ID   BELY_TRIVA              Reviewed;         458 AA.
AC   A2EYC4;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Probable beta-eliminating lyase;
DE            EC=4.1.99.-;
GN   ORFNames=TVAG_054490;
OS   Trichomonas vaginalis.
OC   Eukaryota; Metamonada; Parabasalia; Trichomonadida; Trichomonadidae;
OC   Trichomonas.
OX   NCBI_TaxID=5722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC PRA-98 / G3;
RX   PubMed=17218520; DOI=10.1126/science.1132894;
RA   Carlton J.M., Hirt R.P., Silva J.C., Delcher A.L., Schatz M., Zhao Q.,
RA   Wortman J.R., Bidwell S.L., Alsmark U.C.M., Besteiro S.,
RA   Sicheritz-Ponten T., Noel C.J., Dacks J.B., Foster P.G., Simillion C.,
RA   Van de Peer Y., Miranda-Saavedra D., Barton G.J., Westrop G.D., Mueller S.,
RA   Dessi D., Fiori P.L., Ren Q., Paulsen I., Zhang H., Bastida-Corcuera F.D.,
RA   Simoes-Barbosa A., Brown M.T., Hayes R.D., Mukherjee M., Okumura C.Y.,
RA   Schneider R., Smith A.J., Vanacova S., Villalvazo M., Haas B.J., Pertea M.,
RA   Feldblyum T.V., Utterback T.R., Shu C.L., Osoegawa K., de Jong P.J.,
RA   Hrdy I., Horvathova L., Zubacova Z., Dolezal P., Malik S.B.,
RA   Logsdon J.M. Jr., Henze K., Gupta A., Wang C.C., Dunne R.L., Upcroft J.A.,
RA   Upcroft P., White O., Salzberg S.L., Tang P., Chiu C.-H., Lee Y.-S.,
RA   Embley T.M., Coombs G.H., Mottram J.C., Tachezy J., Fraser-Liggett C.M.,
RA   Johnson P.J.;
RT   "Draft genome sequence of the sexually transmitted pathogen Trichomonas
RT   vaginalis.";
RL   Science 315:207-212(2007).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the beta-eliminating lyase family.
CC       {ECO:0000305}.
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DR   EMBL; DS113539; EAY02351.1; -; Genomic_DNA.
DR   RefSeq; XP_001330618.1; XM_001330582.1.
DR   AlphaFoldDB; A2EYC4; -.
DR   SMR; A2EYC4; -.
DR   STRING; 5722.XP_001330618.1; -.
DR   PRIDE; A2EYC4; -.
DR   GeneID; 4760188; -.
DR   KEGG; tva:TVAG_054490; -.
DR   VEuPathDB; TrichDB:TVAG_054490; -.
DR   eggNOG; ENOG502QU0C; Eukaryota.
DR   InParanoid; A2EYC4; -.
DR   OMA; EMYQYGD; -.
DR   Proteomes; UP000001542; Unassembled WGS sequence.
DR   GO; GO:0016830; F:carbon-carbon lyase activity; IEA:InterPro.
DR   GO; GO:0009072; P:aromatic amino acid family metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.640.10; -; 1.
DR   Gene3D; 3.90.1150.10; -; 1.
DR   InterPro; IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
DR   InterPro; IPR011166; Beta-eliminating_lyase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   InterPro; IPR018176; Tryptophanase_CS.
DR   Pfam; PF01212; Beta_elim_lyase; 1.
DR   PIRSF; PIRSF001386; Trpase; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
DR   PROSITE; PS00853; BETA_ELIM_LYASE; 1.
PE   3: Inferred from homology;
KW   Lyase; Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..458
FT                   /note="Probable beta-eliminating lyase"
FT                   /id="PRO_0000330815"
FT   MOD_RES         257
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   458 AA;  52097 MW;  1D6E97BDFDFC8C74 CRC64;
     MELPFAESWK IKMVEPIHKS TREQREQWLK EAHYNVFQLT ADKVYIDLLT DSGTGAMSDR
     QWSALMMGDE SYAGASSFLK LKETITKITG FDYILPTHQG RAAENVLFSY LVKQGDIVPG
     NSHFDTTKGH IESRHATALD CTVDIAKDTQ AEYPFKGNVD IKKLEKALEE NKDKIPFIII
     TITNNTAGGQ PVSMANLREV RELADKYKKP VLFDSARFAE NAYFIKVREE GYANKTIKEI
     CLEMFKYADG MTMSAKKDGL VNIGGFIATR LKEWYEGAKS YCIMYEGYLT YGGMAGRDMS
     ALAAGLEENT EFEMLETRIK QVEYLAKRLD EYGIPYQRPA GGHAIFLDAR KILTHVPAEE
     FPAQTLTVEL YLEAGIRGVE IGYILADRDP VTRENRFGGL DLLRLAIPRR VYTDNHMNVV
     AVALKNVFDR REKITRGVKI TWEAEIMRHF TVQLERLQ