ABCGF_DICDI
ID ABCGF_DICDI Reviewed; 1475 AA.
AC Q55GB1; Q8T678;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=ABC transporter G family member 15;
DE AltName: Full=ABC transporter ABCG.15;
GN Name=abcG15; ORFNames=DDB_G0267432;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
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DR EMBL; AF482393; AAL91500.1; -; Genomic_DNA.
DR EMBL; AAFI02000003; EAL73168.1; -; Genomic_DNA.
DR RefSeq; XP_647273.1; XM_642181.1.
DR AlphaFoldDB; Q55GB1; -.
DR SMR; Q55GB1; -.
DR STRING; 44689.DDB0191235; -.
DR PaxDb; Q55GB1; -.
DR EnsemblProtists; EAL73168; EAL73168; DDB_G0267432.
DR GeneID; 8616080; -.
DR KEGG; ddi:DDB_G0267432; -.
DR dictyBase; DDB_G0267432; abcG15.
DR eggNOG; KOG0065; Eukaryota.
DR HOGENOM; CLU_000604_35_0_1; -.
DR InParanoid; Q55GB1; -.
DR OMA; TGFVIRI; -.
DR PhylomeDB; Q55GB1; -.
DR PRO; PR:Q55GB1; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0031152; P:aggregation involved in sorocarp development; IBA:GO_Central.
DR GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010929; PDR_CDR_ABC.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF06422; PDR_CDR; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Membrane; Nucleotide-binding; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1475
FT /note="ABC transporter G family member 15"
FT /id="PRO_0000391401"
FT TRANSMEM 596..616
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 623..641
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 653..673
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 680..699
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 770..790
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1180..1200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1216..1236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1256..1276
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1293..1313
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1323..1343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1449..1469
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 155..404
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 507..753
FT /note="ABC transmembrane type-2 1"
FT DOMAIN 842..1087
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1180..1404
FT /note="ABC transmembrane type-2 2"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 25..67
FT /evidence="ECO:0000255"
FT COMPBIAS 10..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 879..886
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 15
FT /note="E -> K (in Ref. 1; AAL91500)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1475 AA; 166860 MW; B1F38AAF8516A53E CRC64;
MDSNENKKNG GDSLELNIIN NNNDNNNNND NNNNSTEEHI ESVEQSIKEF NNVANELETE
FRDYLVETHK NDVNNIKNDI EAPPSGEFEP GGGAEDEDFK LRNYFKQSKV DAIQNGGKLK
KMGVSFKNLT VIGKGADQSV VSDLATPFTF LISKLNVKNW FKKSKPSTFD ILHDVSGFCK
DGEMLLVLGR PGSGCSSLLR TISNQTGSYV DVLGSVTYGG IDQKKWDKYK AECIYVPEED
THYPTLTVRE TLEFALKCKT PSNRLPNEKK RTFRSKIFNL LLGMFGMVHQ AETMVGNEFV
RGLSGGERKR ITIAESMVSA SSINCYDCST RGLDAASALD YAKSIRIMSD TLHKTTIASF
YQASDSIYNL FDRVLILEKG RCVYFGPVGL AKQYFIDMGF ECEPRKSTPD FLTGVTNPQE
RKVRPGFTVP ESSAEFEEAW KQSEIYAQSC QEQREYEKLI EIEQPSIDFI QEITEQKSKS
TSKSSPYTTG FFVQVIALTI RNFQIIWGDK FSLISRYSSV LVQAPIYGSV FFAMSNSIDG
AFTRGGAIFS SILFNALLSE QELSITFTGR RILQKHKTYA MYRPAALHFA QIITEIPIIM
IQVFLFSIVT YFMFGLDSSG SKFFINCFTL IGFTLATNNL YRLAGNLTPS VYIGQNIMNV
LFLTMMTFTS YIIPYHQMPV WFGWYHYCNP FSFAFRALMG NEFNGLKFDC IEDAIPKGEF
YQNETFTPYR SCATTAAEPG QLYFTGERYL EKSFGWEIKP STQGFIAYNI CIVYGFWILF
IICNCIVLNI IDWTSGGFTC KVYLKGKAPK MNDVENEKQQ NLLVQQATNN MKESLSMPGG
LFTWQHMYYS VPIGGNTMKL LLDDIQGWIK PGQMTALMGS SGAGKTTLLD VLAKRKTTGQ
VQGTTLLNGK PLEIDFERIT GYVEQMDVLN PALTVRETLR FSAKLRGEPT ISLEEKFKYV
EQVLEMMEMK HLGDALIGDL ETGVGISVEE RKRTTIGVEL VAKPHILFLD EPTSGLDAQS
SYNIIKFIRK LADAGMPLVC TIHQPSSVLF EHFDRILLLA KGGKTVYFGD IGEKSKTLTS
YFQRHGVREC SDSENPAEYI LEACGAGRHG KSVVDWPQAW KESPEYQSIC QELKELQVTG
SSYASIHVDN GKPREYATSL TYQTIEVYKR LNLIWWRSPG YSYGTFIQSA LVGLINGWTF
YNLQDSANDM NQRIFFIFNV TMLGILLMFL VLPQFITQQD YFKRDYASKF YHWLPFALSI
IVVELPFVLV SGTIFFFCSF WTAGLNSDAS TNFFFWLIFM LFLFYCVGFG QAIGAVCINI
TVALNLLPVL IIFLFLFCGV LVIPDQIPHF WKWVYHLNPC THFLEAMVTN VLKHVNVVCT
TDDLIKFVKP SSFSTCSDYA FEFLNGSNHS VSGSVQSLGG DNCGYCLYKN GEEYYSKLGW
SYDNRWRGFG IIAGYFVLNI FLVVLFVFLT RKGKR
