ID   S1PR3_TAKRU             Reviewed;         384 AA.
AC   Q9PUQ8;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Sphingosine 1-phosphate receptor 3;
DE            Short=S1P receptor 3;
DE            Short=S1P3;
DE   AltName: Full=Sphingosine 1-phosphate receptor Edg-3;
DE            Short=S1P receptor Edg-3;
GN   Name=s1pr3; Synonyms=edg3;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10508926; DOI=10.1016/s0014-5793(99)01210-7;
RA   Yamaguchi F., Yamaguchi K., Tokuda M., Brenner S.;
RT   "Molecular cloning of EDG-3 and N-Shc genes from the puffer fish, Fugu
RT   rubripes, and conservation of synteny with the human genome.";
RL   FEBS Lett. 459:105-110(1999).
CC   -!- FUNCTION: Receptor for the lysosphingolipid sphingosine 1-phosphate
CC       (S1P). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF164114; AAF07896.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9PUQ8; -.
DR   SMR; Q9PUQ8; -.
DR   InParanoid; Q9PUQ8; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0038036; F:sphingosine-1-phosphate receptor activity; IEA:InterPro.
DR   InterPro; IPR004062; EDG3_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR004061; S1P_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR01524; EDG3RECEPTOR.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01523; S1PRECEPTOR.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..384
FT                   /note="Sphingosine 1-phosphate receptor 3"
FT                   /id="PRO_0000069423"
FT   TOPO_DOM        1..34
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        35..55
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        56..64
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        65..85
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        86..105
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        106..126
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        127..144
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        145..165
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        166..186
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        187..207
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        208..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        236..256
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        257..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        293..384
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   REGION          315..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        315..348
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        12
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   384 AA;  42712 MW;  92B0DDF6BBD0E3BF CRC64;
     MMINPLIYLH YNYTGKLDHR PTVGTSPGTR DPKTIAFLVV CSFIILENLT VLLAIWKNHR
     FHNRMYFFIG NLALCDLLAS VAYLVNLLLS GEKTLQLSPV LWFVREGSMF VTLGASIFSL
     LAIAIERHLT MIKMRPYDAS KNYRVFLLIG TCWLVAVLLG ALPILGWNCL GNLPDCSTIL
     PLYTKKYVAF CIIVFIVLLL AMSVLYARIY ILVKSSSQKV SKHRNSEHAM SLLRTVIIVV
     GVFIACWMPI FVLLLLDVAC ERPCPILYKA DWFIAVAVLN SAMNPIIYTL ASREMRRAFL
     GLVCGVCYRG NGSGNDSGNK QFQEPSRSRS KSWSSQTHPN QSQQSSRPAE LDREQETGHG
     EISVVAGGAA QASQREGEGG NGGR