S18L2_HUMAN
ID S18L2_HUMAN Reviewed; 77 AA.
AC Q9UHA2; B2R5L1;
DT 25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=SS18-like protein 2;
DE AltName: Full=SYT homolog 2;
GN Name=SS18L2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Dendritic cell;
RA Li Y., Wang G., Gu Y., Tu Y., Gu W., Wang Y., Han Z., Chen Z.;
RT "Novel genes expressed in human dendritic cells.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9UHA2; Q15006: EMC2; NbExp=3; IntAct=EBI-10962400, EBI-359031;
CC Q9UHA2; P63215: GNG3; NbExp=3; IntAct=EBI-10962400, EBI-1046668;
CC Q9UHA2; Q86Y78: LYPD6; NbExp=3; IntAct=EBI-10962400, EBI-14035066;
CC Q9UHA2; Q9P267-2: MBD5; NbExp=3; IntAct=EBI-10962400, EBI-17671489;
CC Q9UHA2; Q86X19: TMEM17; NbExp=3; IntAct=EBI-10962400, EBI-11343485;
CC Q9UHA2; Q9H869-2: YY1AP1; NbExp=4; IntAct=EBI-10962400, EBI-12150045;
CC -!- SIMILARITY: Belongs to the SS18 family. {ECO:0000305}.
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DR EMBL; AF201950; AAF17242.1; -; mRNA.
DR EMBL; AK312225; BAG35158.1; -; mRNA.
DR EMBL; CH471055; EAW64657.1; -; Genomic_DNA.
DR EMBL; BC017804; AAH17804.1; -; mRNA.
DR CCDS; CCDS2701.1; -.
DR RefSeq; NP_057389.1; NM_016305.3.
DR RefSeq; XP_016862037.1; XM_017006548.1.
DR RefSeq; XP_016862038.1; XM_017006549.1.
DR AlphaFoldDB; Q9UHA2; -.
DR SMR; Q9UHA2; -.
DR BioGRID; 119363; 73.
DR IntAct; Q9UHA2; 45.
DR STRING; 9606.ENSP00000401115; -.
DR iPTMnet; Q9UHA2; -.
DR PhosphoSitePlus; Q9UHA2; -.
DR BioMuta; SS18L2; -.
DR DMDM; 24418678; -.
DR EPD; Q9UHA2; -.
DR jPOST; Q9UHA2; -.
DR MassIVE; Q9UHA2; -.
DR MaxQB; Q9UHA2; -.
DR PaxDb; Q9UHA2; -.
DR PeptideAtlas; Q9UHA2; -.
DR PRIDE; Q9UHA2; -.
DR ProteomicsDB; 84290; -.
DR Antibodypedia; 29253; 26 antibodies from 14 providers.
DR DNASU; 51188; -.
DR Ensembl; ENST00000011691.6; ENSP00000011691.4; ENSG00000008324.12.
DR Ensembl; ENST00000447630.5; ENSP00000401115.1; ENSG00000008324.12.
DR GeneID; 51188; -.
DR KEGG; hsa:51188; -.
DR MANE-Select; ENST00000011691.6; ENSP00000011691.4; NM_001370300.1; NP_001357229.1.
DR UCSC; uc003clk.1; human.
DR CTD; 51188; -.
DR DisGeNET; 51188; -.
DR GeneCards; SS18L2; -.
DR HGNC; HGNC:15593; SS18L2.
DR HPA; ENSG00000008324; Low tissue specificity.
DR MIM; 606473; gene.
DR neXtProt; NX_Q9UHA2; -.
DR OpenTargets; ENSG00000008324; -.
DR PharmGKB; PA37990; -.
DR VEuPathDB; HostDB:ENSG00000008324; -.
DR eggNOG; KOG3227; Eukaryota.
DR GeneTree; ENSGT00940000160407; -.
DR HOGENOM; CLU_164146_1_0_1; -.
DR InParanoid; Q9UHA2; -.
DR OMA; GRAHECV; -.
DR OrthoDB; 1442230at2759; -.
DR PhylomeDB; Q9UHA2; -.
DR PathwayCommons; Q9UHA2; -.
DR SignaLink; Q9UHA2; -.
DR BioGRID-ORCS; 51188; 796 hits in 1079 CRISPR screens.
DR ChiTaRS; SS18L2; human.
DR GenomeRNAi; 51188; -.
DR Pharos; Q9UHA2; Tdark.
DR PRO; PR:Q9UHA2; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9UHA2; protein.
DR Bgee; ENSG00000008324; Expressed in secondary oocyte and 201 other tissues.
DR ExpressionAtlas; Q9UHA2; baseline and differential.
DR Genevisible; Q9UHA2; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:InterPro.
DR GO; GO:0050775; P:positive regulation of dendrite morphogenesis; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR044779; SS18.
DR InterPro; IPR007726; SS18_N.
DR PANTHER; PTHR23107; PTHR23107; 1.
DR Pfam; PF05030; SSXT; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..77
FT /note="SS18-like protein 2"
FT /id="PRO_0000181826"
FT MOTIF 50..53
FT /note="SH2-binding"
FT /evidence="ECO:0000255"
SQ SEQUENCE 77 AA; 8835 MW; 2204523E5B412BBF CRC64;
MSVAFVPDWL RGKAEVNQET IQRLLEENDQ LIRCIVEYQN KGRGNECVQY QHVLHRNLIY
LATIADASPT STSKAME
