S1PBP_HUMAN
ID S1PBP_HUMAN Reviewed; 408 AA.
AC Q96BU1; B3KR04; D3DPQ5; Q5HYH3; Q9H997;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=S100P-binding protein;
DE AltName: Full=S100P-binding protein Riken;
GN Name=S100PBP {ECO:0000312|EMBL:AAH15175.1};
GN Synonyms=S100PBPR {ECO:0000303|PubMed:15632002};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAB14335.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 135-408 (ISOFORM 2).
RC TISSUE=Cerebellum, and Teratocarcinoma {ECO:0000312|EMBL:BAB14335.1};
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Heart;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3] {ECO:0000305, ECO:0000312|EMBL:CAI46038.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAH15175.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pancreas {ECO:0000312|EMBL:AAH15175.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5] {ECO:0000305}
RP INTERACTION WITH S100P, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=15632002; DOI=10.1016/s0002-9440(10)62234-1;
RA Dowen S.E., Crnogorac-Jurcevic T., Gangeswaran R., Hansen M.,
RA Eloranta J.J., Bhakta V., Brentnall T.A., Luettges J., Kloeppel G.,
RA Lemoine N.R.;
RT "Expression of S100P and its novel binding partner S100PBPR in early
RT pancreatic cancer.";
RL Am. J. Pathol. 166:81-92(2005).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=18089492; DOI=10.1309/5d76nde81le8g545;
RA Deng H., Shi J., Wilkerson M., Meschter S., Dupree W., Lin F.;
RT "Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-
RT needle aspiration biopsy specimens.";
RL Am. J. Clin. Pathol. 129:81-88(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- SUBUNIT: Interacts with S100P. {ECO:0000269|PubMed:15632002}.
CC -!- INTERACTION:
CC Q96BU1; O43809: NUDT21; NbExp=3; IntAct=EBI-18959794, EBI-355720;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15632002}.
CC Note=Colocalizes with S100P in the nucleus.
CC {ECO:0000269|PubMed:15632002}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:15489334};
CC IsoId=Q96BU1-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:14702039};
CC IsoId=Q96BU1-2; Sequence=VSP_052661;
CC -!- TISSUE SPECIFICITY: Expressed in brain, spleen, and lung. Not detected
CC in pancreas or liver. In pancreas, expressed predominantly in islet
CC cells and to a lesser extent in acinar cells, but not expressed in
CC ductal cells. Up-regulated in various pancreatic ductal adenocarcinomas
CC and pancreatic intraepithelial neoplasias. Detected in pancreatic
CC ductal adenocarcinoma cells (at protein level). Not detected in non-
CC neoplastic ductal epithelium (at protein level).
CC {ECO:0000269|PubMed:15632002, ECO:0000269|PubMed:18089492}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB14335.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/S100PBPID44308ch1p35.html";
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DR EMBL; AK022965; BAB14335.1; ALT_INIT; mRNA.
DR EMBL; AK090711; BAG52216.1; -; mRNA.
DR EMBL; BX647667; CAI46038.1; -; mRNA.
DR EMBL; CH471059; EAX07503.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX07504.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX07505.1; -; Genomic_DNA.
DR EMBL; BC015175; AAH15175.1; -; mRNA.
DR CCDS; CCDS30666.1; -. [Q96BU1-1]
DR RefSeq; NP_001243050.1; NM_001256121.1. [Q96BU1-1]
DR RefSeq; NP_073590.2; NM_022753.3. [Q96BU1-1]
DR RefSeq; XP_011540263.1; XM_011541961.2. [Q96BU1-1]
DR RefSeq; XP_011540264.1; XM_011541962.2. [Q96BU1-1]
DR AlphaFoldDB; Q96BU1; -.
DR BioGRID; 122278; 5.
DR IntAct; Q96BU1; 3.
DR STRING; 9606.ENSP00000362574; -.
DR CarbonylDB; Q96BU1; -.
DR iPTMnet; Q96BU1; -.
DR PhosphoSitePlus; Q96BU1; -.
DR BioMuta; S100PBP; -.
DR DMDM; 74731274; -.
DR EPD; Q96BU1; -.
DR jPOST; Q96BU1; -.
DR MassIVE; Q96BU1; -.
DR MaxQB; Q96BU1; -.
DR PaxDb; Q96BU1; -.
DR PeptideAtlas; Q96BU1; -.
DR PRIDE; Q96BU1; -.
DR ProteomicsDB; 76116; -. [Q96BU1-1]
DR ProteomicsDB; 76117; -. [Q96BU1-2]
DR Antibodypedia; 31365; 118 antibodies from 20 providers.
DR DNASU; 64766; -.
DR Ensembl; ENST00000373475.10; ENSP00000362574.5; ENSG00000116497.18. [Q96BU1-1]
DR Ensembl; ENST00000373476.5; ENSP00000362575.1; ENSG00000116497.18. [Q96BU1-1]
DR GeneID; 64766; -.
DR KEGG; hsa:64766; -.
DR MANE-Select; ENST00000373475.10; ENSP00000362574.5; NM_022753.4; NP_073590.2.
DR UCSC; uc001bvz.5; human. [Q96BU1-1]
DR CTD; 64766; -.
DR DisGeNET; 64766; -.
DR GeneCards; S100PBP; -.
DR HGNC; HGNC:25768; S100PBP.
DR HPA; ENSG00000116497; Low tissue specificity.
DR MIM; 611889; gene.
DR neXtProt; NX_Q96BU1; -.
DR OpenTargets; ENSG00000116497; -.
DR PharmGKB; PA142670958; -.
DR VEuPathDB; HostDB:ENSG00000116497; -.
DR eggNOG; ENOG502S5YT; Eukaryota.
DR GeneTree; ENSGT00390000007209; -.
DR HOGENOM; CLU_064425_0_0_1; -.
DR InParanoid; Q96BU1; -.
DR OMA; HHMQNSK; -.
DR OrthoDB; 907110at2759; -.
DR PhylomeDB; Q96BU1; -.
DR TreeFam; TF337946; -.
DR PathwayCommons; Q96BU1; -.
DR SignaLink; Q96BU1; -.
DR BioGRID-ORCS; 64766; 13 hits in 1081 CRISPR screens.
DR ChiTaRS; S100PBP; human.
DR GenomeRNAi; 64766; -.
DR Pharos; Q96BU1; Tbio.
DR PRO; PR:Q96BU1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96BU1; protein.
DR Bgee; ENSG00000116497; Expressed in right testis and 181 other tissues.
DR ExpressionAtlas; Q96BU1; baseline and differential.
DR Genevisible; Q96BU1; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0016607; C:nuclear speck; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:HGNC-UCL.
DR GO; GO:0048306; F:calcium-dependent protein binding; IPI:HGNC-UCL.
DR InterPro; IPR026097; S100PBP.
DR PANTHER; PTHR14455; PTHR14455; 1.
DR Pfam; PF15427; S100PBPR; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..408
FT /note="S100P-binding protein"
FT /id="PRO_0000317051"
FT REGION 1..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..63
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..92
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 187
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 343..408
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_052661"
FT CONFLICT 329
FT /note="V -> L (in Ref. 1; BAB14335)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 408 AA; 45582 MW; C366D258BEF3AAF5 CRC64;
MMCSRVPSEQ SSGTSLLPKD GAPFSWDSLD EDGLDDSLLE LSEGEEDDGD VNYTEEEIDA
LLKEDDPSYE QSSGEDDGGH VEKGERGSQI LLDTPREKNS SYSLGPVAET PDLFKLPQLS
TSSGHGPAHT KPLNRRSVLE KNLIKVTVAP FNPTVCDALL DKDETDSSKD TEKLSSLGEE
MREDGLSPNE SKLCTESEGI SPNNSAWNGP QLSSSNNNFQ QTVSDKNMPD SENPTSVFSR
ISDHSETPNM ELSCRNGGSH KSSCEMRSLV VSTSSNKQDV LNKDSGKMKG HERRLGKVIP
VLQTKTRTNV PTFSQSNLEQ QKQLYLRSVI AHIEDPEDTN QGISGELCAL MDQVHHMQHS
KWQHPSDLTT RNYARRQKHL QRYSLTQWVD RNMRSHHRFQ RLPDFSYS
