S22AA_HUMAN
ID S22AA_HUMAN Reviewed; 541 AA.
AC Q63ZE4; Q68CJ0;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Solute carrier family 22 member 10;
DE AltName: Full=Organic anion transporter 5;
GN Name=SLC22A10; Synonyms=OAT5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=15221005; DOI=10.1038/sj.onc.1207782;
RA Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S.,
RA Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S.,
RA Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.;
RT "Expression profiling and differential screening between hepatoblastomas
RT and the corresponding normal livers: identification of high expression of
RT the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.";
RL Oncogene 23:5901-5911(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=11327718; DOI=10.1006/bbrc.2001.4774;
RA Sun W., Wu R.R., van Poelje P.D., Erion M.D.;
RT "Isolation of a family of organic anion transporters from human liver and
RT kidney.";
RL Biochem. Biophys. Res. Commun. 283:417-422(2001).
RN [4]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=12372408; DOI=10.1016/s0006-291x(02)02343-4;
RA Eraly S.A., Nigam S.K.;
RT "Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine
RT transporters.";
RL Biochem. Biophys. Res. Commun. 297:1159-1166(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q63ZE4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q63ZE4-2; Sequence=VSP_056645, VSP_056646, VSP_056647;
CC -!- TISSUE SPECIFICITY: Detected in fetal and adult liver, and in adult
CC kidney. {ECO:0000269|PubMed:11327718, ECO:0000269|PubMed:12372408}.
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
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DR EMBL; AB075876; BAD38658.1; -; mRNA.
DR EMBL; AP001858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP001880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP003420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK001421; DAA01503.1; -; mRNA.
DR CCDS; CCDS41661.1; -. [Q63ZE4-1]
DR RefSeq; NP_001034841.3; NM_001039752.3. [Q63ZE4-1]
DR RefSeq; XP_011543318.1; XM_011545016.2. [Q63ZE4-1]
DR AlphaFoldDB; Q63ZE4; -.
DR SMR; Q63ZE4; -.
DR STRING; 9606.ENSP00000327569; -.
DR DrugBank; DB00286; Conjugated estrogens.
DR DrugBank; DB01032; Probenecid.
DR DrugBank; DB00936; Salicylic acid.
DR TCDB; 2.A.1.19.27; the major facilitator superfamily (mfs).
DR GlyGen; Q63ZE4; 2 sites.
DR iPTMnet; Q63ZE4; -.
DR PhosphoSitePlus; Q63ZE4; -.
DR BioMuta; SLC22A10; -.
DR DMDM; 313104183; -.
DR EPD; Q63ZE4; -.
DR MassIVE; Q63ZE4; -.
DR PaxDb; Q63ZE4; -.
DR PeptideAtlas; Q63ZE4; -.
DR PRIDE; Q63ZE4; -.
DR ProteomicsDB; 65900; -. [Q63ZE4-1]
DR ProteomicsDB; 66001; -.
DR Antibodypedia; 43868; 30 antibodies from 12 providers.
DR DNASU; 387775; -.
DR Ensembl; ENST00000332793.11; ENSP00000327569.6; ENSG00000184999.13. [Q63ZE4-1]
DR GeneID; 387775; -.
DR KEGG; hsa:387775; -.
DR MANE-Select; ENST00000332793.11; ENSP00000327569.6; NM_001039752.4; NP_001034841.3.
DR UCSC; uc009yor.4; human. [Q63ZE4-1]
DR CTD; 387775; -.
DR DisGeNET; 387775; -.
DR GeneCards; SLC22A10; -.
DR HGNC; HGNC:18057; SLC22A10.
DR HPA; ENSG00000184999; Tissue enriched (liver).
DR MIM; 607580; gene.
DR neXtProt; NX_Q63ZE4; -.
DR OpenTargets; ENSG00000184999; -.
DR PharmGKB; PA38283; -.
DR VEuPathDB; HostDB:ENSG00000184999; -.
DR eggNOG; KOG0255; Eukaryota.
DR GeneTree; ENSGT00940000163667; -.
DR HOGENOM; CLU_001265_33_3_1; -.
DR InParanoid; Q63ZE4; -.
DR OMA; HFIELIP; -.
DR OrthoDB; 464838at2759; -.
DR PhylomeDB; Q63ZE4; -.
DR TreeFam; TF315847; -.
DR PathwayCommons; Q63ZE4; -.
DR BioGRID-ORCS; 387775; 16 hits in 1073 CRISPR screens.
DR ChiTaRS; SLC22A10; human.
DR GeneWiki; SLC22A10; -.
DR GenomeRNAi; 387775; -.
DR Pharos; Q63ZE4; Tdark.
DR PRO; PR:Q63ZE4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q63ZE4; protein.
DR Bgee; ENSG00000184999; Expressed in liver and 50 other tissues.
DR ExpressionAtlas; Q63ZE4; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015711; P:organic anion transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..541
FT /note="Solute carrier family 22 member 10"
FT /id="PRO_0000233716"
FT TOPO_DOM 1..15
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..145
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..193
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..230
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..259
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..349
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 371..377
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 399..406
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 428..436
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 437..457
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 458..472
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 473..493
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 494..495
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 496..516
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 517..541
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..155
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15221005"
FT /id="VSP_056645"
FT VAR_SEQ 383..424
FT /note="VLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSILANT -> KCRPCV
FT WLWHVWESAVLLLLFPVLLFTSLNSSPLFSGQELQE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15221005"
FT /id="VSP_056646"
FT VAR_SEQ 425..541
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15221005"
FT /id="VSP_056647"
SQ SEQUENCE 541 AA; 60257 MW; 73016CF8246BE9D9 CRC64;
MAFEELLSQV GGLGRFQMLH LVFILPSLML LIPHILLENF AAAIPGHRCW VHMLDNNTGS
GNETGILSED ALLRISIPLD SNLRPEKCRR FVHPQWQLLH LNGTIHSTSE ADTEPCVDGW
VYDQSYFPST IVTKWDLVCD YQSLKSVVQF LLLTGMLVGG IIGGHVSDRF GRRFILRWCL
LQLAITDTCA AFAPTFPVYC VLRFLAGFSS MIIISNNSLP ITEWIRPNSK ALVVILSSGA
LSIGQIILGG LAYVFRDWQT LHVVASVPFF VFFLLSRWLV ESARWLIITN KLDEGLKALR
KVARTNGIKN AEETLNIEVV RSTMQEELDA AQTKTTVCDL FRNPSMRKRI CILVFLRFAN
TIPFYGTMVN LQHVGSNIFL LQVLYGAVAL IVRCLALLTL NHMGRRISQI LFMFLVGLSI
LANTFVPKEM QTLRVALACL GIGCSAATFS SVAVHFIELI PTVLRARASG IDLTASRIGA
ALAPLLMTLT VFFTTLPWII YGIFPIIGGL IVFLLPETKN LPLPDTIKDV ENQKKNLKEK
A
