S1PBP_MOUSE
ID S1PBP_MOUSE Reviewed; 396 AA.
AC Q9D5K4; A2A7S5; Q3UJU0; Q3UTU1; Q3V367; Q8BSS8; Q8C925; Q8CHX8;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=S100P-binding protein;
GN Name=S100pbp {ECO:0000312|MGI:MGI:1921898};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAB29757.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 5).
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB29757.1}, and
RC DBA/2J {ECO:0000312|EMBL:BAE27065.1};
RC TISSUE=Cerebellum {ECO:0000312|EMBL:BAE23889.1},
RC Pituitary {ECO:0000312|EMBL:BAC27057.1},
RC Testis {ECO:0000312|EMBL:BAB29757.1}, and
RC Thymus {ECO:0000312|EMBL:BAE20659.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAH38329.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Mammary gland {ECO:0000312|EMBL:AAH38329.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Interacts with S100P. {ECO:0000250|UniProtKB:Q96BU1}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96BU1}.
CC Note=Colocalizes with S100P in the nucleus.
CC {ECO:0000250|UniProtKB:Q96BU1}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1 {ECO:0000269|PubMed:16141072};
CC IsoId=Q9D5K4-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:16141072};
CC IsoId=Q9D5K4-2; Sequence=VSP_052667, VSP_052668;
CC Name=3 {ECO:0000269|PubMed:16141072};
CC IsoId=Q9D5K4-3; Sequence=VSP_052663, VSP_052664;
CC Name=4 {ECO:0000269|PubMed:15489334};
CC IsoId=Q9D5K4-4; Sequence=VSP_052662, VSP_052664;
CC Name=5 {ECO:0000269|PubMed:16141072};
CC IsoId=Q9D5K4-5; Sequence=VSP_052663, VSP_052664, VSP_052665,
CC VSP_052666;
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DR EMBL; AK015229; BAB29757.1; -; mRNA.
DR EMBL; AK030636; BAC27057.1; -; mRNA.
DR EMBL; AK043160; BAC31481.1; -; mRNA.
DR EMBL; AK046756; BAE20659.1; -; mRNA.
DR EMBL; AK139097; BAE23889.1; -; mRNA.
DR EMBL; AK146310; BAE27065.1; -; mRNA.
DR EMBL; AL606977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC038329; AAH38329.1; -; mRNA.
DR CCDS; CCDS18684.1; -. [Q9D5K4-1]
DR CCDS; CCDS84797.1; -. [Q9D5K4-4]
DR CCDS; CCDS89830.1; -. [Q9D5K4-3]
DR RefSeq; NP_001334132.1; NM_001347203.1. [Q9D5K4-4]
DR RefSeq; NP_083312.1; NM_029036.2. [Q9D5K4-1]
DR RefSeq; XP_006503508.1; XM_006503445.3.
DR RefSeq; XP_006503509.1; XM_006503446.3. [Q9D5K4-1]
DR RefSeq; XP_006503511.1; XM_006503448.2. [Q9D5K4-1]
DR RefSeq; XP_006503512.1; XM_006503449.3.
DR RefSeq; XP_011238925.1; XM_011240623.2.
DR AlphaFoldDB; Q9D5K4; -.
DR STRING; 10090.ENSMUSP00000101676; -.
DR iPTMnet; Q9D5K4; -.
DR PhosphoSitePlus; Q9D5K4; -.
DR EPD; Q9D5K4; -.
DR MaxQB; Q9D5K4; -.
DR PaxDb; Q9D5K4; -.
DR PeptideAtlas; Q9D5K4; -.
DR PRIDE; Q9D5K4; -.
DR ProteomicsDB; 260877; -. [Q9D5K4-1]
DR ProteomicsDB; 260878; -. [Q9D5K4-2]
DR ProteomicsDB; 260879; -. [Q9D5K4-3]
DR ProteomicsDB; 260880; -. [Q9D5K4-4]
DR ProteomicsDB; 260881; -. [Q9D5K4-5]
DR Antibodypedia; 31365; 118 antibodies from 20 providers.
DR DNASU; 74648; -.
DR Ensembl; ENSMUST00000049081; ENSMUSP00000039820; ENSMUSG00000040928. [Q9D5K4-1]
DR Ensembl; ENSMUST00000072431; ENSMUSP00000072258; ENSMUSG00000040928. [Q9D5K4-3]
DR Ensembl; ENSMUST00000106059; ENSMUSP00000101674; ENSMUSG00000040928. [Q9D5K4-4]
DR Ensembl; ENSMUST00000106061; ENSMUSP00000101676; ENSMUSG00000040928. [Q9D5K4-1]
DR Ensembl; ENSMUST00000117350; ENSMUSP00000113214; ENSMUSG00000040928. [Q9D5K4-2]
DR GeneID; 74648; -.
DR KEGG; mmu:74648; -.
DR UCSC; uc008uwf.1; mouse. [Q9D5K4-1]
DR UCSC; uc008uwg.1; mouse. [Q9D5K4-4]
DR UCSC; uc008uwh.1; mouse. [Q9D5K4-3]
DR UCSC; uc008uwj.1; mouse. [Q9D5K4-2]
DR CTD; 64766; -.
DR MGI; MGI:1921898; S100pbp.
DR VEuPathDB; HostDB:ENSMUSG00000040928; -.
DR eggNOG; ENOG502S5YT; Eukaryota.
DR GeneTree; ENSGT00390000007209; -.
DR HOGENOM; CLU_064425_0_0_1; -.
DR InParanoid; Q9D5K4; -.
DR OMA; HHMQNSK; -.
DR OrthoDB; 907110at2759; -.
DR PhylomeDB; Q9D5K4; -.
DR TreeFam; TF337946; -.
DR BioGRID-ORCS; 74648; 7 hits in 73 CRISPR screens.
DR ChiTaRS; S100pbp; mouse.
DR PRO; PR:Q9D5K4; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9D5K4; protein.
DR Bgee; ENSMUSG00000040928; Expressed in embryonic post-anal tail and 240 other tissues.
DR ExpressionAtlas; Q9D5K4; baseline and differential.
DR Genevisible; Q9D5K4; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0048306; F:calcium-dependent protein binding; ISO:MGI.
DR InterPro; IPR026097; S100PBP.
DR PANTHER; PTHR14455; PTHR14455; 1.
DR Pfam; PF15427; S100PBPR; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..396
FT /note="S100P-binding protein"
FT /id="PRO_0000317052"
FT REGION 145..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 67..143
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_052662"
FT VAR_SEQ 108..144
FT /note="STSVGHGPTPSKSLNRHFVLEKNLIKVTVVAPFNPTV -> I (in
FT isoform 3 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_052663"
FT VAR_SEQ 189..230
FT /note="Missing (in isoform 3, isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_052664"
FT VAR_SEQ 264..290
FT /note="HAFDKDSGEAKGERRLGKVIPVLQTRT -> VSTFFQDIVERKLFSFRKNSY
FT VLNFHI (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_052665"
FT VAR_SEQ 291..396
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_052666"
FT VAR_SEQ 323..371
FT /note="TLGELDALMDQVHMQHPDWQHPSDLTTRNYARFRQRPLQRYSLSQWVDR ->
FT NMATKEWLIKHGFRHFLSMIMSLNWDVLNFLKLMKKKTSLSKDLFRRVL (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_052667"
FT VAR_SEQ 372..396
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_052668"
FT CONFLICT 97
FT /note="E -> K (in Ref. 1; BAE27065)"
FT /evidence="ECO:0000305"
FT CONFLICT 262
FT /note="N -> K (in Ref. 1; BAE20659)"
FT /evidence="ECO:0000305"
FT CONFLICT 265
FT /note="A -> V (in Ref. 1; BAC27057)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 396 AA; 44473 MW; B8FF359970F9C768 CRC64;
MTCSLLPSEQ SSGASFLPKS NASFPWGSLD EDELDDSLLE FSDGEEDDGH FSFTEEEIEM
LLKDDDGGHN EYRPRKSQIL PDIPQENSLY SLGPAAETPG FLKLPQLSTS VGHGPTPSKS
LNRHFVLEKN LIKVTVVAPF NPTVCDPVLD KDKIDSSKET ENPASLREQT REDDPQPNES
KRCTEPEGVS PNTSAWDGPL LSSPSNNNIE QTASDKNIPE SKKPTPVFSQ ISNHSEVPNR
KNSGSHKSGC EVRIPVVSSS SNRHAFDKDS GEAKGERRLG KVIPVLQTRT RMFSQSELEK
QKDIYLSKVI AHIEDPGDSN QGTLGELDAL MDQVHMQHPD WQHPSDLTTR NYARFRQRPL
QRYSLSQWVD RNKRSHHRFQ RLPDFSYSPY VSSHQQ
