
DR HPA; ENSG00000188991; Not detected.
DR neXtProt; NX_A6NIM6; -.
DR OpenTargets; ENSG00000188991; -.
DR PharmGKB; PA164725785; -.
DR VEuPathDB; HostDB:ENSG00000188991; -.
DR eggNOG; KOG1237; Eukaryota.
DR GeneTree; ENSGT00940000158916; -.
DR HOGENOM; CLU_009313_6_2_1; -.
DR InParanoid; A6NIM6; -.
DR OMA; TVNLCFI; -.
DR OrthoDB; 365203at2759; -.
DR PhylomeDB; A6NIM6; -.
DR TreeFam; TF332925; -.
DR PathwayCommons; A6NIM6; -.
DR SignaLink; A6NIM6; -.
DR BioGRID-ORCS; 729025; 5 hits in 248 CRISPR screens.
DR GenomeRNAi; 729025; -.
DR Pharos; A6NIM6; Tdark.
DR PRO; PR:A6NIM6; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; A6NIM6; protein.
DR Bgee; ENSG00000188991; Expressed in substantia nigra and 18 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0015833; P:peptide transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR000109; POT_fam.
DR PANTHER; PTHR11654; PTHR11654; 1.
DR Pfam; PF00854; PTR2; 1.
DR SUPFAM; SSF103473; SSF103473; 2.
PE 1: Evidence at protein level;
KW Membrane; Peptide transport; Protein transport; Reference proteome;
KW Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..579
FT /note="Solute carrier family 15 member 5"
FT /id="PRO_0000332233"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 422..442
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 509..529
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 141
FT /note="H -> Q (in dbSNP:rs1799516)"
FT /id="VAR_042979"
FT VARIANT 271
FT /note="P -> L (in dbSNP:rs1527014)"
FT /id="VAR_042980"
FT VARIANT 494
FT /note="D -> E (in dbSNP:rs1671511)"
FT /id="VAR_042981"
FT VARIANT 508
FT /note="E -> K (in dbSNP:rs3946358)"
FT /id="VAR_042982"
SQ SEQUENCE 579 AA; 65263 MW; 836D5266978C9977 CRC64;
MSVTGFTITD EKVHLYHSIE KEKTVRHIGD LCSSHSVKKI QVGICLLLVE LCERFTFFEV
VCNMIPFCTI KLGYHNCQAA ILNLCFIGTS ILTPVFVRWL TDVYLGRNKL VYICLFLHFL
GTALLSVVAF PLEDFYLGTY HAVNNIPKTE QHRLFYVALL TICLGIGGVR AIVCPLGAFG
LQEYGSQKTM SFFNWFYWLM NLNATIVFLG ISYIQHSQAW ALVLLIPFMS MLMAVITLHM
IYYNLIYQSE KRCSLLTGVG VLVSALKTCH PQYCHLGRDV TSQLDHAKEK NGGCYSELHV
EDTTFFLTLL PLFIFQLLYR MCIMQIPSGY YLQTMNSNLN LDGFLLPIAV MNAISSLPLL
ILAPFLEYFS TCLFPSKRVG SFLSTCIIAG NLFAALSVMI AGFFEIHRKH FPAVEQPLSG
KVLTVSSMPC FYLILQYVLL GVAETLVNPA LSVISYRFVP SNVRGTSMNF LTLFNGFGCF
TGALLVKLVY LISDGNWFPN TLNKGNLESF FFFLASLTLL NVLGFCSVSQ RYCNLNHFNA
QNIRGSNLEE TLLLHEKSLK FYGSIQEFSS SIDLWETAL
