S20A1_RAT
ID S20A1_RAT Reviewed; 681 AA.
AC Q9JJP0;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Sodium-dependent phosphate transporter 1;
DE AltName: Full=Phosphate transporter 1;
DE Short=PiT-1;
DE AltName: Full=RPHO-1;
DE AltName: Full=Solute carrier family 20 member 1;
GN Name=Slc20a1; Synonyms=Pit1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RC TISSUE=Parathyroid;
RX PubMed=9528951; DOI=10.1210/endo.139.4.5925;
RA Tatsumi S., Segawa H., Morita K., Haga H., Kouda T., Yamamoto H., Inoue Y.,
RA Nii T., Katai K., Taketani Y., Miyamoto K., Takeda E.;
RT "Molecular cloning and hormonal regulation of PiT-1, a sodium-dependent
RT phosphate cotransporter from rat parathyroid glands.";
RL Endocrinology 139:1692-1699(1998).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Sodium-phosphate symporter which plays a fundamental
CC housekeeping role in phosphate transport, such as absorbing phosphate
CC from interstitial fluid for normal cellular functions such as cellular
CC metabolism, signal transduction, and nucleic acid and lipid synthesis.
CC May play a role in extracellular matrix and cartilage calcification as
CC well as in vascular calcification. {ECO:0000269|PubMed:9528951}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC -!- INDUCTION: By 1,25-dihydroxyvitamin D3 and phosphate deprivation.
CC {ECO:0000269|PubMed:9528951}.
CC -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC 2.A.20) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB000489; BAB07789.1; -; mRNA.
DR RefSeq; NP_112410.1; NM_031148.1.
DR RefSeq; XP_006235053.1; XM_006234991.3.
DR AlphaFoldDB; Q9JJP0; -.
DR SMR; Q9JJP0; -.
DR BioGRID; 249684; 1.
DR STRING; 10116.ENSRNOP00000025294; -.
DR iPTMnet; Q9JJP0; -.
DR PhosphoSitePlus; Q9JJP0; -.
DR PaxDb; Q9JJP0; -.
DR PRIDE; Q9JJP0; -.
DR Ensembl; ENSRNOT00000025294; ENSRNOP00000025294; ENSRNOG00000018567.
DR GeneID; 81826; -.
DR KEGG; rno:81826; -.
DR UCSC; RGD:621079; rat.
DR CTD; 6574; -.
DR RGD; 621079; Slc20a1.
DR eggNOG; KOG2493; Eukaryota.
DR GeneTree; ENSGT00390000014879; -.
DR HOGENOM; CLU_015355_3_1_1; -.
DR InParanoid; Q9JJP0; -.
DR OMA; MQAFCIA; -.
DR OrthoDB; 712010at2759; -.
DR PhylomeDB; Q9JJP0; -.
DR TreeFam; TF314426; -.
DR Reactome; R-RNO-427652; Sodium-coupled phosphate cotransporters.
DR PRO; PR:Q9JJP0; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000018567; Expressed in cerebellum and 20 other tissues.
DR Genevisible; Q9JJP0; RN.
DR GO; GO:0016021; C:integral component of membrane; IDA:RGD.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0005316; F:high-affinity inorganic phosphate:sodium symporter activity; IDA:RGD.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0031214; P:biomineral tissue development; ISO:RGD.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006817; P:phosphate ion transport; IDA:RGD.
DR GO; GO:0006814; P:sodium ion transport; IDA:RGD.
DR InterPro; IPR001204; Phos_transporter.
DR PANTHER; PTHR11101; PTHR11101; 1.
DR Pfam; PF01384; PHO4; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphate transport; Phosphoprotein; Receptor;
KW Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..681
FT /note="Sodium-dependent phosphate transporter 1"
FT /id="PRO_0000080774"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 513..533
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 561..581
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 602..622
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 652..672
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 266..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..293
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 269
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WUM9"
FT MOD_RES 273
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 681 AA; 74187 MW; 5CB6C81CBF4F1292 CRC64;
MASTLAPITS TLAAVTASAP PKYDNLWMLI LGFIIAFVLA FSVGANDVAN SFGTAVGSGV
VTLKQACILA SIFETVGSAL LGAKVSETIR KGLIDVEKYN ATQDLLMAGS VSAMFGSAVW
QLVASFLKLP ISGTHCIVGA TIGFSLVAKG QEGIKWSELI KIVMSWFVSP LLSGIMSGIL
FFLVRAFILR KADPVPNGLR ALPIFYACTI GINLFSIMYT GAPLLGFDKL PLWGTILISV
GCAVFCALIV WFFVCPRMKR KIEREVKSSP SESPLMEKKN NLKDHEETKM APGDVENRNP
VSEVVCATGP LRAVVEERTV SFKLGDLEEA PERERLPMDL KEETNIDGTI NGAVQLPNGN
LVQFSQTVSN QINSSGHYQY HTVHKDSGLY KELLHKLHLA KVGDCMGDSG DKPLRRNNSY
TSYTMAICGM PLDSFRAKEG EQKGDEMETL TWPNADTKKR IRMDSYTSYC NAVSDLHSES
EMDMSVKAEM GLGDRKGSSG SLEEWYDQDK PEVSLLFQFL QILTACFGSF AHGGNDVSNA
IGPLVALYLV YETRDVTTKE ATPIWLLLYG GVGICMGLWV WGRRVIQTMG KDLTPITPSS
GFSIELASAF TVVVASNIGL PISTTHCKVG SVVSVGWLRS KKAVDWRLFR NIFMAWFVTV
PISGVISAAI MAVFKHIILP V
