ID   S20AA_DANRE             Reviewed;         652 AA.
AC   Q6NV12;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Sodium-dependent phosphate transporter 1-A;
DE   AltName: Full=Solute carrier family 20 member 1-A;
GN   Name=slc20a1a; ORFNames=zgc:85672;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sodium-phosphate symporter which plays a fundamental
CC       housekeeping role in phosphate transport. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC       2.A.20) family. {ECO:0000305}.
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DR   EMBL; BC068354; AAH68354.1; -; mRNA.
DR   RefSeq; NP_998344.1; NM_213179.1.
DR   AlphaFoldDB; Q6NV12; -.
DR   SMR; Q6NV12; -.
DR   STRING; 7955.ENSDARP00000005218; -.
DR   PaxDb; Q6NV12; -.
DR   GeneID; 406458; -.
DR   KEGG; dre:406458; -.
DR   CTD; 406458; -.
DR   ZFIN; ZDB-GENE-040426-2217; slc20a1a.
DR   eggNOG; KOG2493; Eukaryota.
DR   InParanoid; Q6NV12; -.
DR   OrthoDB; 712010at2759; -.
DR   PhylomeDB; Q6NV12; -.
DR   PRO; PR:Q6NV12; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR001204; Phos_transporter.
DR   PANTHER; PTHR11101; PTHR11101; 1.
DR   Pfam; PF01384; PHO4; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Phosphate transport; Reference proteome; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..652
FT                   /note="Sodium-dependent phosphate transporter 1-A"
FT                   /id="PRO_0000080776"
FT   TOPO_DOM        1..25
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..66
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        88..104
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        126..162
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        184..201
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        223..234
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        256..482
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        483..503
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        504..531
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        532..552
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        553..571
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        572..592
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        593..621
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        622..642
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        643..652
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          278..308
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   652 AA;  69935 MW;  FDE4C660CD83BDAE CRC64;
     MESTTLASLA AVSVLAAGAQ TDMSDVLWLL ILGFVIAFIL AFSVGANDVA NSFGTAVGSG
     VVTLRQACIL ATIFETVGAM LLGAKVSETI RSGIIDVHMY NGSEAVLMAG SISAMFGSAV
     WQLAASFLKL PISGTHCIVG ATIGFSMVAR GHQGVKWLEL LRIVASWFLS PLLSGIMSAV
     LFYFVRKFIL NKDDPVPNGL RALPVFYAVT MGINLFSIMF TGAPMLGFDR IPWWGTLLIS
     LGCAILTALV VWFIVCPRLK KKMQSKCLGP NIADTSGTQL VEKKPSSNGL MDHHPGPPRN
     YSPVPQTPPA DSNKVAFDIG GSAETDLDKK EFDTKDQDCT HALNGSGGIV IPDLSGNQFH
     TVHKDSGIYK DLLHKLHLAK VGECIGEPVE KPIRRNNSYT SYTMAIYGIH GSLKDGEGGS
     RTGLDGEKRR SRYDSYNSYC TAVADGEAAL EDAALAVGME DEALREDVLE EDIDELEIDK
     PEVSTLFQFL QILTACFGSF AHGGNDVSNA IGPLVALWLI YDSASVAPSA PTPIWLLLYG
     GVGICTGLWI WGRRVIQTMG KDLTPITPSS GFSIELASAI TVVVASNIGL PVSTTHCKVG
     SVVSVGWLRS RKAVDWHLFR NIFIAWFVTV PISGLISAAI MALFYYVILP LT