S20A2_FELCA
ID S20A2_FELCA Reviewed; 653 AA.
AC Q95L97;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Sodium-dependent phosphate transporter 2;
DE AltName: Full=Phosphate transporter 2;
DE Short=FePit2;
DE Short=PiT-2;
DE AltName: Full=Solute carrier family 20 member 2;
GN Name=SLC20A2; Synonyms=PIT2;
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION AS RETROVIRAL RECEPTOR.
RX PubMed=11602698; DOI=10.1128/jvi.75.22.10563-10572.2001;
RA Anderson M.M., Lauring A.S., Robertson S., Dirks C., Overbaugh J.;
RT "Feline Pit2 functions as a receptor for subgroup B feline leukemia
RT viruses.";
RL J. Virol. 75:10563-10572(2001).
CC -!- FUNCTION: Sodium-phosphate symporter which seems to play a fundamental
CC housekeeping role in phosphate transport by absorbing phosphate from
CC interstitial fluid for normal cellular functions such as cellular
CC metabolism, signal transduction, and nucleic acid and lipid synthesis.
CC In vitro, sodium-dependent phosphate uptake is not significantly
CC affected by acidic and alkaline conditions, however sodium-independent
CC phosphate uptake occurs at acidic conditions. May play a role in
CC extracellular matrix, cartilage calcification and vascular
CC calcification (By similarity). Functions as a retroviral receptor for
CC feline leukemia virus subgroup B (FeLV-B). {ECO:0000250,
CC ECO:0000269|PubMed:11602698}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC 2.A.20) family. {ECO:0000305}.
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DR EMBL; AF394194; AAK73822.1; -; mRNA.
DR RefSeq; NP_001009839.1; NM_001009839.1.
DR AlphaFoldDB; Q95L97; -.
DR SMR; Q95L97; -.
DR STRING; 9685.ENSFCAP00000009354; -.
DR GeneID; 493788; -.
DR KEGG; fca:493788; -.
DR CTD; 6575; -.
DR eggNOG; KOG2493; Eukaryota.
DR InParanoid; Q95L97; -.
DR TreeFam; TF314426; -.
DR Proteomes; UP000011712; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0001618; F:virus receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR001204; Phos_transporter.
DR PANTHER; PTHR11101; PTHR11101; 1.
DR Pfam; PF01384; PHO4; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Host cell receptor for virus entry;
KW Host-virus interaction; Ion transport; Membrane; Phosphate transport;
KW Phosphoprotein; Receptor; Reference proteome; Sodium; Sodium transport;
KW Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..653
FT /note="Sodium-dependent phosphate transporter 2"
FT /id="PRO_0000341267"
FT TOPO_DOM 1..5
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 27..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..86
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..109
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..142
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..190
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..213
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..483
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 505..531
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 532..552
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 553..572
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 573..587
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 588..594
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 595..610
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 611..622
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 623..643
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 644..653
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 275..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 253
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q63488"
FT MOD_RES 256
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q08357"
FT MOD_RES 259
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q08357"
FT MOD_RES 268
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q08357"
FT MOD_RES 316
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q08357"
FT MOD_RES 385
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q08357"
FT CARBOHYD 81
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 653 AA; 70492 MW; 386C5D68D3B6C006 CRC64;
MAIDGYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL ASIFETTGSV
LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV WQLIASFLRL PISGTHCIVG
STIGFSLVAI GTQGVQWMEL VKIVASWFIS PLLSGFMSGV LFILIRIFIL KKEDPVPNGL
RALPVFYAAT IAINVFSIMY TGAPVLGLVL PIWAIALISF GVALLFALFV WLFVCPWMRR
KIAGKLQKEA ALSRVSDESL SKIQEVESPV FKELPGAKAN DDSTVPLTGS AGEPSGTSEG
TSVGNHPRAS YGRALSMTHG SAKSPVSNGT FGFDGHTRSD GHVYHTVHKD SGLYKDLLHR
IHSDRGPEER PAQENNYRFL RRNNSYTCYT AAICGMPVHS TFKAADSSSA PEDSEKLVGD
AVSYSKKRLR YDSYSSYCNA VAEAEIEADE GGVEMKLASE LTDPDQPRDD PAEEEKEEKD
TAEVHLLFHF LQVLTACFGS FAHGGNDVSN AIGPLVALWL IYEQGAVLQE AVTPVWLLFY
GGVGICTGLW VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVIASNVG LPVSTTHCKV
GSVVAVGWIR SRKAVDWRLF RNIFVAWFVT VPVAGLFSAA IMALLMYGIL PYV
