S20A2_XENTR
ID S20A2_XENTR Reviewed; 653 AA.
AC Q28E01;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Sodium-dependent phosphate transporter 2;
DE AltName: Full=Solute carrier family 20 member 2;
GN Name=slc20a2; ORFNames=TEgg117l18.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sodium-phosphate symporter which seems to play a fundamental
CC housekeeping role in phosphate transport by absorbing phosphate from
CC interstitial fluid for normal cellular functions such as cellular
CC metabolism, signal transduction, and nucleic acid and lipid synthesis.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC 2.A.20) family. {ECO:0000305}.
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DR EMBL; CR848513; CAJ82318.1; -; mRNA.
DR RefSeq; NP_001016904.1; NM_001016904.2.
DR RefSeq; XP_012818450.1; XM_012962996.2.
DR RefSeq; XP_012818454.1; XM_012963000.2.
DR AlphaFoldDB; Q28E01; -.
DR SMR; Q28E01; -.
DR PaxDb; Q28E01; -.
DR GeneID; 549658; -.
DR KEGG; xtr:549658; -.
DR CTD; 6575; -.
DR Xenbase; XB-GENE-1015057; slc20a2.
DR eggNOG; KOG2493; Eukaryota.
DR HOGENOM; CLU_015355_3_1_1; -.
DR InParanoid; Q28E01; -.
DR OMA; IVYDNRV; -.
DR OrthoDB; 712010at2759; -.
DR PhylomeDB; Q28E01; -.
DR TreeFam; TF314426; -.
DR Reactome; R-XTR-427652; Sodium-coupled phosphate cotransporters.
DR Proteomes; UP000008143; Chromosome 1.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000009532; Expressed in skeletal muscle tissue and 13 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR001204; Phos_transporter.
DR PANTHER; PTHR11101; PTHR11101; 1.
DR Pfam; PF01384; PHO4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Ion transport; Membrane; Phosphate transport;
KW Receptor; Reference proteome; Sodium; Sodium transport; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..653
FT /note="Sodium-dependent phosphate transporter 2"
FT /id="PRO_0000341272"
FT TOPO_DOM 1
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 23..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..86
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..109
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..142
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..187
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..217
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 239..483
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 505..532
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 533..553
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 554..572
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 573..587
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 588..594
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 595..610
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 611..622
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 623..643
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 644..653
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 81
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 653 AA; 70621 MW; C16BB5C2A5A4BB79 CRC64;
MVLVEYLWMV IVGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL ASIFETTGSV
LLGAKVGETI RKGIIDVNLY NNTVDLLMAG EVSAMVGSAV WQLIASFLRL PISGTHCIVG
ATIGFSLVAI GTHGVQWMQL VKIVASWFIS PLLSGLMSGA LFLMIKFFIL KKEDPVPNGL
KALPVFYAAT IGINVFSILY TGAPLLGLES FPVWATALLS IGIAIIFALI VWFFVCPWMK
KKIASRLKKE GALSRISEES LDKIQDEETS VFKELPGAKG NDESALPLTS SSTDAAVASD
SVSNGNTRVP YGRAASMTNG SIRSPISNGT FNFDGHTVKS DVHVYHTVHK DSGLYKDLLH
NIHLDRVKTD RPAPENNYRV LRRNNSYTCY TAAICGVPVH STFKSSDVAM PEDSEKLVGD
TVSYSKKRVR YDSYSSYCNA VAEAEIEAEE GGVEMKLATD LADPNPPQDD SLEEDKEEKD
KSEVHLLFHF LQILTACFGS FAHGGNDVSN AIGPLVALWL IYEQGGVMQE ASTPVWLLLY
GGVGICAGLW VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVVASNIG LPISTTHCKV
GSVVAVGWIR SRKAVDWRLF RNIFLAWFVT VPVAGLFSAG VMAILQYGIL PYV
