S22A9_BOVIN
ID S22A9_BOVIN Reviewed; 552 AA.
AC Q2KIV1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Solute carrier family 22 member 9;
GN Name=SLC22A9;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Testis;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sodium-independent organic anion transporter which exhibits
CC high specificity for sulfated conjugates of xenobiotics and steroid
CC hormones. It is also specifically activated by 3 to 5 carbons-
CC containing short-chain fatty acids/SCFAs, including propionate,
CC butyrate and valerate. May operate the exchange of sulfated organic
CC components against short-chain fatty acids/SCFAs at the sinusoidal
CC membrane of hepatocytes (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Note=Enriched at the sinusoidal
CC part of the plasma membrane. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
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DR EMBL; BC112499; AAI12500.1; -; mRNA.
DR RefSeq; NP_001039471.1; NM_001046006.1.
DR AlphaFoldDB; Q2KIV1; -.
DR SMR; Q2KIV1; -.
DR STRING; 9913.ENSBTAP00000025892; -.
DR PaxDb; Q2KIV1; -.
DR Ensembl; ENSBTAT00000025892; ENSBTAP00000025892; ENSBTAG00000039463.
DR GeneID; 508494; -.
DR KEGG; bta:508494; -.
DR CTD; 114571; -.
DR VEuPathDB; HostDB:ENSBTAG00000039463; -.
DR eggNOG; KOG0255; Eukaryota.
DR GeneTree; ENSGT00940000161239; -.
DR InParanoid; Q2KIV1; -.
DR OMA; WLIMTNK; -.
DR OrthoDB; 464838at2759; -.
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000039463; Expressed in liver and 19 other tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015301; F:anion:anion antiporter activity; ISS:UniProtKB.
DR GO; GO:0015636; F:short-chain fatty acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0009914; P:hormone transport; ISS:UniProtKB.
DR GO; GO:0015711; P:organic anion transport; IBA:GO_Central.
DR GO; GO:0015913; P:short-chain fatty acid import; ISS:UniProtKB.
DR GO; GO:0043252; P:sodium-independent organic anion transport; ISS:UniProtKB.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..552
FT /note="Solute carrier family 22 member 9"
FT /id="PRO_0000317528"
FT TOPO_DOM 1..15
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..143
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..177
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..203
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..259
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..349
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 350..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369..377
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 399..406
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 428..435
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 457..468
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 469..489
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 490..494
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 495..515
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 516..552
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 525..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..543
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 39
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 107
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 552 AA; 61540 MW; 0E9FAD89A10DED73 CRC64;
MAFQDLLDQV GGLGRFQILQ MLLLCISSLI TYPHILLENF TAAVPGHQCW VHILNNNTDS
ANATGTLSPD ALLRISIPLD SNLRPEKCRR FSRPQWQLLN LNRTFPNITD LDTESCVDGW
VYDQSIFTST IVTEWDLVCE SQSLKSMAKF LFMAGMLVGS IVYGHLSDRF GRRLIFRCCL
LQLAITDTSA AFAPTYLIYC SLRFLAGFST MSILTNCTVL IVEWTVPRFQ VMGMTLSICA
ACLGQIILGG LAFAIRDWHT LQLVFSVPLF VLFLSSRWLA ESARWLIITN RPEEGLKELK
KAAHRNGRKN AGDALTMEVL RSAMQEELEA AQIKSSVFDL FRTPNLRKRI CLLSFVRFAN
FMSFFGLILH LQYMGSNVFL FQVLFGAVNL PANCVAFWAL NHLGRQVSQT LFLFLLGISI
LAITFVPQEM QTLRMAVSAL GIAVSSVTLM CSFAHGNELT PTVLRVTASG FLGIASNIGA
ALAPLLMILT VYSPHLPWII YGVCSILGGL VVPLLPETRN KPLPDSIQEV EKERKDSRKA
KPEGTFMKVT QF
