ID   S16C6_MOUSE             Reviewed;         316 AA.
AC   Q05A13;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Short-chain dehydrogenase/reductase family 16C member 6;
DE            EC=1.1.1.-;
GN   Name=Sdr16c6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AL807387; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX004841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466538; EDL05701.1; -; Genomic_DNA.
DR   EMBL; BC125450; AAI25451.1; -; mRNA.
DR   EMBL; BC125452; AAI25453.1; -; mRNA.
DR   CCDS; CCDS38688.1; -.
DR   RefSeq; NP_001074179.1; NM_001080710.2.
DR   AlphaFoldDB; Q05A13; -.
DR   SMR; Q05A13; -.
DR   STRING; 10090.ENSMUSP00000104020; -.
DR   PaxDb; Q05A13; -.
DR   PRIDE; Q05A13; -.
DR   ProteomicsDB; 255443; -.
DR   Ensembl; ENSMUST00000095151; ENSMUSP00000092773; ENSMUSG00000071019.
DR   Ensembl; ENSMUST00000108383; ENSMUSP00000104020; ENSMUSG00000071019.
DR   GeneID; 242286; -.
DR   KEGG; mmu:242286; -.
DR   UCSC; uc008rwy.1; mouse.
DR   CTD; 242286; -.
DR   MGI; MGI:2685269; Sdr16c6.
DR   VEuPathDB; HostDB:ENSMUSG00000071019; -.
DR   eggNOG; KOG1201; Eukaryota.
DR   GeneTree; ENSGT00940000163618; -.
DR   HOGENOM; CLU_010194_2_5_1; -.
DR   InParanoid; Q05A13; -.
DR   OMA; MIKANHG; -.
DR   OrthoDB; 1373099at2759; -.
DR   PhylomeDB; Q05A13; -.
DR   TreeFam; TF312837; -.
DR   BRENDA; 1.1.1.105; 3474.
DR   BioGRID-ORCS; 242286; 4 hits in 71 CRISPR screens.
DR   PRO; PR:Q05A13; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q05A13; protein.
DR   Bgee; ENSMUSG00000071019; Expressed in tail skin and 27 other tissues.
DR   Genevisible; Q05A13; MM.
DR   GO; GO:0005811; C:lipid droplet; IBA:GO_Central.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   NAD; NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..316
FT                   /note="Short-chain dehydrogenase/reductase family 16C
FT                   member 6"
FT                   /id="PRO_0000386458"
FT   ACT_SITE        186
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         40..64
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         173
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   316 AA;  35158 MW;  CEDB810B99CD39C9 CRC64;
     MNSVADTAIF FGKFLYYFLE SLVFKVIPKR KKDVSGEIVL ITGAGSGLGR LLAIHFASHG
     ATLVLWDINQ EGNMETCRLV KQKGDVKVFA YKCDCSSRIE VYRVADQVKE EVGDVTILIN
     NAGVVTGKSF LNTPDHLVEK SFLVNAISHF WTCKAFLPAM VKANHGHLVC ISSIAGLVGI
     NGLSDYSSSK FAAFGFAESL FLELTMIMKT KVKSTIVCPY FIKTGMFEGC TTKYPLLLPL
     LEQEYVAQKI FNAILEEQVY LIIPKFAYVA LFLKQIISPK MMIALGEYLG VDTCMTSFTG
     RVKAEELQME TKRKEQ