S15A5_MOUSE
ID S15A5_MOUSE Reviewed; 566 AA.
AC Q8CBB2; B2RUQ4;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Solute carrier family 15 member 5;
GN Name=Slc15a5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Bone;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J; TISSUE=Bone;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Proton oligopeptide cotransporter. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CBB2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CBB2-2; Sequence=VSP_033358;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
CC {ECO:0000305}.
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DR EMBL; AK036413; BAC29419.1; -; mRNA.
DR EMBL; AC121849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC132431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC141332; AAI41333.1; -; mRNA.
DR EMBL; BC141334; AAI41335.1; -; mRNA.
DR RefSeq; NP_808455.2; NM_177787.4. [Q8CBB2-1]
DR AlphaFoldDB; Q8CBB2; -.
DR SMR; Q8CBB2; -.
DR STRING; 10090.ENSMUSP00000129239; -.
DR PhosphoSitePlus; Q8CBB2; -.
DR PaxDb; Q8CBB2; -.
DR PRIDE; Q8CBB2; -.
DR Antibodypedia; 63873; 11 antibodies from 6 providers.
DR DNASU; 277898; -.
DR Ensembl; ENSMUST00000171804; ENSMUSP00000129239; ENSMUSG00000044378. [Q8CBB2-1]
DR GeneID; 277898; -.
DR KEGG; mmu:277898; -.
DR UCSC; uc009eni.2; mouse. [Q8CBB2-1]
DR UCSC; uc009enj.1; mouse. [Q8CBB2-2]
DR CTD; 729025; -.
DR MGI; MGI:3607714; Slc15a5.
DR VEuPathDB; HostDB:ENSMUSG00000044378; -.
DR eggNOG; KOG1237; Eukaryota.
DR GeneTree; ENSGT00940000158916; -.
DR HOGENOM; CLU_009313_6_2_1; -.
DR InParanoid; Q8CBB2; -.
DR OMA; TVNLCFI; -.
DR OrthoDB; 365203at2759; -.
DR PhylomeDB; Q8CBB2; -.
DR TreeFam; TF332925; -.
DR BioGRID-ORCS; 277898; 1 hit in 65 CRISPR screens.
DR ChiTaRS; Slc15a5; mouse.
DR PRO; PR:Q8CBB2; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8CBB2; protein.
DR Bgee; ENSMUSG00000044378; Expressed in animal zygote and 23 other tissues.
DR ExpressionAtlas; Q8CBB2; baseline and differential.
DR Genevisible; Q8CBB2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0015833; P:peptide transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR000109; POT_fam.
DR PANTHER; PTHR11654; PTHR11654; 1.
DR Pfam; PF00854; PTR2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Peptide transport; Protein transport;
KW Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..566
FT /note="Solute carrier family 15 member 5"
FT /id="PRO_0000332234"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 493..513
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..119
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_033358"
SQ SEQUENCE 566 AA; 62622 MW; 62CFD961177B0613 CRC64;
MPITDFIIND EKTPLVLHGG PEQWKTVGPY GCFRVGICLL LVELCERFTF FEVVCNMIPF
CTGRLGSYNH QAAMLNLGFI GTSVLTPVFM GWLADEYFGR NKLMYIALSL HFLGTALLSM
LAFPAENFYR GAYPVFNNTS VEEQAGLFHV ALLTLCLGTG GIRAVVCPPD MCGSQERESK
KPMPFCNWAS WSANLNAAVV FLGISSIQPL GSGALGILLP SLSVFTALVT LYLKHCDLIY
RPENRCSLLT IARAFVRALK TRCLPYCHFG RDGSSWLDHA MEKQGGHHSE LQEEDTRNIS
ALLPLFSFQI LYRTCLLQIP SGYYLQTMNS NRNWGGFSLP IALMNAISLL PLLILPPFMD
YFSNCLLPSK RDGPFLSACM IAGNICAASS VAMAGFLEIY RKLAREQSPS GKLFSVSSMA
CVCLVPQYVL LGVSEVLVNP AVSMVTHRVI PGASMAFLTL SHGSACFAGA MLIKLLYLIS
EGNWFPNTLD KGNLENFFFV LASLMLLNIL GLWRASWRYC NLNHFNAQRI RGNRCEETLL
LTEKSLKFYG STQGASSSID LWETAL
