ID   S22A7_RABIT             Reviewed;         542 AA.
AC   Q3YAW7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Solute carrier family 22 member 7;
DE   AltName: Full=Organic anion transporter 2;
DE   AltName: Full=rbOAT2;
GN   Name=SLC22A7; Synonyms=OAT2;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Zhang X., Wright S.H.;
RT   "Molecular cloning and functional characterization of rabbit organic anion
RT   transporter 2 (rbOAT2).";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates sodium-independent multispecific organic anion
CC       transport. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass membrane
CC       protein. Note=Apical side of the renal tubule. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC       Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
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DR   EMBL; DQ146940; AAZ79452.1; -; mRNA.
DR   RefSeq; NP_001076111.1; NM_001082642.1.
DR   AlphaFoldDB; Q3YAW7; -.
DR   SMR; Q3YAW7; -.
DR   STRING; 9986.ENSOCUP00000005016; -.
DR   GeneID; 100009335; -.
DR   KEGG; ocu:100009335; -.
DR   CTD; 10864; -.
DR   eggNOG; KOG0255; Eukaryota.
DR   InParanoid; Q3YAW7; -.
DR   OrthoDB; 435631at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR004749; Orgcat_transp/SVOP.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00898; 2A0119; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..542
FT                   /note="Solute carrier family 22 member 7"
FT                   /id="PRO_0000317485"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        402..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        430..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        464..484
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        491..511
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   542 AA;  59358 MW;  E8D1A0EEC38EF2AC CRC64;
     MGFEELLEQV GGFGPFQLRN LALLALPRIL LPLHFLLPVF LAAVPAHRCA LPGTPANLSF
     QDAWLEAYLP READGTFSSC LRFTHPQAVP NITLGREGRS PGDLQGNRSS MPCTQGWEYD
     RSEFSSTIAT EWDLVCEQKD LSRAASTFFF VGVLVGAVAF GYLSDRFGRR RLLLVAYVSA
     LVLGLASAAS VSYVMFAITR TLTGSALAGF TIIVMPLELE WLDVEHRIVA GVLSSTFWTG
     GVMLLALVGY LIRDWRWLLL AVTLPLAPGI LSLWWVPESA RWLLTQGRVE EAQRYLLRCA
     RLNGRPVPQD GLSREALSEV AAGERVVRRP SYLDLFRTPR LRHISLCCMV VWFGVNFSYY
     GQSLAVSGLG LNVYQTQLLF GAVELPSKLL VYLSVRHAGR RLTQAGTLMG AALALGIRLL
     VASERSSWST ALAVMGKGFS EAAFTTAYLF TSELYPTVLR QTGMGLTALV GRLGGSLAPL
     AALLDGVWLS LPKLAYGGIA LLAACTALLL PETRRAQLPE TIQDVERKSL QEEEMAMKQV
     QT