ID   S22A7_BOVIN             Reviewed;         547 AA.
AC   A6QLW8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Solute carrier family 22 member 7;
DE   AltName: Full=Organic anion transporter 2;
GN   Name=SLC22A7; Synonyms=OAT2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates sodium-independent multispecific organic anion
CC       transport. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass membrane
CC       protein. Note=Apical side of the renal tubule. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC       Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
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DR   EMBL; BC148112; AAI48113.1; -; mRNA.
DR   RefSeq; NP_001094517.1; NM_001101047.2.
DR   AlphaFoldDB; A6QLW8; -.
DR   SMR; A6QLW8; -.
DR   STRING; 9913.ENSBTAP00000008336; -.
DR   PaxDb; A6QLW8; -.
DR   PeptideAtlas; A6QLW8; -.
DR   PRIDE; A6QLW8; -.
DR   GeneID; 407224; -.
DR   KEGG; bta:407224; -.
DR   CTD; 10864; -.
DR   eggNOG; KOG0255; Eukaryota.
DR   InParanoid; A6QLW8; -.
DR   OrthoDB; 435631at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR004749; Orgcat_transp/SVOP.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00898; 2A0119; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..547
FT                   /note="Solute carrier family 22 member 7"
FT                   /id="PRO_0000317480"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        367..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        465..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        492..512
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          91..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          521..547
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   547 AA;  60004 MW;  4F4CD1B0DE4AD9A9 CRC64;
     MGFEELLDKV GGFGPFQLRN VALLALPRVL LPMHFLLPIF LAAVPAHRCA LPGVPDNFSN
     EDAWLEAHLP REPDGRLSAC LRFTHPQALP NSTLWGEGQN SGEQPEGEPS TVPCPQGWEY
     NHSEFSSTIA TEWDLVCEQK GLNKAISTFF FAGVLVGAEV YGYLSDRFGR RRLLLVAYVS
     SLALGLASAA SVSYIMFAIT RTLTGMALAG FTIIVMPLEL EWLDVRHRTV AGVLSSTFWT
     GGVMLLALIG YLIRDWRWLL LTVTLPCVPG ILTLWWVPES ARWLLTQGRV EEAHRYLLRC
     ARLNGPPVGE DSLSREALNK VAAAERMVRR PSYLDLFRTP RLRYISLCCM VVWFGVNFSY
     YGVSLDLSGL GLNVYLTQLV FGAVELPSKL LVYLSVRHAG RRLTMAGTLL GAALAVGLRI
     LVSPEMKSWS TALAVMGKAF SEAAFTTAYL FTSELYPTVL RQTGMGLTAL VGRLGGSLAP
     LAALLDGVWL SLPKLAYGGI ALLAACTALL LPETKQAQLP ETIQDVERKS APSSLQEEEM
     PMKQVQD