S17B2_XENTR
ID S17B2_XENTR Reviewed; 373 AA.
AC Q6GLH8;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Transcription factor Sox-17-beta.2 {ECO:0000250|UniProtKB:O42601};
DE AltName: Full=SRY (sex determining region Y)-box 17-beta.2;
GN Name=sox17b.2;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:AAT71998.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Qin S., Dors M., Johnson E., Bloom S., Hood L., Rowen L.;
RT "Sequence of Xenopus tropicalis development genes.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:AAT71998.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH74512.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription activator. Doesn't appear to bind to the
CC consensus 5'-AACAAT-3' DNA binding site, but binds 5'-ATTGTT-3'. All of
CC the sox17 proteins are required for embryonic endoderm development and
CC gastrulation movements, and show some redundancy in function. In
CC addition, the sox17 proteins have distinct but overlapping roles in
CC later gut development. Acts downstream of vegt-signaling in endoderm
CC differentiation to induce a range of endodermal genes both directly and
CC indirectly. Also represses wnt-responsive genes to inhibit wnt/beta-
CC catenin-mediated signaling (By similarity).
CC {ECO:0000250|UniProtKB:O42601}.
CC -!- SUBUNIT: Interacts (via C-terminus) with ctnnb1/beta-catenin (via
CC Armadillo repeats); this interaction is required for inhibition of wnt-
CC signaling. {ECO:0000250|UniProtKB:O42601}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O42601,
CC ECO:0000255|PROSITE-ProRule:PRU00267}.
CC -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC number of yeast and animal transcription factors.
CC {ECO:0000250|UniProtKB:Q9H6I2}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH74512.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAT71998.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC148408; AAT71998.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC074512; AAH74512.1; ALT_INIT; mRNA.
DR RefSeq; NP_001090837.1; NM_001097368.1.
DR AlphaFoldDB; Q6GLH8; -.
DR SMR; Q6GLH8; -.
DR STRING; 8364.ENSXETP00000060679; -.
DR PaxDb; Q6GLH8; -.
DR DNASU; 100038235; -.
DR Ensembl; ENSXETT00000017754; ENSXETP00000017754; ENSXETG00000026438.
DR GeneID; 100038235; -.
DR KEGG; xtr:100038235; -.
DR CTD; 100038235; -.
DR Xenbase; XB-GENE-495335; sox17b.2.
DR eggNOG; KOG0527; Eukaryota.
DR InParanoid; Q6GLH8; -.
DR OrthoDB; 1641977at2759; -.
DR Proteomes; UP000008143; Chromosome 6.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000026438; Expressed in gastrula and 22 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0001525; P:angiogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
DR GO; GO:0007507; P:heart development; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0001570; P:vasculogenesis; IBA:GO_Central.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR021934; Sox_C.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
DR PROSITE; PS51516; SOX_C; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Gastrulation; Nucleus;
KW Reference proteome; Transcription; Transcription regulation;
KW Wnt signaling pathway.
FT CHAIN 1..373
FT /note="Transcription factor Sox-17-beta.2"
FT /id="PRO_0000382474"
FT DOMAIN 256..373
FT /note="Sox C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00849"
FT DNA_BIND 58..126
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 324..328
FT /note="Required for transcriptional activity and
FT interaction with ctnnb1"
FT /evidence="ECO:0000250|UniProtKB:O42601"
FT MOTIF 323..331
FT /note="9aaTAD"
FT /evidence="ECO:0000250|UniProtKB:Q9H6I2"
SQ SEQUENCE 373 AA; 42433 MW; 8D0D3E47179855C9 CRC64;
MSSPDGGYAS DDQFHGNCSV PIMMGQYEWT DPLTMFQDAK TKKEAGSANS RGKAEARIRR
PMNAFMVWAK DERKRLAQQN PDLHNAELSK MLGKSWKSLT LASKRPFVKE AERLRVQHIQ
DYPDYKYRPR RKKQVKREEE GFLPSADIPG PQVMGCNAMV GQNYKMQYSG QNSQQSQITP
AGYFEDHNPV GFYYRGYNVP KYYMSQNSSG YCSPPTQGEY QALSYNFNSS YIPYQQNASA
PAMGKQMAVK ENIIQESPEH GIMGCQVSPQ MYNGQMYVPE CAKTHPVAQT EQHSSLHQSQ
QMVTQNYLPS QQDGHLESDI DKTEFDQYLM YEPKSDTELI YTIDQDSGAY STNLLPSLIS
EANSVCYYDY CGV
