S1A7A_HUMAN
ID S1A7A_HUMAN Reviewed; 101 AA.
AC Q86SG5; D3DV38; Q5SY69;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Protein S100-A7A;
DE AltName: Full=S100 calcium-binding protein A15;
DE AltName: Full=S100 calcium-binding protein A7-like 1;
DE AltName: Full=S100 calcium-binding protein A7A;
GN Name=S100A7A; Synonyms=S100A15, S100A7L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Epidermis;
RX PubMed=12923069; DOI=10.1096/fj.03-0148fje;
RA Wolf R., Mirmohammadsadegh A., Walz M., Lysa B., Tartler U., Remus R.,
RA Hengge U., Michel G., Ruzicka T.;
RT "Molecular cloning and characterization of alternatively spliced mRNA
RT isoforms from psoriatic skin encoding a novel member of the S100 family.";
RL FASEB J. 17:1969-1971(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENOMIC ORGANIZATION.
RX PubMed=12664160; DOI=10.1007/s00239-002-2410-5;
RA Kulski J.K., Lim C.P., Dunn D.S., Bellgard M.;
RT "Genomic and phylogenetic analysis of the S100A7 (psoriasin) gene
RT duplications within the region of the S100 gene cluster on human chromosome
RT 1q21.";
RL J. Mol. Evol. 56:397-406(2003).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS), CALCIUM-BINDING SITES, AND
RP ZINC-BINDING SITES.
RX PubMed=22747601; DOI=10.1186/1472-6807-12-16;
RA Murray J.I., Tonkin M.L., Whiting A.L., Peng F., Farnell B., Cullen J.T.,
RA Hof F., Boulanger M.J.;
RT "Structural characterization of S100A15 reveals a novel zinc coordination
RT site among S100 proteins and altered surface chemistry with functional
RT implications for receptor binding.";
RL BMC Struct. Biol. 12:16-16(2012).
CC -!- FUNCTION: May be involved in epidermal differentiation and inflammation
CC and might therefore be important for the pathogenesis of psoriasis and
CC other diseases.
CC -!- INTERACTION:
CC Q86SG5; Q5SYC1: CLVS2; NbExp=3; IntAct=EBI-13077820, EBI-12357161;
CC Q86SG5; Q5SY68: S100A7L2; NbExp=8; IntAct=EBI-13077820, EBI-12006206;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Overexpressed in psoriasis.
CC -!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY189117; AAO40032.1; -; Genomic_DNA.
DR EMBL; AY189118; AAO40033.1; -; mRNA.
DR EMBL; AY189119; AAO40034.1; -; mRNA.
DR EMBL; AL591704; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471121; EAW53328.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53329.1; -; Genomic_DNA.
DR EMBL; BR000043; FAA00014.1; -; Genomic_DNA.
DR CCDS; CCDS30872.1; -.
DR RefSeq; NP_789793.1; NM_176823.3.
DR PDB; 4AQI; X-ray; 1.70 A; A=1-101.
DR PDBsum; 4AQI; -.
DR AlphaFoldDB; Q86SG5; -.
DR SMR; Q86SG5; -.
DR BioGRID; 130711; 108.
DR IntAct; Q86SG5; 14.
DR STRING; 9606.ENSP00000357718; -.
DR GlyGen; Q86SG5; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q86SG5; -.
DR PhosphoSitePlus; Q86SG5; -.
DR BioMuta; S100A7A; -.
DR DMDM; 37088296; -.
DR jPOST; Q86SG5; -.
DR MassIVE; Q86SG5; -.
DR MaxQB; Q86SG5; -.
DR PaxDb; Q86SG5; -.
DR PeptideAtlas; Q86SG5; -.
DR PRIDE; Q86SG5; -.
DR ProteomicsDB; 69587; -.
DR Antibodypedia; 56992; 36 antibodies from 12 providers.
DR DNASU; 338324; -.
DR Ensembl; ENST00000329256.2; ENSP00000329008.2; ENSG00000184330.12.
DR Ensembl; ENST00000368728.2; ENSP00000357717.1; ENSG00000184330.12.
DR Ensembl; ENST00000368729.9; ENSP00000357718.3; ENSG00000184330.12.
DR GeneID; 338324; -.
DR KEGG; hsa:338324; -.
DR MANE-Select; ENST00000368729.9; ENSP00000357718.3; NM_176823.4; NP_789793.1.
DR UCSC; uc001fbt.1; human.
DR CTD; 338324; -.
DR DisGeNET; 338324; -.
DR GeneCards; S100A7A; -.
DR HGNC; HGNC:21657; S100A7A.
DR HPA; ENSG00000184330; Group enriched (esophagus, lymphoid tissue, skin, vagina).
DR MIM; 617427; gene.
DR neXtProt; NX_Q86SG5; -.
DR OpenTargets; ENSG00000184330; -.
DR PharmGKB; PA162402333; -.
DR VEuPathDB; HostDB:ENSG00000184330; -.
DR eggNOG; ENOG502SZJ5; Eukaryota.
DR GeneTree; ENSGT00940000163488; -.
DR HOGENOM; CLU_138624_5_0_1; -.
DR InParanoid; Q86SG5; -.
DR OrthoDB; 1486203at2759; -.
DR PhylomeDB; Q86SG5; -.
DR TreeFam; TF341148; -.
DR PathwayCommons; Q86SG5; -.
DR Reactome; R-HSA-6799990; Metal sequestration by antimicrobial proteins.
DR SignaLink; Q86SG5; -.
DR BioGRID-ORCS; 338324; 21 hits in 989 CRISPR screens.
DR ChiTaRS; S100A7A; human.
DR GeneWiki; S100A15; -.
DR GenomeRNAi; 338324; -.
DR Pharos; Q86SG5; Tbio.
DR PRO; PR:Q86SG5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q86SG5; protein.
DR Bgee; ENSG00000184330; Expressed in penis and 56 other tissues.
DR Genevisible; Q86SG5; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0048306; F:calcium-dependent protein binding; IBA:GO_Central.
DR GO; GO:0043621; F:protein self-association; IDA:MGI.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR CDD; cd00213; S-100; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR034325; S-100_dom.
DR InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR InterPro; IPR028477; S100A7.
DR PANTHER; PTHR11639:SF128; PTHR11639:SF128; 1.
DR Pfam; PF01023; S_100; 1.
DR SMART; SM01394; S_100; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00303; S100_CABP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Calcium; Cytoplasm; Metal-binding; Reference proteome;
KW Repeat; Zinc.
FT CHAIN 1..101
FT /note="Protein S100-A7A"
FT /id="PRO_0000143991"
FT DOMAIN 13..48
FT /note="EF-hand 1"
FT /evidence="ECO:0000305"
FT DOMAIN 50..85
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 18
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT BINDING 28
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT BINDING 38
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT BINDING 63
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 65
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 66
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT BINDING 67
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 69
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 74
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 87
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT BINDING 91
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT VARIANT 23
FT /note="R -> H (in dbSNP:rs55985140)"
FT /id="VAR_061048"
FT VARIANT 84
FT /note="A -> T (in dbSNP:rs3006414)"
FT /id="VAR_048468"
FT HELIX 5..20
FT /evidence="ECO:0007829|PDB:4AQI"
FT HELIX 29..39
FT /evidence="ECO:0007829|PDB:4AQI"
FT HELIX 41..49
FT /evidence="ECO:0007829|PDB:4AQI"
FT HELIX 54..62
FT /evidence="ECO:0007829|PDB:4AQI"
FT STRAND 67..70
FT /evidence="ECO:0007829|PDB:4AQI"
FT HELIX 72..90
FT /evidence="ECO:0007829|PDB:4AQI"
SQ SEQUENCE 101 AA; 11305 MW; A311A921414C9732 CRC64;
MSNTQAERSI IGMIDMFHKY TGRDGKIEKP SLLTMMKENF PNFLSACDKK GIHYLATVFE
KKDKNEDKKI DFSEFLSLLG DIAADYHKQS HGAAPCSGGS Q
