S1_BPMU
ID S1_BPMU Reviewed; 504 AA.
AC Q9T1V0;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 23-FEB-2022, entry version 73.
DE RecName: Full=Tail fiber protein S;
DE AltName: Full=Gene product 49;
DE Short=gp49;
DE AltName: Full=Gene product S;
DE Short=gpS;
GN Name=S; OrderedLocusNames=Mup49;
OS Escherichia phage Mu (Bacteriophage Mu).
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Caudovirales; Myoviridae; Muvirus.
OX NCBI_TaxID=10677;
OH NCBI_TaxID=543; Enterobacteriaceae.
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11922669; DOI=10.1006/jmbi.2002.5437;
RA Morgan G.J., Hatfull G.F., Casjens S., Hendrix R.W.;
RT "Bacteriophage Mu genome sequence: analysis and comparison with Mu-like
RT prophages in Haemophilus, Neisseria and Deinococcus.";
RL J. Mol. Biol. 317:337-359(2002).
RN [2]
RP FUNCTION.
RX PubMed=6250048; DOI=10.1038/286218a0;
RA van de Putte P., Cramer S., Giphart-Gassler M.;
RT "Invertible DNA determines host specificity of bacteriophage mu.";
RL Nature 286:218-222(1980).
RN [3]
RP DISRUPTION PHENOTYPE.
RX PubMed=3904174; DOI=10.1016/0042-6822(85)90388-5;
RA Grundy F.J., Howe M.M.;
RT "Morphogenetic structures present in lysates of amber mutants of
RT bacteriophage Mu.";
RL Virology 143:485-504(1985).
RN [4]
RP INDUCTION.
RX PubMed=8293968; DOI=10.1093/genetics/135.3.619;
RA Chiang L.W., Howe M.M.;
RT "Mutational analysis of a C-dependent late promoter of bacteriophage Mu.";
RL Genetics 135:619-629(1993).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=8599204; DOI=10.1006/viro.1996.0107;
RA Grimaud R.;
RT "Bacteriophage Mu head assembly.";
RL Virology 217:200-210(1996).
CC -!- FUNCTION: Component of the tail fiber that acts as receptor binding
CC protein. Binds to the primary receptor, thereby determining the host
CC range. Two alternate tail fiber S and S' proteins are encoded extending
CC the host range of the virus. {ECO:0000269|PubMed:6250048}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:8599204}. Host
CC cytoplasm {ECO:0000305|PubMed:8599204}. Note=Tail fiber.
CC -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC Expression of late genes is activated by the viral late transcription
CC activator C. Expressed alternatively with tail fiber protein S'
CC (associated with tail fiber assembly protein U'). The switch from S-U
CC to S'-U' occurs through inversion of a DNA segment called G by the
CC phage invertase protein Gin. {ECO:0000269|PubMed:8293968}.
CC -!- DISRUPTION PHENOTYPE: Viral particles lack tail fibers in inversion-
CC defective gin mutants (blocked in G+ orientation; no switch to S'-U').
CC {ECO:0000269|PubMed:3904174}.
CC -!- MISCELLANEOUS: The orientation of the G segment is defined as G+ and
CC G-. G+ orientation provides S-U fibers whereas G- provides S'-U'
CC fibers. S-U and S'-U' dont have the same host range (e.g. respectively
CC E.coli and C.freundii).
CC -!- SIMILARITY: Belongs to the caudovirales tail fiber protein family.
CC {ECO:0000305}.
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DR EMBL; AF083977; AAF01127.1; -; Genomic_DNA.
DR RefSeq; NP_050653.1; NC_000929.1.
DR PDB; 5YVQ; X-ray; 2.10 A; A=1-504.
DR PDBsum; 5YVQ; -.
DR SMR; Q9T1V0; -.
DR GeneID; 2636293; -.
DR KEGG; vg:2636293; -.
DR Proteomes; UP000002611; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0098024; C:virus tail, fiber; IEA:UniProtKB-KW.
DR GO; GO:0098671; P:adhesion receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0098678; P:viral tropism switching; IEA:UniProtKB-KW.
DR InterPro; IPR005068; Phage_lambda_Stf-r2.
DR Pfam; PF03406; Phage_fiber_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Host cytoplasm; Host-virus interaction; Late protein;
KW Reference proteome; Viral attachment to host adhesion receptor;
KW Viral attachment to host cell; Viral receptor tropism switching;
KW Viral tail fiber protein; Viral tail protein; Virion;
KW Virus entry into host cell.
FT CHAIN 1..504
FT /note="Tail fiber protein S"
FT /id="PRO_0000077693"
FT HELIX 139..148
FT /evidence="ECO:0007829|PDB:5YVQ"
FT HELIX 153..155
FT /evidence="ECO:0007829|PDB:5YVQ"
FT TURN 156..159
FT /evidence="ECO:0007829|PDB:5YVQ"
FT HELIX 163..170
FT /evidence="ECO:0007829|PDB:5YVQ"
FT HELIX 173..180
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 202..206
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 209..216
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 226..235
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 239..245
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 248..256
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 259..264
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 276..278
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 280..282
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 285..287
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 289..293
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 295..302
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 317..321
FT /evidence="ECO:0007829|PDB:5YVQ"
FT TURN 322..324
FT /evidence="ECO:0007829|PDB:5YVQ"
FT HELIX 353..357
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 373..380
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 382..392
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 395..402
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 407..409
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 411..417
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 422..426
FT /evidence="ECO:0007829|PDB:5YVQ"
FT HELIX 434..437
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 440..446
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 465..471
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 484..494
FT /evidence="ECO:0007829|PDB:5YVQ"
FT STRAND 497..500
FT /evidence="ECO:0007829|PDB:5YVQ"
SQ SEQUENCE 504 AA; 55361 MW; C564B6746F53993B CRC64;
MFYIDNDSGV TVMPPVSAQR SAIVRWFSEG DGNNVITWPG MDWFNIVQAE LLNTLEEAGI
QPDKTKLNQL ALSIKAIMSN NALLIKNNLS EIKTAGASAQ RTARENLDIY DASLNKKGLV
QLTSATDSPS ETLAATAKAV KIAMDNANAR LAKDRNGADI PNKPLFIQNL GLQETVNRAR
NAVQKNGDTL SGGLTFENDS ILAWIRNTDW AKIGFKNDAD SDTDSYMWFE TGDNGNEYFK
WRSKQSTTTK DLMNLKWDAL SVLVNAIVNG EVISKSANGL RIAYGNYGFF IRNDGSNTYF
MLTNSGDNMG TYNGLRPLWI NNATGAVSMG RGLNVSGDTL SDRFAINSSN GMWIQMRDNN
AIFGKNIVNT DSAQALLRQN HADRKFMIGG LGNKQFGIYM INNSRTANGT DGQAYMDNNG
NWLCGAQVIP GNYANFDSRY VRDVRLGTQS LTGGLSRDYK APSGHVITGF HTNGDWEMQG
GDDKVYIRPV QKNINGTWYN VASA
