S1A7B_HUMAN
ID S1A7B_HUMAN Reviewed; 101 AA.
AC Q5SY68;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Protein S100-A7-like 2;
DE AltName: Full=S100 calcium-binding protein A7-like 2;
GN Name=S100A7L2; Synonyms=S100A7B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP IDENTIFICATION.
RX PubMed=12664160; DOI=10.1007/s00239-002-2410-5;
RA Kulski J.K., Lim C.P., Dunn D.S., Bellgard M.;
RT "Genomic and phylogenetic analysis of the S100A7 (psoriasin) gene
RT duplications within the region of the S100 gene cluster on human chromosome
RT 1q21.";
RL J. Mol. Evol. 56:397-406(2003).
CC -!- INTERACTION:
CC Q5SY68; Q9NRY6: PLSCR3; NbExp=3; IntAct=EBI-12006206, EBI-750734;
CC Q5SY68; P31151: S100A7; NbExp=10; IntAct=EBI-12006206, EBI-357520;
CC Q5SY68; Q86SG5: S100A7A; NbExp=8; IntAct=EBI-12006206, EBI-13077820;
CC -!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}.
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DR EMBL; AL591704; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BR000043; FAA00016.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5SY68; -.
DR SMR; Q5SY68; -.
DR IntAct; Q5SY68; 3.
DR STRING; 9606.ENSP00000357714; -.
DR BioMuta; S100A7L2; -.
DR DMDM; 74744045; -.
DR MassIVE; Q5SY68; -.
DR PaxDb; Q5SY68; -.
DR PeptideAtlas; Q5SY68; -.
DR PRIDE; Q5SY68; -.
DR ProteomicsDB; 64016; -.
DR Antibodypedia; 56993; 35 antibodies from 13 providers.
DR Ensembl; ENST00000368725.3; ENSP00000357714.3; ENSG00000197364.7.
DR UCSC; uc010pdx.3; human.
DR GeneCards; S100A7L2; -.
DR HGNC; HGNC:21655; S100A7L2.
DR HPA; ENSG00000197364; Not detected.
DR neXtProt; NX_Q5SY68; -.
DR VEuPathDB; HostDB:ENSG00000197364; -.
DR eggNOG; ENOG502SZJ5; Eukaryota.
DR GeneTree; ENSGT00940000165664; -.
DR HOGENOM; CLU_138624_5_0_1; -.
DR InParanoid; Q5SY68; -.
DR OMA; DVAIDYH; -.
DR PhylomeDB; Q5SY68; -.
DR PathwayCommons; Q5SY68; -.
DR SignaLink; Q5SY68; -.
DR ChiTaRS; S100A7L2; human.
DR Pharos; Q5SY68; Tdark.
DR PRO; PR:Q5SY68; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5SY68; protein.
DR Bgee; ENSG00000197364; Expressed in cell and 14 other tissues.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0048306; F:calcium-dependent protein binding; IBA:GO_Central.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR CDD; cd00213; S-100; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR034325; S-100_dom.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR Pfam; PF01023; S_100; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 1: Evidence at protein level;
KW Calcium; Metal-binding; Reference proteome; Repeat; Zinc.
FT CHAIN 1..101
FT /note="Protein S100-A7-like 2"
FT /id="PRO_0000270831"
FT DOMAIN 13..48
FT /note="EF-hand 1"
FT /evidence="ECO:0000305"
FT DOMAIN 50..85
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 63
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 65
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 67
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 69
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 74
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 87
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 91
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
SQ SEQUENCE 101 AA; 11302 MW; D49E9BEB7CFBC97C CRC64;
MNIPLGEKVM LDIVAMFRQY SGDDGRMDMP GLVNLMKENF PNFLSGCEKS DMDYLSNALE
KKDDNKDKKV NYSEFLSLLG DITIDHHKIM HGVAPCSGGS Q
