S17A4_MOUSE
ID S17A4_MOUSE Reviewed; 492 AA.
AC Q5NCM1; B9EJP0;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Probable small intestine urate exporter;
DE AltName: Full=Solute carrier family 17 member 4;
GN Name=Slc17a4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Acts as a membrane potential-dependent organic anion
CC transporter, the transport requires a low concentration of chloride
CC ions. May be involved in urate extrusion from the intestinal duct. May
CC recognize hydrophilic anionic drugs such as aspirin, salicylate, and
CC ibuprofen as substrates. Able to actively transport inorganic phosphate
CC into cells via Na(+) cotransport (in vitro) (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass
CC membrane protein. Note=Apical in the intestinal brush border.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion
CC cotransporter family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAI35970.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL606464; CAI35970.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC147415; AAI47416.1; -; mRNA.
DR EMBL; BC147416; AAI47417.1; -; mRNA.
DR CCDS; CCDS49221.1; -.
DR RefSeq; NP_795990.2; NM_177016.3.
DR AlphaFoldDB; Q5NCM1; -.
DR SMR; Q5NCM1; -.
DR STRING; 10090.ENSMUSP00000021769; -.
DR GlyGen; Q5NCM1; 6 sites.
DR iPTMnet; Q5NCM1; -.
DR PhosphoSitePlus; Q5NCM1; -.
DR PaxDb; Q5NCM1; -.
DR PRIDE; Q5NCM1; -.
DR ProteomicsDB; 260973; -.
DR Antibodypedia; 10729; 68 antibodies from 19 providers.
DR DNASU; 319848; -.
DR Ensembl; ENSMUST00000021769; ENSMUSP00000021769; ENSMUSG00000021336.
DR GeneID; 319848; -.
DR KEGG; mmu:319848; -.
DR UCSC; uc007pvh.1; mouse.
DR CTD; 10050; -.
DR MGI; MGI:2442850; Slc17a4.
DR VEuPathDB; HostDB:ENSMUSG00000021336; -.
DR eggNOG; KOG2532; Eukaryota.
DR GeneTree; ENSGT00940000160894; -.
DR HOGENOM; CLU_001265_5_0_1; -.
DR InParanoid; Q5NCM1; -.
DR OMA; IGWPYIF; -.
DR OrthoDB; 577796at2759; -.
DR PhylomeDB; Q5NCM1; -.
DR TreeFam; TF313535; -.
DR BioGRID-ORCS; 319848; 3 hits in 73 CRISPR screens.
DR PRO; PR:Q5NCM1; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q5NCM1; protein.
DR Bgee; ENSMUSG00000021336; Expressed in jejunum and 27 other tissues.
DR ExpressionAtlas; Q5NCM1; baseline and differential.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0015136; F:sialic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006820; P:anion transport; IBA:GO_Central.
DR GO; GO:0015739; P:sialic acid transport; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Ion transport; Membrane; Reference proteome;
KW Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..492
FT /note="Probable small intestine urate exporter"
FT /id="PRO_0000318167"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 426..446
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 53
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 72
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 492 AA; 53668 MW; 78C0F8C096546CC2 CRC64;
MSTGADLKAR EGDIPSDNMT QEQSFKKGFC SLRHGLAFIL HLCNFSIYTQ QMNLSFAITA
MVNTTVASSQ LNASTERPPT NSQDVWNETL QESKAPVYDW TPEIQGILLS SLSYGSFIAP
IPTGYVAGVF GAKYVVGLGL LISSVLTLFI PLAADAGVAL LIVLRVIQGM AQVMVLTGQY
SLWAKWAPPQ ERSQLITIAA SGSMLGTFLV LIAGGLICQA LGWPYIFYIF GGIGCACCLL
WFPLVYDDPQ NHPFISTGER RYITCSLAQE DCSLGWSLPI KAMVKSLPLW AIVVSYFCEY
WLLSTVMAYT PTYISSVLQA NLRDSGILSA LPFMFGCVCI ILGGLLADFL LSRKILRLVT
IRKLFTAVGV LASSGILLPL PWVRSSRSTT MAFLVLSSVF ASLCDSGALI NFLDIAPRYA
GFLKGLLQVF SYLAGGIAPT VAGFFISQDS EFGWRNVFFL AAAIDVVGLL FYLIFSRAEV
QDWAKEPTFT HL
