ID   S17B3_XENTR             Reviewed;         376 AA.
AC   Q6F2F0;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 2.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Transcription factor Sox-17-beta.3;
DE   AltName: Full=SRY (sex determining region Y)-box 17-beta.3;
GN   Name=sox17b.3;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAT71997.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Qin S., Dors M., Johnson E., Bloom S., Hood L., Rowen L.;
RT   "Sequence of Xenopus tropicalis development genes.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription activator. Doesn't appear to bind to the
CC       consensus 5'-AACAAT-3' DNA binding site, but binds 5'-ATTGTT-3'. All of
CC       the sox17 proteins are required for embryonic endoderm development and
CC       gastrulation movements, and show some redundancy in function. In
CC       addition, the sox17 proteins have distinct but overlapping roles in
CC       later gut development. Acts downstream of vegt-signaling in endoderm
CC       differentiation to induce a range of endodermal genes both directly and
CC       indirectly. Also represses wnt-responsive genes to inhibit wnt/beta-
CC       catenin-mediated signaling (By similarity).
CC       {ECO:0000250|UniProtKB:O42601}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with ctnnb1/beta-catenin (via
CC       Armadillo repeats); this interaction is required for inhibition of wnt-
CC       signaling. {ECO:0000250|UniProtKB:O42601}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O42601,
CC       ECO:0000255|PROSITE-ProRule:PRU00267}.
CC   -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC       number of yeast and animal transcription factors.
CC       {ECO:0000250|UniProtKB:Q9H6I2}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAT71997.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AC148408; AAT71997.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q6F2F0; -.
DR   SMR; Q6F2F0; -.
DR   STRING; 8364.ENSXETP00000001541; -.
DR   PaxDb; Q6F2F0; -.
DR   Ensembl; ENSXETT00000001541; ENSXETP00000001541; ENSXETG00000026438.
DR   eggNOG; KOG0527; Eukaryota.
DR   InParanoid; Q6F2F0; -.
DR   Reactome; R-XTR-3769402; Deactivation of the beta-catenin transactivating complex.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000026438; Expressed in gastrula and 22 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0001525; P:angiogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
DR   GO; GO:0007507; P:heart development; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0001570; P:vasculogenesis; IBA:GO_Central.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR021934; Sox_C.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
DR   PROSITE; PS51516; SOX_C; 1.
PE   3: Inferred from homology;
KW   Activator; Developmental protein; DNA-binding; Gastrulation; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation;
KW   Wnt signaling pathway.
FT   CHAIN           1..376
FT                   /note="Transcription factor Sox-17-beta.3"
FT                   /id="PRO_0000382475"
FT   DOMAIN          259..376
FT                   /note="Sox C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00849"
FT   DNA_BIND        58..126
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          327..331
FT                   /note="Required for transcriptional activity and
FT                   interaction with ctnnb1"
FT                   /evidence="ECO:0000250|UniProtKB:O42601"
FT   MOTIF           326..334
FT                   /note="9aaTAD"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6I2"
SQ   SEQUENCE   376 AA;  42787 MW;  068D1865C92CF8CD CRC64;
     MSSPDGGYAS DDQIHGNCSV PIMMGQYEWT DPLTMFQDAK TKKEAGSANS RGKAEARIRR
     PMNAFMVWAK DERKRLAQQN PDLHNAELSK MLGKSWKSLT LASKRPFVEE AERLRVQHIQ
     DYPDYKYRPR RKKQVKRMKR EEEGFLPSAN LAGPQVMGCN AMVGQNYKMQ YSGQNSQQSQ
     ITPAGYFEDH NPVGYYYRGY NVSKYYMSQN SSGYCSPPAQ GEYQALSYNF NSSYMPYQQN
     ASTPAMGKQM AVKENIIQES PEHGIMGCQV SPQMYNGQMY VPECAKTHPV AQTEQHSSSH
     QSQQMVTQNY LPSQQDGHLE SDIDKTEFDQ YLMYEPKSDT ELIYTIDQDS GAYSTNLLPS
     LISEANSVCY YDYCGV