S226B_XENLA
ID S226B_XENLA Reviewed; 552 AA.
AC Q66J52;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Solute carrier family 22 member 6-B;
DE AltName: Full=Organic cation transporter 1-B;
DE AltName: Full=Renal organic anion transporter 1-B;
DE Short=ROAT1-B;
GN Name=slc22a6-b; Synonyms=oat1-b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the renal elimination of endogenous and exogenous
CC organic anions. Mediates the sodium-independent uptake of p-
CC aminohippurate (PAH), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl)
CC guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and
CC edaravone sulfate. PAH uptake is inhibited by furosemide, steviol,
CC phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187,
CC benzylpenicillin, furosemide, indomethacin, bumetamide, losartan,
CC probenecid, phenol red, urate, and alpha-ketoglutarate (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- PTM: Glycosylated. Glycosylation is necessary for proper targeting of
CC the transporter to the plasma membrane (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
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DR EMBL; BC081057; AAH81057.1; -; mRNA.
DR RefSeq; NP_001087663.1; NM_001094194.1.
DR AlphaFoldDB; Q66J52; -.
DR SMR; Q66J52; -.
DR MaxQB; Q66J52; -.
DR DNASU; 447487; -.
DR GeneID; 447487; -.
DR KEGG; xla:447487; -.
DR CTD; 447487; -.
DR Xenbase; XB-GENE-5842265; slc22a6.S.
DR OrthoDB; 704438at2759; -.
DR Proteomes; UP000186698; Chromosome 4S.
DR Bgee; 447487; Expressed in kidney.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004749; Orgcat_transp/SVOP.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00898; 2A0119; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..552
FT /note="Solute carrier family 22 member 6-B"
FT /id="PRO_0000324176"
FT TOPO_DOM 1..16
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..137
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..164
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..225
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..250
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..336
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 357
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 379..398
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 420..426
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 448..459
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 481..487
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 509..552
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 552 AA; 61665 MW; CC5FCB5A11A97454 CRC64;
MAFQEILESL GGMGRYQVIH VVLLSLPVFM LASHNLMQNF TAATPSHHCR INGTYEETNF
TGPWLRALLP MTPTGEFSKC LRYTTPQYEL LENNLTQSYD DLETEPCLDG WVYDHSEFAS
TIITQWDLVC NHRRMRQVAQ SIYMAGVLVG SILFGGLSDK FGRRPLNIWS NLQMFVTGIC
AAFSPNYIWY CIFRFLTGVA FSGIVLNSYS LTVEWIPTGN RAFTSTATGY CYTMGQLVLV
GLAFIIRDWQ WLQLAASIPF FFYFLYSWWI PESGRWLVLS GKPEVACKAL KKVAQINGKK
EAGEKLTVEI LKSSMQREIN ASHNSTYSAL DLVRTPVVRR ISFCISCTWF STSFAYYGLA
LDLQSFGVSI YIIQIIFGTV DIPAKFISYF ITTYVGRRVS QAITLILAGI AILVNISVPQ
DFQTVRTAMA VFGKGCLAAS FNCLYLYTGE LYPTVIRQTG MGLGAMMARL GGIIAPLAQM
TGDIYHSLPL IIFGCLPILS GIAGCFLPET LGVPLPETIE EVESPDKQQK DVNVSAKIPL
KETELYNMKT DV
