S17A4_HUMAN
ID S17A4_HUMAN Reviewed; 497 AA.
AC Q9Y2C5; B4DDV9; E7EPE8; E7EU17; Q32MB7; Q32MB8;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Probable small intestine urate exporter;
DE AltName: Full=Solute carrier family 17 member 4;
GN Name=SLC17A4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Small intestine;
RX PubMed=10319585; DOI=10.1007/s100380050140;
RA Shibui A., Tsunoda T., Seki N., Suzuki Y., Sugane K., Sugano S.;
RT "Isolation and chromosomal mapping of a novel human gene showing homology
RT to Na+/PO4 cotransporter.";
RL J. Hum. Genet. 44:190-192(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Urinary bladder;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), AND VARIANT
RP THR-372.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=22460716; DOI=10.1152/ajpcell.00015.2012;
RA Togawa N., Miyaji T., Izawa S., Omote H., Moriyama Y.;
RT "A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal
RT organic anion exporter.";
RL Am. J. Physiol. 302:C1652-C1660(2012).
CC -!- FUNCTION: Acts as a membrane potential-dependent organic anion
CC transporter, the transport requires a low concentration of chloride
CC ions. May be involved in urate extrusion from the intestinal duct. May
CC recognize hydrophilic anionic drugs such as aspirin, salicylate, and
CC ibuprofen as substrates. Able to actively transport inorganic phosphate
CC into cells via Na(+) cotransport (in vitro).
CC {ECO:0000269|PubMed:22460716}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000269|PubMed:22460716}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:22460716}. Cell membrane
CC {ECO:0000269|PubMed:22460716}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:22460716}. Note=Apical in the intestinal brush
CC border.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q9Y2C5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y2C5-2; Sequence=VSP_031178;
CC Name=3;
CC IsoId=Q9Y2C5-3; Sequence=VSP_054938;
CC Name=4;
CC IsoId=Q9Y2C5-4; Sequence=VSP_031178, VSP_054939, VSP_054940,
CC VSP_054941;
CC -!- TISSUE SPECIFICITY: Abundantly expressed in pancreas, liver, colon and
CC small intestine, less in kidney. Not detected in the adrenal glands,
CC brain, placenta, heart, testis, skeletal muscle, and lungs.
CC {ECO:0000269|PubMed:10319585, ECO:0000269|PubMed:22460716}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion
CC cotransporter family. {ECO:0000305}.
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DR EMBL; AB020527; BAA76663.1; -; mRNA.
DR EMBL; AK293354; BAG56870.1; -; mRNA.
DR EMBL; AL391194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471087; EAW55492.1; -; Genomic_DNA.
DR EMBL; BC109207; AAI09208.1; -; mRNA.
DR EMBL; BC109208; AAI09209.1; -; mRNA.
DR CCDS; CCDS4564.1; -. [Q9Y2C5-1]
DR CCDS; CCDS75411.1; -. [Q9Y2C5-2]
DR RefSeq; NP_001273050.1; NM_001286121.1. [Q9Y2C5-2]
DR RefSeq; NP_005486.1; NM_005495.2. [Q9Y2C5-1]
DR RefSeq; XP_011512513.1; XM_011514211.1. [Q9Y2C5-2]
DR RefSeq; XP_011512521.1; XM_011514219.2. [Q9Y2C5-3]
DR AlphaFoldDB; Q9Y2C5; -.
DR SMR; Q9Y2C5; -.
DR BioGRID; 115361; 1.
DR STRING; 9606.ENSP00000367137; -.
DR TCDB; 2.A.1.14.24; the major facilitator superfamily (mfs).
DR GlyGen; Q9Y2C5; 5 sites.
DR iPTMnet; Q9Y2C5; -.
DR PhosphoSitePlus; Q9Y2C5; -.
DR BioMuta; SLC17A4; -.
DR DMDM; 74753468; -.
DR MassIVE; Q9Y2C5; -.
DR PaxDb; Q9Y2C5; -.
DR PeptideAtlas; Q9Y2C5; -.
DR PRIDE; Q9Y2C5; -.
DR Antibodypedia; 10729; 68 antibodies from 19 providers.
DR DNASU; 10050; -.
DR Ensembl; ENST00000377905.9; ENSP00000367137.4; ENSG00000146039.11. [Q9Y2C5-1]
DR Ensembl; ENST00000397076.2; ENSP00000380266.2; ENSG00000146039.11. [Q9Y2C5-4]
DR Ensembl; ENST00000439485.6; ENSP00000391345.3; ENSG00000146039.11. [Q9Y2C5-2]
DR GeneID; 10050; -.
DR KEGG; hsa:10050; -.
DR MANE-Select; ENST00000377905.9; ENSP00000367137.4; NM_005495.3; NP_005486.1.
DR UCSC; uc003nfe.4; human. [Q9Y2C5-1]
DR CTD; 10050; -.
DR DisGeNET; 10050; -.
DR GeneCards; SLC17A4; -.
DR HGNC; HGNC:10932; SLC17A4.
DR HPA; ENSG00000146039; Group enriched (gallbladder, intestine, liver, pancreas).
DR MIM; 604216; gene.
DR neXtProt; NX_Q9Y2C5; -.
DR OpenTargets; ENSG00000146039; -.
DR PharmGKB; PA35823; -.
DR VEuPathDB; HostDB:ENSG00000146039; -.
DR eggNOG; KOG2532; Eukaryota.
DR GeneTree; ENSGT00940000160894; -.
DR HOGENOM; CLU_001265_5_0_1; -.
DR InParanoid; Q9Y2C5; -.
DR OMA; IGWPYIF; -.
DR OrthoDB; 577796at2759; -.
DR PhylomeDB; Q9Y2C5; -.
DR TreeFam; TF313535; -.
DR PathwayCommons; Q9Y2C5; -.
DR BioGRID-ORCS; 10050; 5 hits in 1061 CRISPR screens.
DR GenomeRNAi; 10050; -.
DR Pharos; Q9Y2C5; Tdark.
DR PRO; PR:Q9Y2C5; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9Y2C5; protein.
DR Bgee; ENSG00000146039; Expressed in mucosa of transverse colon and 44 other tissues.
DR ExpressionAtlas; Q9Y2C5; baseline and differential.
DR Genevisible; Q9Y2C5; HS.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; TAS:ProtInc.
DR GO; GO:0015136; F:sialic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005436; F:sodium:phosphate symporter activity; TAS:ProtInc.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006820; P:anion transport; IBA:GO_Central.
DR GO; GO:0006796; P:phosphate-containing compound metabolic process; TAS:ProtInc.
DR GO; GO:0015739; P:sialic acid transport; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; TAS:ProtInc.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..497
FT /note="Probable small intestine urate exporter"
FT /id="PRO_0000318166"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 90
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..54
FT /note="Missing (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031178"
FT VAR_SEQ 100..329
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054938"
FT VAR_SEQ 100..275
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_054939"
FT VAR_SEQ 373
FT /note="I -> IGKGETGHRGERGKLRAAFSLLCVCPPTP (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_054940"
FT VAR_SEQ 424..497
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_054941"
FT VARIANT 372
FT /note="A -> T (in dbSNP:rs11754288)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_038709"
FT CONFLICT 14
FT /note="I -> T (in Ref. 2; BAG56870)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 497 AA; 54055 MW; 5A5616AA52D4990D CRC64;
MSTGPDVKAT VGDISSDGNL NVAQEECSRK GFCSVRHGLA LILQLCNFSI YTQQMNLSIA
IPAMVNNTAP PSQPNASTER PSTDSQGYWN ETLKEFKAMA PAYDWSPEIQ GIILSSLNYG
SFLAPIPSGY VAGIFGAKYV VGAGLFISSF LTLFIPLAAN AGVALLIVLR IVQGIAQVMV
LTGQYSIWVK WAPPLERSQL TTIAGSGSML GSFIVLLAGG LLCQTIGWPY VFYIFGGIGC
ACCPLWFPLI YDDPVNHPFI SAGEKRYIVC SLAQQDCSPG WSLPIRAMIK SLPLWAILVS
YFCEYWLFYT IMAYTPTYIS SVLQANLRDS GILSALPFVV GCICIILGGL LADFLLSRKI
LRLITIRKLF TAIGVLFPSV ILVSLPWVRS SHSMTMTFLV LSSAISSFCE SGALVNFLDI
APRYTGFLKG LLQVFAHIAG AISPTAAGFF ISQDSEFGWR NVFLLSAAVN ISGLVFYLIF
GRADVQDWAK EQTFTHL
