S22A8_PIG
ID S22A8_PIG Reviewed; 543 AA.
AC Q70BM6;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Solute carrier family 22 member 8;
DE AltName: Full=Organic anion transporter 3;
DE AltName: Full=pOAT3;
GN Name=SLC22A8; Synonyms=OAT3;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney;
RA Bahn A., Braun I.M., Burckhardt G., Krick W., Hagos Y.;
RT "Cloning of the pig renal organic anion transporter 3 (pOAT3).";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an important role in the excretion/detoxification of
CC endogenous and exogenous organic anions, especially from the brain and
CC kidney. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000305}; Multi-
CC pass membrane protein {ECO:0000305}. Note=Localizes on the brush border
CC membrane of the choroid epithelial cells. Localizes to the basolateral
CC membrane of the proximal tubular cells. Localizes on the abluminal and
CC possibly, luminal membrane of the brain capillary endothelial cells
CC (BCEC) (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
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DR EMBL; AJ587003; CAE53047.1; -; mRNA.
DR RefSeq; NP_999620.1; NM_214455.1.
DR RefSeq; XP_005660832.1; XM_005660775.1.
DR RefSeq; XP_005660834.1; XM_005660777.2.
DR RefSeq; XP_013849646.1; XM_013994192.1.
DR RefSeq; XP_013849647.1; XM_013994193.1.
DR AlphaFoldDB; Q70BM6; -.
DR SMR; Q70BM6; -.
DR STRING; 9823.ENSSSCP00000024173; -.
DR PaxDb; Q70BM6; -.
DR PeptideAtlas; Q70BM6; -.
DR Ensembl; ENSSSCT00000032013; ENSSSCP00000024173; ENSSSCG00000029516.
DR Ensembl; ENSSSCT00005040049; ENSSSCP00005024515; ENSSSCG00005025053.
DR Ensembl; ENSSSCT00005040084; ENSSSCP00005024528; ENSSSCG00005025053.
DR Ensembl; ENSSSCT00015081350; ENSSSCP00015032916; ENSSSCG00015060814.
DR Ensembl; ENSSSCT00025102474; ENSSSCP00025045347; ENSSSCG00025074375.
DR Ensembl; ENSSSCT00030016495; ENSSSCP00030007396; ENSSSCG00030011998.
DR Ensembl; ENSSSCT00035059724; ENSSSCP00035024012; ENSSSCG00035044945.
DR Ensembl; ENSSSCT00040061205; ENSSSCP00040025729; ENSSSCG00040045565.
DR Ensembl; ENSSSCT00045057285; ENSSSCP00045040042; ENSSSCG00045033488.
DR Ensembl; ENSSSCT00050013766; ENSSSCP00050005674; ENSSSCG00050010226.
DR Ensembl; ENSSSCT00055008416; ENSSSCP00055006659; ENSSSCG00055004259.
DR Ensembl; ENSSSCT00060048360; ENSSSCP00060020716; ENSSSCG00060035672.
DR Ensembl; ENSSSCT00065008947; ENSSSCP00065003766; ENSSSCG00065006652.
DR GeneID; 407774; -.
DR KEGG; ssc:407774; -.
DR CTD; 9376; -.
DR VGNC; VGNC:92984; SLC22A8.
DR eggNOG; KOG0255; Eukaryota.
DR GeneTree; ENSGT00940000154901; -.
DR HOGENOM; CLU_001265_33_3_1; -.
DR InParanoid; Q70BM6; -.
DR OMA; RIPLQPC; -.
DR OrthoDB; 464838at2759; -.
DR TreeFam; TF315847; -.
DR Reactome; R-SSC-561048; Organic anion transport.
DR Proteomes; UP000008227; Chromosome 2.
DR Proteomes; UP000314985; Unplaced.
DR Bgee; ENSSSCG00000029516; Expressed in adult mammalian kidney and 12 other tissues.
DR Genevisible; Q70BM6; SS.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015075; F:ion transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0009636; P:response to toxic substance; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004749; Orgcat_transp/SVOP.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00898; 2A0119; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Detoxification; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..543
FT /note="Solute carrier family 22 member 8"
FT /id="PRO_0000273442"
FT TOPO_DOM 1..21
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..124
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..181
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..212
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..237
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..328
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 350..355
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 377..388
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 410..412
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 434..472
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 473..493
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 494..543
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 513..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 81
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 543 AA; 59387 MW; FDCE29C334D93984 CRC64;
MTFAELVDRV GSKGPFQLLH TVLLGLPILG MANHNLLQIF TAPTPAHHCR PPPNASAGPW
VLPTGLNGKP ETCLRFVYPP NASLPNDTRG ATEPCLDGWI YNIVDRDSIV TEWDLVCSSS
KLKEMAQSVF MAGILVGGLV LGALSDRFGR KPILIFSYLL LGASGSGAAF SPTFSIYAVF
RFLCGFSISG ISLSTAILNV EWVSTRFRAI KSIAVGFFYT FGQFILPGLA YAIPQWRWLQ
LTVSVPFLTF FLLSWWLPES IRWMVLSGKS SKALKTLRQV AIFNGKKEEG EKLSLEELKL
NLQKEISLAK ARHGIADLFR TPVLRRVTLC LSLAWFATGF AYYSLAMGVE EFGVNLYVLQ
LIFGGVDVPA KFITMLSISY LGRHITEGIV LLLAGGCILA LIFVPLDLMT LRTVLAVFGK
GCLSGSFSCL FLYTSELYPT VIRQTGMGAS NLWARVGSMT APLVKITGEL QPFIPNIIFG
TIALLGGSAA LFLPETLNRP LPETIEDIET WSLRAKEPKP EPEAEKSSQR IPLQPCEPGP
GPS
