ID   S20AA_XENLA             Reviewed;         685 AA.
AC   Q68F35;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Sodium-dependent phosphate transporter 1-A;
DE   AltName: Full=Solute carrier family 20 member 1-A;
GN   Name=slc20a1-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sodium-phosphate symporter which plays a fundamental
CC       housekeeping role in phosphate transport. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC       2.A.20) family. {ECO:0000305}.
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DR   EMBL; BC080010; AAH80010.1; -; mRNA.
DR   RefSeq; NP_001087494.1; NM_001094025.1.
DR   RefSeq; XP_018109798.1; XM_018254309.1.
DR   AlphaFoldDB; Q68F35; -.
DR   SMR; Q68F35; -.
DR   DNASU; 447318; -.
DR   GeneID; 447318; -.
DR   KEGG; xla:447318; -.
DR   CTD; 447318; -.
DR   Xenbase; XB-GENE-6254012; slc20a1.S.
DR   OrthoDB; 712010at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 447318; Expressed in blastula and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001204; Phos_transporter.
DR   PANTHER; PTHR11101; PTHR11101; 1.
DR   Pfam; PF01384; PHO4; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Phosphate transport; Reference proteome; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..685
FT                   /note="Sodium-dependent phosphate transporter 1-A"
FT                   /id="PRO_0000080777"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        517..537
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        565..585
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        606..626
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        656..676
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          438..458
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          483..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        493..513
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   685 AA;  74609 MW;  58F7DE9CB728E5C0 CRC64;
     MESTTAFSAV TSALGTLDVH IMAPYLWMLV LGFVIAFVLA FSVGANDVAN SFGTAVGSGV
     VTLRQACILA SIFETVGSVL LGAKVSETIR KGLIDVTMYN STQELLMAGS ISAMFGSAVW
     QLAASFMKLP ISGTHCIVGA TIGFSLVAKG QQGVKWIELL RIVLSWFISP LLSGIMSALL
     FLFVRMFILR KADPVPNGLR ALPVFYACTI GINLFSIMFT GAPLLGFDKV PLWGIILISV
     GCAVLCALIV WFVVCPRMKR KIECEFKSSP SESPLMDKKN QELRCPILKP DPEDLKLPVD
     GGIVAEVKVP ILDMVSVSRT EERTVTFKMG ECDDPIEKEK LNSMETNIDQ PTNGSVQLPN
     GNHVQFSQAV SNQMNSSGQY QYHTVHKDSG LYKDLLHKLH LAKMGDCMGD SGDKPLRRNN
     SYTSYTMAIC GMPLDSLRNR DTEARPDEAE KSTVHGADGK KRIRMDSYTS YCNAVADTHM
     DVEAEEQEEG SVEDVETDRK SSSSSLEERH DQDKPEVSLL FQFLQILTAC FGSFAHGGND
     VSNAIGPLVA LYLVYETGDV TTKAATPIWL LLYGGIGICI GLWVWGRRVI QTMGKDLTPI
     TPSSGFSIEL ASALTVVIAS NVGLPISTTH CKVGSVVSVG WLRSKKAVDW RLFRNIFLAW
     FVTVPISGLI SAGIMALFKY AILKV