S18B1_MOUSE
ID S18B1_MOUSE Reviewed; 459 AA.
AC D3Z5L6;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 2.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=MFS-type transporter SLC18B1;
DE AltName: Full=Solute carrier family 18 member B1;
GN Name=Slc18b1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=19697161; DOI=10.1007/s12031-009-9222-7;
RA Jacobsson J.A., Stephansson O., Fredriksson R.;
RT "C6ORF192 forms a unique evolutionary branch among solute carriers (SLC16,
RT SLC17, and SLC18) and is abundantly expressed in several brain regions.";
RL J. Mol. Neurosci. 41:230-242(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Widely expressed, with highest expression in the
CC lung, pancreas and kidney. High expression in the CNS, particularly in
CC the hypothalamus, the thalamus and the cerebellum. In the forebrain,
CC abundantly expressed in the telencephalon, especially in the cerebral
CC cortex layers, except layer 1, as well as in the induseum griseum, the
CC piriform area, the taenia tecta, dorsal part and in the entorhinal
CC area, lateral part. Lower levels in the bed anterior olfactory nucleus,
CC posteroventral part and in layer two of the olfactory tubercle. In the
CC amygdala, high levels observed in the intercalated nucleus and the
CC medial nucleus. In the diencephalon, expressed in the nuclei in both
CC the hypothalamus and thalamus. Among the hypothalamic areas, strongest
CC expression in the arcuate nucleus and in the ventromedial nucleus, as
CC well as in the suprachiasmatic nucleus, anterior nucleus, especially in
CC its central part, and in the magnocellular division of the
CC paraventricular nucleus. In the thalamus, highest levels in the medial
CC habenula. Expression also observed in the paraventricular thalamic
CC nucleus, parataenial nucleus, central medial nucleus, intermediodorsal
CC nucleus and lateral dorsal nucleus. In the hindbrain, detected in the
CC cerebellum and in the pons. In the midbrain and the medulla, expression
CC levels were modest. In the midbrain, highest expression in the
CC periaqueductal gray and all subdivisions of the interpeduncular
CC nucleus, except for the caudal part. In the pons, the strongest
CC labeling was seen in the nucleus incertus and in the tegmental nucleus.
CC {ECO:0000269|PubMed:19697161}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; AC153973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC160147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; D3Z5L6; -.
DR SMR; D3Z5L6; -.
DR STRING; 10090.ENSMUSP00000112634; -.
DR MaxQB; D3Z5L6; -.
DR PaxDb; D3Z5L6; -.
DR PRIDE; D3Z5L6; -.
DR ProteomicsDB; 253353; -.
DR Antibodypedia; 32950; 72 antibodies from 16 providers.
DR Ensembl; ENSMUST00000179321; ENSMUSP00000137431; ENSMUSG00000037455.
DR MGI; MGI:1923556; Slc18b1.
DR VEuPathDB; HostDB:ENSMUSG00000037455; -.
DR eggNOG; KOG3764; Eukaryota.
DR GeneTree; ENSGT00940000156674; -.
DR InParanoid; D3Z5L6; -.
DR OMA; PTMSLFI; -.
DR PhylomeDB; D3Z5L6; -.
DR ChiTaRS; Slc18b1; mouse.
DR PRO; PR:D3Z5L6; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; D3Z5L6; protein.
DR Bgee; ENSMUSG00000037455; Expressed in epididymal fat pad and 207 other tissues.
DR ExpressionAtlas; D3Z5L6; baseline and differential.
DR Genevisible; D3Z5L6; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..459
FT /note="MFS-type transporter SLC18B1"
FT /id="PRO_0000394864"
FT TOPO_DOM 1..33
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..70
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..100
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..127
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..167
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..306
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..333
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 355..379
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 401..409
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 431..459
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q6NT16"
FT MOD_RES 21
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6NT16"
SQ SEQUENCE 459 AA; 49009 MW; B488C348F78D01A8 CRC64;
MDEAGSPAPA GTGGGDDPGG STRETSRRLS REQIFVLVSA ASMNLGCMMT YSILGPFFPK
EAEKKGASNT MIGMIFGCYA LFELLASLVF GKYLVHIGAK FMFIAGMFVS GGVTILFGVL
DQLPEGPIFI AMCFLVRIVD AIGFGAAITA SSSILAKAFP NNVATVMGSL EVFSGLGLVA
GPPLGGLLYQ SFGYEVPFIF LGCIVLLMIP LNLYILPSYA QESDPGKQSF WKLVTLPKMG
LLAFVIISLS SCFGFLDPTL SLFVMEKFSL STGYVGLVFL GLSLSYAISS PLFGLLSDKM
PTLRKWLLVF GNLITAGCYM LLGPVPLLHI KSQLWLLVLV LVVNGISAGM SIIPTFPEML
SCAYANGFED SISTLGLVSG LFGAMWSVGA FMGPILGGFL CEKIGFEWAA AMQGLWTLLS
GVSMALFYLW EDSTARRRSK AQNSLGTEEE RAALLPNDT
