ID   S20A1_XENTR             Reviewed;         685 AA.
AC   Q5BL44;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Sodium-dependent phosphate transporter 1;
DE   AltName: Full=Solute carrier family 20 member 1;
GN   Name=slc20a1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sodium-phosphate symporter which plays a fundamental
CC       housekeeping role in phosphate transport. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC       2.A.20) family. {ECO:0000305}.
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DR   EMBL; BC090608; AAH90608.1; -; mRNA.
DR   RefSeq; NP_001025568.1; NM_001030397.1.
DR   RefSeq; XP_012814579.1; XM_012959125.2.
DR   AlphaFoldDB; Q5BL44; -.
DR   SMR; Q5BL44; -.
DR   STRING; 8364.ENSXETP00000041138; -.
DR   TCDB; 2.A.20.2.6; the inorganic phosphate transporter (pit) family.
DR   PaxDb; Q5BL44; -.
DR   DNASU; 594956; -.
DR   Ensembl; ENSXETT00000041138; ENSXETP00000041138; ENSXETG00000018957.
DR   GeneID; 594956; -.
DR   KEGG; xtr:594956; -.
DR   CTD; 6574; -.
DR   Xenbase; XB-GENE-482940; slc20a1.
DR   eggNOG; KOG2493; Eukaryota.
DR   HOGENOM; CLU_015355_3_1_1; -.
DR   InParanoid; Q5BL44; -.
DR   OMA; KYDESGV; -.
DR   OrthoDB; 712010at2759; -.
DR   PhylomeDB; Q5BL44; -.
DR   TreeFam; TF314426; -.
DR   Reactome; R-XTR-427652; Sodium-coupled phosphate cotransporters.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000018957; Expressed in mesonephros and 17 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR001204; Phos_transporter.
DR   PANTHER; PTHR11101; PTHR11101; 1.
DR   Pfam; PF01384; PHO4; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Phosphate transport; Reference proteome; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..685
FT                   /note="Sodium-dependent phosphate transporter 1"
FT                   /id="PRO_0000080779"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        517..537
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        565..585
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        606..626
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        656..676
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          482..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        493..513
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   685 AA;  74860 MW;  C6AE216BFAA6C0BC CRC64;
     MESTTAFSEV TSALGIENVK IMEPFLWMLV LGFVIAFVLA FSVGANDVAN SFGTAVGSGV
     VTLRQACILA SIFETVGSVL LGAKVSETIR KGLIDVNTYN TTQELLMAGS ISAMFGSAVW
     QLAASFLKLP ISGTHCIVGA TIGFSLVAKG QQAIQWYELL RIVLSWFISP LLSGIMSALL
     FYFVRMFILR KADPVPNGLR ALPIFYACTI GVNLFSIMYS GAPLLGFDKI PLWGIILISV
     GCAVLCALVV WFFVCPRMKR KIECEFKSSP SESPLMDKKN RELRCPILKP DPEDIKLPVD
     GGIVAEVKVP ILDMVSVSRT EERTVTFKMG DCDDAVEKEK LNSMETNIDQ PMNGSVQLPN
     GNHVQFSQTV SNQMNSSGQY QYHTVHKDSG LYKDLLHKLH LAKVGDCMGD SGDKPLRRNN
     SYTSYTMAIC GMPLDSLRNR DAEARPDEAE KFTVHGADGK KRIRMDSYTS YCNAVADPQM
     DVEAEEQEEG SIEDVATDRK SSSSSLEERH DQDKPEVSLL FQFLQILTAC FGSFAHGGND
     VSNAIGPLVA LYLVYESGDV TTKAATPIWL LLYGGVGICI GLWVWGRRVI QTMGKDLTPI
     TPSSGFSIEL ASALTVVIAS NVGLPISTTH CKVGSVVSVG WLRSKKAVDW RLFRNIFLAW
     FVTVPISGLI SAAIMAVFKY AILKK