ID   S20A1_PONAB             Reviewed;         679 AA.
AC   Q5R9L5; Q5R7T0;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Sodium-dependent phosphate transporter 1;
DE   AltName: Full=Solute carrier family 20 member 1;
GN   Name=SLC20A1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sodium-phosphate symporter which plays a fundamental
CC       housekeeping role in phosphate transport, such as absorbing phosphate
CC       from interstitial fluid for normal cellular functions such as cellular
CC       metabolism, signal transduction, and nucleic acid and lipid synthesis.
CC       May play a role in extracellular matrix and cartilage calcification as
CC       well as in vascular calcification (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC       2.A.20) family. {ECO:0000305}.
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DR   EMBL; CR859372; CAH91545.1; -; mRNA.
DR   EMBL; CR860029; CAH92180.1; -; mRNA.
DR   RefSeq; NP_001126276.1; NM_001132804.1.
DR   AlphaFoldDB; Q5R9L5; -.
DR   SMR; Q5R9L5; -.
DR   STRING; 9601.ENSPPYP00000013569; -.
DR   GeneID; 100173250; -.
DR   KEGG; pon:100173250; -.
DR   CTD; 6574; -.
DR   eggNOG; KOG2493; Eukaryota.
DR   InParanoid; Q5R9L5; -.
DR   OrthoDB; 712010at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001204; Phos_transporter.
DR   PANTHER; PTHR11101; PTHR11101; 1.
DR   Pfam; PF01384; PHO4; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Phosphate transport; Phosphoprotein; Receptor;
KW   Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..679
FT                   /note="Sodium-dependent phosphate transporter 1"
FT                   /id="PRO_0000080773"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        511..531
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        558..578
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        600..620
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        650..670
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          268..288
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          550..558
FT                   /note="A"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         265
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WUM9"
FT   MOD_RES         269
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WUM9"
FT   CONFLICT        189
FT                   /note="D -> N (in Ref. 1; CAH92180)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        397
FT                   /note="L -> P (in Ref. 1; CAH92180)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   679 AA;  73687 MW;  E6E1F0F6A5071CCC CRC64;
     MAALITSTTA ATAASGPLVD YLWMLILGFI IAFVLAFSVG ANDVANSFGT AVGSGVVTLK
     QACILASIFE TVGSVLLGAK VSETIRKGLI DVEMYNSTQG LLMAGSVSAM FGSAVWQLVA
     SFLKLPISGT HCIVGATIGF SLVAKGQEGV KWSELIKIVM SWFVSPLLSG IMSGILFFLV
     RAFILHKADP VPNGLRALPV FYACTVGINL FSIMYTGAPL LGFDKLPLWG TILISVGCAV
     FCALIVWFFV CPRMKRKIER EIKCSPSESP LMEKKNSLKE DHEETKLSVS DIENRNPVSE
     VGPATVPLQA VVEERTVSFK LGDLEEAPER ERLPSVDLKE ETSIDSTVNG AVQLPNGNLV
     QFSQAVSNQI NSSGHYQYHT VHKDSGLYKE LLHKLHLAKV GDCMGDSGDK PLRRNNSYTS
     YTMAICGMPL DSFRAKEGEQ KGEEVEKLTW PNADSKKRIR MDSYTSYCNA VSDLHSASEI
     DMSVKAEMGL GDRKGSNGSL EEWYDQDKPE VSLLFQFLQI LTACFGSFAH GGNDVSNAIG
     PLVALYLVYD TGDVSSKVAT PIWLLLYGGV GICIGLWVWG RRVIQTMGKD LTPITPSSGF
     SIELASALTV VIASNIGLPI STTHCKVGSV VSVGWLRSKK AVDWRLFRNI FMAWFVTVPI
     SGVISAAIMA IFRYVILRM