S20A1_FELCA
ID S20A1_FELCA Reviewed; 681 AA.
AC O97596; Q6R4N7;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Sodium-dependent phosphate transporter 1;
DE AltName: Full=Feline leukemia virus subtype-B receptor;
DE AltName: Full=Phosphate transporter 1;
DE Short=PiT-1;
DE AltName: Full=Solute carrier family 20 member 1;
GN Name=Slc20a1; Synonyms=Pit1;
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lymphoma;
RX PubMed=9878855; DOI=10.1016/s0167-4781(98)00241-3;
RA Rudra-Ganguly N., Ghosh A.K., Roy-Burman P.;
RT "Retrovirus receptor PiT-1 of the Felis catus.";
RL Biochim. Biophys. Acta 1443:407-413(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Occipital cortex;
RA Lochrie M.A.;
RT "Feline homolog of gibbon ape leukemia virus receptor (GALV1) is a receptor
RT for feline leukemia virus (subtype-B).";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sodium-phosphate symporter which plays a fundamental
CC housekeeping role in phosphate transport, such as absorbing phosphate
CC from interstitial fluid for normal cellular functions such as cellular
CC metabolism, signal transduction, and nucleic acid and lipid synthesis.
CC May play a role in extracellular matrix and cartilage calcification as
CC well as in vascular calcification.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- MISCELLANEOUS: Ectopic expression of feline SLC20A1 in guinea pig cells
CC which are not permissive to Feline leukemia virus subgroup B (FeLV-B)
CC confers susceptibility to FeLV-B infection.
CC -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC 2.A.20) family. {ECO:0000305}.
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DR EMBL; AF074085; AAD08995.1; -; mRNA.
DR EMBL; AY514486; AAS00090.1; -; mRNA.
DR RefSeq; NP_001009840.1; NM_001009840.1.
DR RefSeq; XP_011279434.1; XM_011281132.2.
DR RefSeq; XP_019681729.1; XM_019826170.1.
DR AlphaFoldDB; O97596; -.
DR SMR; O97596; -.
DR STRING; 9685.ENSFCAP00000007501; -.
DR GeneID; 493789; -.
DR KEGG; fca:493789; -.
DR CTD; 6574; -.
DR eggNOG; KOG2493; Eukaryota.
DR HOGENOM; CLU_015355_3_1_1; -.
DR InParanoid; O97596; -.
DR OMA; KYDESGV; -.
DR OrthoDB; 712010at2759; -.
DR Proteomes; UP000011712; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR001204; Phos_transporter.
DR PANTHER; PTHR11101; PTHR11101; 1.
DR Pfam; PF01384; PHO4; 1.
PE 2: Evidence at transcript level;
KW Membrane; Phosphate transport; Phosphoprotein; Receptor;
KW Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..681
FT /note="Sodium-dependent phosphate transporter 1"
FT /id="PRO_0000080770"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 515..535
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 562..582
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 604..624
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 654..674
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 269..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..562
FT /note="A"
FT /evidence="ECO:0000250"
FT COMPBIAS 269..294
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 269
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WUM9"
FT MOD_RES 273
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WUM9"
FT CONFLICT 127
FT /note="L -> F (in Ref. 2; AAS00090)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 681 AA; 74020 MW; 243238766D6A984B CRC64;
MAFTGATLTT STIAATAASG PLMDYLWMLI LGFIIAFVLA FSVGANDVAN SFGTAVGSGV
VTLKQACILA SIFETVGSVL LGAKVSETIR KGLIDVEMYN TTQQLLMAGS VSAMFGSAVW
QLVASFLKLP ISGTHCIVGA TIGFSLVAKG QEGVKWSELI KIVMSWFISP LLSGIMSGIL
FFLVRAFILR KTDPVPNGLR ALPVFYACTV GINLFSIMYT GAPLLGFDKL PLWGTILISV
GCAVFCALIV WFFVCPRMKR KIEREIKSSP SESPLMEKKN SLKEDHEETK LSVSDIETRS
PVSEVGSATV PLRAVVEERT VSFKLGDLEE APERERLPSV DLKEETSIDS AMNGAVQLPN
GNLVQFNQAV SNQMNSSGHY QYHTVHKDSG LYKELLHKLH LAKVGDCMGD SGDKPLRRNN
SYTSYTMAIC GMPLDSFRAK EGEQKGEEME KLTWPNAESK KRIRMDSYTS YCNAVSDIHS
ASEMDMSVKA EMGLGDRKGS SSSLEEWYDQ DKPEVSLLFQ FLQILTACFG SFAHGGNDVS
NAIGPLVALY LVYDTGDVSS KVATPIWLLL YGGVGICIGL WVWGRRVIQT MGKDLTPITP
SSGFSIELAS ALTVVIASNI GLPISTTHCK VGSVVSVGWL RSKKAVDWRL FRNIFMAWFV
TVPISGVISA AIMAVFKYVI L
