S1PR4_MOUSE
ID S1PR4_MOUSE Reviewed; 386 AA.
AC Q9Z0L1; Q3U4H3; Q8C6E2; Q8K1R9;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Sphingosine 1-phosphate receptor 4;
DE Short=S1P receptor 4;
DE Short=S1P4;
DE AltName: Full=Endothelial differentiation G-protein coupled receptor 6;
DE AltName: Full=Lysophospholipid receptor C1;
DE AltName: Full=Sphingosine 1-phosphate receptor Edg-6;
DE Short=S1P receptor Edg-6;
GN Name=S1pr4; Synonyms=Edg6, Lpc1, S1p4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Fetal skin;
RX PubMed=9790765; DOI=10.1006/geno.1998.5491;
RA Graeler M.H., Bernhardt G., Lipp M.;
RT "EDG6, a novel G protein-coupled receptor related to receptors for
RT bioactive lysophospholipids, is specifically expressed in lymphoid
RT tissue.";
RL Genomics 53:164-169(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX PubMed=12401211; DOI=10.1016/s0014-5793(02)03409-9;
RA Contos J.J.A., Ye X., Sah V.P., Chun J.;
RT "Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled
RT receptor (s1p(4)/lp(C1)/Edg6) gene.";
RL FEBS Lett. 531:99-102(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD; TISSUE=Dendritic cell;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for the lysosphingolipid sphingosine 1-phosphate
CC (S1P). S1P is a bioactive lysophospholipid that elicits diverse
CC physiological effect on most types of cells and tissues. May be
CC involved in cell migration processes that are specific for lymphocytes
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Specifically expressed in fetal and adult lymphoid
CC and hematopoietic tissue. Expressed in lung, spleen, thymus and lymph
CC node but absent in other non-lymphatic tissue. Coexpressed with GNA15
CC at the same relative levels in all tissues examined, with the highest
CC levels in adult spleen and lung. {ECO:0000269|PubMed:12401211}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AJ006074; CAA06847.1; -; mRNA.
DR EMBL; AJ489247; CAD33254.1; -; Genomic_DNA.
DR EMBL; AK154242; BAE32458.1; -; mRNA.
DR EMBL; BC107000; AAI07001.1; -; mRNA.
DR CCDS; CCDS24059.1; -.
DR RefSeq; NP_034232.1; NM_010102.2.
DR AlphaFoldDB; Q9Z0L1; -.
DR SMR; Q9Z0L1; -.
DR STRING; 10090.ENSMUSP00000050412; -.
DR GuidetoPHARMACOLOGY; 278; -.
DR GlyGen; Q9Z0L1; 2 sites.
DR PhosphoSitePlus; Q9Z0L1; -.
DR PaxDb; Q9Z0L1; -.
DR PRIDE; Q9Z0L1; -.
DR ProteomicsDB; 256666; -.
DR Antibodypedia; 10967; 390 antibodies from 37 providers.
DR DNASU; 13611; -.
DR Ensembl; ENSMUST00000053646; ENSMUSP00000050412; ENSMUSG00000044199.
DR GeneID; 13611; -.
DR KEGG; mmu:13611; -.
DR UCSC; uc007gih.2; mouse.
DR CTD; 8698; -.
DR MGI; MGI:1333809; S1pr4.
DR VEuPathDB; HostDB:ENSMUSG00000044199; -.
DR eggNOG; ENOG502QQUE; Eukaryota.
DR GeneTree; ENSGT01050000244887; -.
DR HOGENOM; CLU_047979_1_1_1; -.
DR InParanoid; Q9Z0L1; -.
DR OMA; MLCWGPL; -.
DR OrthoDB; 981486at2759; -.
DR PhylomeDB; Q9Z0L1; -.
DR TreeFam; TF330052; -.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR Reactome; R-MMU-419408; Lysosphingolipid and LPA receptors.
DR BioGRID-ORCS; 13611; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q9Z0L1; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9Z0L1; protein.
DR Bgee; ENSMUSG00000044199; Expressed in granulocyte and 82 other tissues.
DR Genevisible; Q9Z0L1; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:MGI.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0038036; F:sphingosine-1-phosphate receptor activity; IEA:InterPro.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:MGI.
DR GO; GO:0019222; P:regulation of metabolic process; IBA:GO_Central.
DR InterPro; IPR004064; EDG6_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004061; S1P_rcpt.
DR PANTHER; PTHR22750:SF13; PTHR22750:SF13; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01526; EDG6RECEPTOR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01523; S1PRECEPTOR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Lipoprotein;
KW Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..386
FT /note="Sphingosine 1-phosphate receptor 4"
FT /id="PRO_0000069432"
FT TOPO_DOM 1..56
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 57..77
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250"
FT TOPO_DOM 78..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 88..108
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250"
FT TOPO_DOM 109..120
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 121..141
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250"
FT TOPO_DOM 142..163
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 164..184
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250"
FT TOPO_DOM 185..208
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 209..229
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250"
FT TOPO_DOM 230..254
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 255..275
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250"
FT TOPO_DOM 276..290
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 291..311
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250"
FT TOPO_DOM 312..386
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT LIPID 325
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 32
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 146
FT /note="R -> A (in Ref. 2; CAD33254)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 386 AA; 42263 MW; 8AB32CB602BA9922 CRC64;
MNISTWSTLV TPESCHRLAA SGHSLLIVLH YNHSGRLASR GGSEDGGGLG MLRGPSVAAG
CLVVLENAMV LAAIAIYMRS RRWVYYCLLN ITLSDLLTGL AYVVNVLLSG TRTFQLSPVH
WFLREGLLFM ALAASTFSLL FTAGERFATM VRVAESGATK TSRVYGCIGL CWLLAAILGL
LPLLGWNCVC AFPRCSSLLP LYSKGYVLFC VVVFALILVA ILSLYGAIFR VVRANGQKSP
RPPARRKSRR LLNTVLMILV AFVVCWGPLF GLLLADIFGS NVWAQEYLRG MDWILALAVF
NSAINPLIYS FRSREVQRAV LAFLCCGCLW LGLRGPGDCL TRITEAHSGA STTDSSLRPR
DSFRTSRSLS FRMREPLSSI SSVRST
