S20A2_XENLA
ID S20A2_XENLA Reviewed; 653 AA.
AC Q5XHF9;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Sodium-dependent phosphate transporter 2;
DE AltName: Full=Solute carrier family 20 member 2;
GN Name=slc20a2;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sodium-phosphate symporter which seems to play a fundamental
CC housekeeping role in phosphate transport by absorbing phosphate from
CC interstitial fluid for normal cellular functions such as cellular
CC metabolism, signal transduction, and nucleic acid and lipid synthesis.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC 2.A.20) family. {ECO:0000305}.
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DR EMBL; BC084098; AAH84098.1; -; mRNA.
DR RefSeq; NP_001088186.1; NM_001094717.1.
DR AlphaFoldDB; Q5XHF9; -.
DR SMR; Q5XHF9; -.
DR MaxQB; Q5XHF9; -.
DR DNASU; 495011; -.
DR GeneID; 495011; -.
DR KEGG; xla:495011; -.
DR CTD; 495011; -.
DR Xenbase; XB-GENE-1015062; slc20a2.L.
DR OrthoDB; 712010at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 495011; Expressed in heart and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR001204; Phos_transporter.
DR PANTHER; PTHR11101; PTHR11101; 1.
DR Pfam; PF01384; PHO4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Ion transport; Membrane; Phosphate transport;
KW Receptor; Reference proteome; Sodium; Sodium transport; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..653
FT /note="Sodium-dependent phosphate transporter 2"
FT /id="PRO_0000341271"
FT TOPO_DOM 1..5
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 27..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..86
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..109
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..142
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..187
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..217
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 239..483
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 505..532
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 533..553
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 554..572
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 573..587
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 588..594
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 595..610
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 611..622
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 623..643
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 644..653
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 275..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 81
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 653 AA; 70594 MW; 5FDDBC10739EFB65 CRC64;
MVLDEYMWMV IVGFIIAFVL AFSVGANDVA NSFGTAVGSG VVTLRQACIL ASIFETIGSV
LLGAKVGETI RKGIIDVNLY NNTVDLLMAG EVSAMVGSAV WQLIASFLKL PVSGTHCIVG
ATIGFSLVAV GAHSVQWMQL VKIVASWFIS PLLSGLMSGA LFLMIKFFIL NKEDPVPNGL
KALPVFYAAT IGINVFSILF TGAPLLGLQT FPVWATALLS VGIAIVFALV VWFFVCPWMK
KKIASRLKKE GALSRISEES LDKIQDEDTS VFKELPGAKG NDESVLPLTS SSPDAAVSSE
SVSNGNTRVP YGRAASMTNG SIRSPFSNGT FNFDGHTVKS DAHVYHTVHK DSGLYKDLLH
NIHLDRVKID RSAPENNYRI LRRNNSYTCY TAAICGVPVH STFKSSDIAM PEDSEKLVGD
TVSFSKKRLR YDSYSSYCNA VAEAEIEAEE GGVEMKLAAE LADPNPPQDD SLEEDKEEKD
KSQVHLLFHF LQILTACFGS FAHGGNDVSN AIGPLVALWL IYQQGGVMQE ASTPVWLLLY
GGVGICAGLW VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVVASNIG LPISTTHCKV
GSVVAVGWIR SRKAVDWRLF RNIFLAWFVT VPVAGLFSAG VMAILQYGIL PYV
