S17B1_XENTR
ID S17B1_XENTR Reviewed; 376 AA.
AC Q8AWH2;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Transcription factor Sox-17-beta.1 {ECO:0000250|UniProtKB:O42601};
DE AltName: Full=SRY (sex determining region Y)-box 17-beta.1;
DE Short=tSox17beta {ECO:0000303|PubMed:12508233};
GN Name=sox17b.1; ORFNames=TNeu127g05.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAN76330.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Gastrula {ECO:0000312|EMBL:AAN76330.1};
RX PubMed=12508233; DOI=10.1002/dvdy.10201;
RA D'Souza A., Lee M., Taverner N., Mason J., Carruthers S., Smith J.C.,
RA Amaya E., Papalopulu N., Zorn A.M.;
RT "Molecular components of the endoderm specification pathway in Xenopus
RT tropicalis.";
RL Dev. Dyn. 226:118-127(2003).
RN [2] {ECO:0000312|EMBL:CAJ82411.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula {ECO:0000312|EMBL:CAJ82411.1};
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription activator. Doesn't appear to bind to the
CC consensus 5'-AACAAT-3' DNA binding site, but binds 5'-ATTGTT-3'. All of
CC the sox17 proteins are required for embryonic endoderm development and
CC gastrulation movements, and show some redundancy in function. In
CC addition, the sox17 proteins have distinct but overlapping roles in
CC later gut development. Acts downstream of vegt-signaling in endoderm
CC differentiation to induce a range of endodermal genes both directly
CC (including endodermin and dhh/chh) and indirectly. Also represses wnt-
CC responsive genes to inhibit wnt/beta-catenin-mediated signaling (By
CC similarity). {ECO:0000250|UniProtKB:O42601}.
CC -!- SUBUNIT: Interacts (via C-terminus) with ctnnb1/beta-catenin (via
CC Armadillo repeats); this interaction is required for inhibition of wnt-
CC signaling. {ECO:0000250|UniProtKB:O42601}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O42601,
CC ECO:0000255|PROSITE-ProRule:PRU00267}.
CC -!- TISSUE SPECIFICITY: Expressed throughout all the deep and superficial
CC endoderm during gastrulation. Expression then declines rapidly after
CC gastrulation, however a small patch of endoderm cells behind the cement
CC gland maintains expression even into tailbud stages.
CC {ECO:0000269|PubMed:12508233}.
CC -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC number of yeast and animal transcription factors.
CC {ECO:0000250|UniProtKB:Q9H6I2}.
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DR EMBL; AY157636; AAN76330.1; -; mRNA.
DR EMBL; CR848411; CAJ82411.1; -; mRNA.
DR RefSeq; NP_988849.1; NM_203518.1.
DR AlphaFoldDB; Q8AWH2; -.
DR SMR; Q8AWH2; -.
DR GeneID; 394440; -.
DR KEGG; xtr:394440; -.
DR CTD; 394440; -.
DR Xenbase; XB-GENE-484865; sox17b.1.
DR InParanoid; Q8AWH2; -.
DR OrthoDB; 1641977at2759; -.
DR Reactome; R-XTR-3769402; Deactivation of the beta-catenin transactivating complex.
DR Proteomes; UP000008143; Chromosome 6.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000026438; Expressed in gastrula and 22 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0001525; P:angiogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
DR GO; GO:0007507; P:heart development; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0001570; P:vasculogenesis; IBA:GO_Central.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR021934; Sox_C.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
DR PROSITE; PS51516; SOX_C; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Gastrulation; Nucleus;
KW Reference proteome; Transcription; Transcription regulation;
KW Wnt signaling pathway.
FT CHAIN 1..376
FT /note="Transcription factor Sox-17-beta.1"
FT /id="PRO_0000382473"
FT DOMAIN 259..376
FT /note="Sox C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00849"
FT DNA_BIND 58..126
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 327..331
FT /note="Required for transcriptional activity and
FT interaction with ctnnb1"
FT /evidence="ECO:0000250|UniProtKB:O42601"
FT MOTIF 326..334
FT /note="9aaTAD"
FT /evidence="ECO:0000250|UniProtKB:Q9H6I2"
SQ SEQUENCE 376 AA; 42787 MW; 00D4675657AC2329 CRC64;
MSSPDGGYAS DDQFHGNCSV PIMMGQYEWT DPLTMFQDAK TKKEAGSANS RGKAEARIRR
PMNAFMVWAK DERKRLAQQN PDLHNAELSK MLGKSWKSLT LASKRPFVEE AERLRVQHIQ
DYPDYKYRPR RKKQVKRMKR EEEGFLPSAD IPGPQVMGCN AMVGQNYKMQ YSGQNSQQSQ
ITPAGYFEDH NPVGYYYRGY NVPEYYMSQN SSVTCGPPAQ GEYQALSYNF NSSYIPYQQN
ASAPAMGKQM AVKENIIQES PEHGIMGCQV SPQMYNGQMY VPECAKTHPV AQTEQHSSLH
QSQQMVTQNY LPSQQDGHLE SDIDKTEFDQ YLMYEPKSDT ELIYTIDQDS GAYSTNLLPS
LISEANSVCY YDYCGV
