ID   S16C6_BOVIN             Reviewed;         316 AA.
AC   A5PJJ7;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Short-chain dehydrogenase/reductase family 16C member 6;
DE            EC=1.1.1.-;
GN   Name=SDR16C6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; BC142138; AAI42139.1; -; mRNA.
DR   RefSeq; NP_001093177.1; NM_001099707.1.
DR   AlphaFoldDB; A5PJJ7; -.
DR   SMR; A5PJJ7; -.
DR   STRING; 9913.ENSBTAP00000048107; -.
DR   PaxDb; A5PJJ7; -.
DR   GeneID; 525500; -.
DR   KEGG; bta:525500; -.
DR   CTD; 242286; -.
DR   eggNOG; KOG1201; Eukaryota.
DR   HOGENOM; CLU_010194_2_5_1; -.
DR   InParanoid; A5PJJ7; -.
DR   OrthoDB; 1373099at2759; -.
DR   TreeFam; TF312837; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005811; C:lipid droplet; IBA:GO_Central.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   NAD; NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..316
FT                   /note="Short-chain dehydrogenase/reductase family 16C
FT                   member 6"
FT                   /id="PRO_0000386456"
FT   ACT_SITE        186
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         40..64
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         173
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   316 AA;  35659 MW;  2C9C895AD9C35B17 CRC64;
     MNVLLDTSIF LGKFLYYFLE SLYYKIIPKK KKDVTGEIVL ITGAASGLGR LLAIKFASLG
     AILVLWDINE EGNMETCRII KEERDAKVFA YTCDCSNRQD VYRVADQVKK EVGNVTILIN
     NAGVVTGREF LKTPDHMVER SFLVNVMSHF WTYKAFLPAM LEANHGHLVC ISSFAGIVGI
     NELSDYCASK FAAYGFAESL HFELKLLQKS KINTTIVCPY FIKTGMFEGC STKYPLLLPM
     LTQEYAAQSI LNAILEEQLY LIMPRFSHVA LFLKQIISTN MMMTMAEYLG MDISLASFIE
     REKSGEVQTK TEGKQQ