ID   S17B3_XENLA             Reviewed;         373 AA.
AC   A5D8R3;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Transcription factor Sox-17-beta.3;
DE   AltName: Full=SRY (sex determining region Y)-box 17-beta.3;
GN   Name=sox17b.3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAI41781.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula {ECO:0000312|EMBL:AAI41781.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription activator. Doesn't appear to bind to the
CC       consensus 5'-AACAAT-3' DNA binding site, but binds 5'-ATTGTT-3'. All of
CC       the sox17 proteins are required for embryonic endoderm development and
CC       gastrulation movements, and show some redundancy in function. In
CC       addition, the sox17 proteins have distinct but overlapping roles in
CC       later gut development. Acts downstream of vegt-signaling in endoderm
CC       differentiation to induce a range of endodermal genes both directly and
CC       indirectly. Also represses wnt-responsive genes to inhibit wnt/beta-
CC       catenin-mediated signaling (By similarity).
CC       {ECO:0000250|UniProtKB:O42601}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with ctnnb1/beta-catenin (via
CC       Armadillo repeats); this interaction is required for inhibition of wnt-
CC       signaling. {ECO:0000250|UniProtKB:O42601}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O42601,
CC       ECO:0000255|PROSITE-ProRule:PRU00267}.
CC   -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC       number of yeast and animal transcription factors.
CC       {ECO:0000250|UniProtKB:Q9H6I2}.
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DR   EMBL; BC141780; AAI41781.1; -; mRNA.
DR   RefSeq; NP_001092185.1; NM_001098715.1.
DR   AlphaFoldDB; A5D8R3; -.
DR   SMR; A5D8R3; -.
DR   GeneID; 100049782; -.
DR   KEGG; xla:100049782; -.
DR   CTD; 100049782; -.
DR   Xenbase; XB-GENE-865510; sox17b.1.L.
DR   OMA; YCSPPTQ; -.
DR   OrthoDB; 1641977at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 100049782; Expressed in gastrula and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR021934; Sox_C.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
DR   PROSITE; PS51516; SOX_C; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Gastrulation; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation;
KW   Wnt signaling pathway.
FT   CHAIN           1..373
FT                   /note="Transcription factor Sox-17-beta.3"
FT                   /id="PRO_0000397924"
FT   DOMAIN          256..373
FT                   /note="Sox C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00849"
FT   DNA_BIND        58..126
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          33..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          324..328
FT                   /note="Required for transcriptional activity and
FT                   interaction with ctnnb1"
FT                   /evidence="ECO:0000250|UniProtKB:O42601"
FT   MOTIF           323..331
FT                   /note="9aaTAD"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6I2"
FT   COMPBIAS        36..55
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   373 AA;  43124 MW;  208F799D647AEFA3 CRC64;
     MSSPDCGYAS DDQIQRSCSL PMMMGQYQWT EPRTVFQEGK PKRDEVSANS RSKAEARIRR
     PMNAFMVWAK DERKRLAQQN PDLHNAELSK MLGKSWKSLN LATKRPFVEE AERLRVQHIQ
     DYPDYKYRPR RKKQVKRMKR EEECFFPSAN IPGPEAMVNN VMVGQKYKMQ YSVQNLQENQ
     LPTAGYFEGH SPMGYFYKDY DVPNYYTSQN SSGYCSPPTQ DEYQALSYGF GSSYMPYQQT
     TTTPVMAKQI SVTQNIPQES PEHGMMASPQ MYNGQMYLPE CAKTHPVAQT EQHSPSHQSQ
     QMVSQNYLQS QQDGHLETDI DKTEFDQYLM YEPKSDPELI YTIDQDSGPY STNLLPSLIS
     EANNVCYYDY CGV