S22A7_PIG
ID S22A7_PIG Reviewed; 547 AA.
AC Q1RPP5;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Solute carrier family 22 member 7;
DE AltName: Full=Organic anion transporter 2;
GN Name=SLC22A7; Synonyms=OAT2;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Bahn A., Krick W., Braun I.M., Hagos Y., Burckhardt G.;
RT "Organic anion transporter 2 (OAT2) facilitates basolateral transport of
RT uric acid in liver and kidneys.";
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates sodium-independent multispecific organic anion
CC transport. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass membrane
CC protein. Note=Apical side of the renal tubule. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
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DR EMBL; AM180267; CAJ55262.1; -; mRNA.
DR RefSeq; NP_001038082.1; NM_001044617.1.
DR AlphaFoldDB; Q1RPP5; -.
DR SMR; Q1RPP5; -.
DR STRING; 9823.ENSSSCP00000026455; -.
DR PaxDb; Q1RPP5; -.
DR PeptideAtlas; Q1RPP5; -.
DR PRIDE; Q1RPP5; -.
DR Ensembl; ENSSSCT00000025126; ENSSSCP00000026455; ENSSSCG00000027796.
DR Ensembl; ENSSSCT00005049792; ENSSSCP00005030741; ENSSSCG00005030961.
DR Ensembl; ENSSSCT00015038913; ENSSSCP00015015472; ENSSSCG00015029260.
DR Ensembl; ENSSSCT00030082328; ENSSSCP00030037805; ENSSSCG00030058988.
DR Ensembl; ENSSSCT00035061153; ENSSSCP00035024624; ENSSSCG00035045978.
DR Ensembl; ENSSSCT00040025551; ENSSSCP00040010785; ENSSSCG00040018854.
DR Ensembl; ENSSSCT00055042083; ENSSSCP00055033509; ENSSSCG00055021278.
DR Ensembl; ENSSSCT00060045405; ENSSSCP00060019443; ENSSSCG00060033482.
DR Ensembl; ENSSSCT00070044873; ENSSSCP00070037804; ENSSSCG00070022570.
DR GeneID; 733693; -.
DR KEGG; ssc:733693; -.
DR CTD; 10864; -.
DR VGNC; VGNC:92983; SLC22A7.
DR eggNOG; KOG0255; Eukaryota.
DR GeneTree; ENSGT00940000154922; -.
DR HOGENOM; CLU_001265_33_3_1; -.
DR InParanoid; Q1RPP5; -.
DR OMA; FPMETRA; -.
DR OrthoDB; 435631at2759; -.
DR TreeFam; TF315847; -.
DR Reactome; R-SSC-561048; Organic anion transport.
DR Reactome; R-SSC-9749641; Aspirin ADME.
DR Proteomes; UP000008227; Chromosome 7.
DR Proteomes; UP000314985; Chromosome 7.
DR Bgee; ENSSSCG00000027796; Expressed in liver and 15 other tissues.
DR ExpressionAtlas; Q1RPP5; differential.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004749; Orgcat_transp/SVOP.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00898; 2A0119; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..547
FT /note="Solute carrier family 22 member 7"
FT /id="PRO_0000317483"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 465..485
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 492..512
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 521..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 59844 MW; 4F74BC366FAE94A7 CRC64;
MAFEELLDKV GGFGPFQLWN VALLALPRVL LPMHFLLPIF LTAVPAHRCA LPGAPANFSH
QDAWLEAHLP REPDGRFSSC LRFTHSRALP NTTLWGLGQS PGEQLEGEPS TVPCPQGWEY
DHSEFSSTIA TEWDLVCEQK GLNRATSTFF FAGVLVGAVA FGYLSDRFGR RRLLLVAYVS
ALVLGLVSAA SVSYTMFAIT RTLTGTALAG FTIIVMPLEL EWLDVGHRTV AGVLSSTFWT
GGVMLLALVG YLIRDWRWLL LAVTLPCAPG ILSLWWVPES ARWLLTQGRV EDAHRYLLRC
ARLNGRPVGE DGLSREALSK VAAAERVVRR PSYVDLFRTP RLRHISLCCM VVWFGVNFSY
YGLSLDVSGL GLNVYQTQLL FGAVELPSKL LVYLSVRHAG RRLTLAGTLL GTSLSLGFRL
LVSSEMKSWS TALAVLGKGF SEAAFTTAYL FTSELYPTVL RQTGMGLTAL VGRLGGSLAP
LAALLDGVWL SLPKLAYGGI ALLAACTALL LPETKQAQLP ETIQDVERKS APSSLQEEEM
PMKQVQD
