S17A9_MOUSE
ID S17A9_MOUSE Reviewed; 447 AA.
AC Q8VCL5; A2AJ51;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Solute carrier family 17 member 9;
GN Name=Slc17a9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=18375752; DOI=10.1073/pnas.0800141105;
RA Sawada K., Echigo N., Juge N., Miyaji T., Otsuka M., Omote H., Yamamoto A.,
RA Moriyama Y.;
RT "Identification of a vesicular nucleotide transporter.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:5683-5686(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Involved in vesicular storage and exocytosis of ATP. May
CC accumulate ATP and other nucleotides in secretory vesicles such as
CC adrenal chromaffin granules and synaptic vesicles (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: In brain, specifically expressed in the medulla and
CC is associated with chromaffin granules (at protein level).
CC Predominantly expressed in adrenal gland, brain and thyroid.
CC {ECO:0000269|PubMed:18375752}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion
CC cotransporter family. {ECO:0000305}.
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DR EMBL; AL732560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS38378.1; -.
DR RefSeq; NP_898984.3; NM_183161.3.
DR AlphaFoldDB; Q8VCL5; -.
DR SMR; Q8VCL5; -.
DR IntAct; Q8VCL5; 1.
DR STRING; 10090.ENSMUSP00000091771; -.
DR PhosphoSitePlus; Q8VCL5; -.
DR MaxQB; Q8VCL5; -.
DR PaxDb; Q8VCL5; -.
DR PRIDE; Q8VCL5; -.
DR ProteomicsDB; 255447; -.
DR Antibodypedia; 66400; 22 antibodies from 9 providers.
DR DNASU; 228993; -.
DR Ensembl; ENSMUST00000094218; ENSMUSP00000091771; ENSMUSG00000023393.
DR GeneID; 228993; -.
DR KEGG; mmu:228993; -.
DR UCSC; uc008oka.1; mouse.
DR CTD; 63910; -.
DR MGI; MGI:1919107; Slc17a9.
DR VEuPathDB; HostDB:ENSMUSG00000023393; -.
DR eggNOG; KOG2532; Eukaryota.
DR GeneTree; ENSGT00940000158186; -.
DR HOGENOM; CLU_001265_5_11_1; -.
DR InParanoid; Q8VCL5; -.
DR OMA; CINVLTY; -.
DR OrthoDB; 840295at2759; -.
DR PhylomeDB; Q8VCL5; -.
DR TreeFam; TF313341; -.
DR BioGRID-ORCS; 228993; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Slc17a9; mouse.
DR PRO; PR:Q8VCL5; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8VCL5; protein.
DR Bgee; ENSMUSG00000023393; Expressed in granulocyte and 107 other tissues.
DR Genevisible; Q8VCL5; MM.
DR GO; GO:0042584; C:chromaffin granule membrane; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030141; C:secretory granule; IDA:MGI.
DR GO; GO:0015217; F:ADP transmembrane transporter activity; ISO:MGI.
DR GO; GO:0005347; F:ATP transmembrane transporter activity; ISO:MGI.
DR GO; GO:0001409; F:guanine nucleotide transmembrane transporter activity; ISO:MGI.
DR GO; GO:0015866; P:ADP transport; ISO:MGI.
DR GO; GO:1904669; P:ATP export; ISO:MGI.
DR GO; GO:0015867; P:ATP transport; ISO:MGI.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:1903790; P:guanine nucleotide transmembrane transport; ISO:MGI.
DR CDD; cd17380; MFS_SLC17A9_like; 1.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR044777; SLC17A9-like.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 1: Evidence at protein level;
KW Exocytosis; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..447
FT /note="Solute carrier family 17 member 9"
FT /id="PRO_0000084850"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 48479 MW; 3DC7857519BA8525 CRC64;
MPSQRSSLMQ PIPEETRKTP SAAAEDTRWS RPECQAWTGI LLLGTCLLYC ARVTMPVCTV
AMSQDFGWNK KEAGIVLSSF FWGYCLTQVV GGHLGDRIGG EKVILLSASA WGFITVTTPL
LAHLGSGHLA FLTFSRILTG LLQGVYFPAL TSLLSQKVQE SERAFTYSTV GAGSQVGTLV
TGGVGSVLLD QCGWQSVFYF SGGLTLLWAY YVYRYLLNEK DLVLALGFLA QGLPVTKPSK
VPWRQLFRKA SVWAAICSQL CSACSFFILL SWLPTFFKET FPNSKGWVFN VVPWMLAIPA
SLFSGFISDR LISQGYRVIT VRKFMQVMGL GLSSIFALCL GHTTSFLKAM IFASASIGFQ
TFNHSGISVN IQDLAPSCAG FLFGVANTAG ALAGVVGVCL SGYLIETTGS WTCVFHLVAI
ISNLGLGTFL VFGKAQRVDL VPTHEDL
