S20A2_BOVIN
ID S20A2_BOVIN Reviewed; 645 AA.
AC A1A4I1;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Sodium-dependent phosphate transporter 2;
DE AltName: Full=Phosphate transporter 2;
DE Short=PiT-2;
DE AltName: Full=Solute carrier family 20 member 2;
GN Name=SLC20A2; Synonyms=PIT2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sodium-phosphate symporter which seems to play a fundamental
CC housekeeping role in phosphate transport by absorbing phosphate from
CC interstitial fluid for normal cellular functions such as cellular
CC metabolism, signal transduction, and nucleic acid and lipid synthesis.
CC In vitro, sodium-dependent phosphate uptake is not significantly
CC affected by acidic and alkaline conditions, however sodium-independent
CC phosphate uptake occurs at acidic conditions. May play a role in
CC extracellular matrix, cartilage calcification and vascular
CC calcification. Functions as a retroviral receptor (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC 2.A.20) family. {ECO:0000305}.
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DR EMBL; BC126506; AAI26507.1; -; mRNA.
DR RefSeq; NP_001073749.1; NM_001080280.1.
DR AlphaFoldDB; A1A4I1; -.
DR SMR; A1A4I1; -.
DR STRING; 9913.ENSBTAP00000056283; -.
DR iPTMnet; A1A4I1; -.
DR GeneID; 518905; -.
DR KEGG; bta:518905; -.
DR CTD; 6575; -.
DR eggNOG; KOG2493; Eukaryota.
DR InParanoid; A1A4I1; -.
DR OrthoDB; 712010at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR001204; Phos_transporter.
DR PANTHER; PTHR11101; PTHR11101; 1.
DR Pfam; PF01384; PHO4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Host-virus interaction; Ion transport;
KW Membrane; Phosphate transport; Phosphoprotein; Receptor;
KW Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..645
FT /note="Sodium-dependent phosphate transporter 2"
FT /id="PRO_0000341265"
FT TOPO_DOM 1..5
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 27..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..86
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..109
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..142
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..190
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..213
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..475
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 476..496
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 497..523
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 524..544
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 545..564
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 565..579
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 580..586
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 587..602
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 603..614
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 615..635
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 636..645
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 275..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 253
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q63488"
FT MOD_RES 256
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q08357"
FT MOD_RES 259
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q08357"
FT MOD_RES 268
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q08357"
FT MOD_RES 316
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q08357"
FT MOD_RES 379
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q08357"
FT CARBOHYD 81
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 645 AA; 69610 MW; 83D7768CCEF46AB5 CRC64;
MAMDEYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL ASIFETTGSV
LLGAKVGETI RKGIIDVNLY NNTVETLMAG EVSAMVGSAV WQLIASFLRF PISGTHCIVG
ATIGFSLVAI GTQGVQWMEL VKIVASWFIS PLLSGFMSGV LFVLIRMFIL KKEDPVPNGL
RALPVFYAAT IAINVFSIMY TGAPVMGLVL PMWAIALISF GVALLFALFV WLFVCPWMRR
KITGKLQKEC ALSRASDESL NKIQEVESPV FKELPGAKAH DDSTVPLTGS AADPSGTSES
MSGGHHPRAP YGRALSMTHG TTKSPVSNGT FGFDGTARAD GHVYHTVHKD SGLYKDLLHR
IRDERPADGA PRQLRRNNSY TCYTAAICGL PGLATRRGDT PAPEDSEKLV ADAVAYSRRR
LRYDSYSSYC NAVAEAEIEA EEGGVEVRLA PPLAEPEPPR DDPADEEKEE KDSPEVHLLF
HFLQVLTACF GSFAHGGNDV SNAIGPLVAL WLIYEQGAVL QEAATPVWLL FYGGVGICTG
LWVWGRRVIQ TMGKDLTPIT PSSGFTIELA SAFTVVIASN IGLPVSTTHC KVGSVVAVGW
IRSRKAVDWR LFRNIFVAWF VTVPVAGLFS AAIMALLIHG ILPFV
