S22AD_MOUSE
ID S22AD_MOUSE Reviewed; 551 AA.
AC Q6A4L0; E9QP74; Q8VC89;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Solute carrier family 22 member 13;
DE AltName: Full=Organic cation transporter-like 3;
DE Short=ORCTL-3;
GN Name=Slc22a13; Synonyms=Orctl3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Mount D.B.;
RT "Sequence of murine organic cation transporter-like 3 (ORCTL-3).";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS THR-77; ILE-506 AND
RP SER-535.
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF529220; AAQ09528.1; -; mRNA.
DR EMBL; AC055818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC021449; AAH21449.1; -; mRNA.
DR CCDS; CCDS40802.1; -.
DR RefSeq; NP_598741.2; NM_133980.3.
DR AlphaFoldDB; Q6A4L0; -.
DR SMR; Q6A4L0; -.
DR STRING; 10090.ENSMUSP00000081855; -.
DR GlyGen; Q6A4L0; 4 sites.
DR iPTMnet; Q6A4L0; -.
DR PhosphoSitePlus; Q6A4L0; -.
DR jPOST; Q6A4L0; -.
DR PaxDb; Q6A4L0; -.
DR PRIDE; Q6A4L0; -.
DR ProteomicsDB; 260758; -.
DR DNASU; 102570; -.
DR Ensembl; ENSMUST00000084797; ENSMUSP00000081855; ENSMUSG00000074028.
DR GeneID; 102570; -.
DR KEGG; mmu:102570; -.
DR UCSC; uc009sal.2; mouse.
DR CTD; 9390; -.
DR MGI; MGI:2143107; Slc22a13.
DR VEuPathDB; HostDB:ENSMUSG00000074028; -.
DR eggNOG; KOG0255; Eukaryota.
DR GeneTree; ENSGT00940000154607; -.
DR HOGENOM; CLU_001265_33_3_1; -.
DR InParanoid; Q6A4L0; -.
DR OMA; YYMFAQV; -.
DR OrthoDB; 704438at2759; -.
DR PhylomeDB; Q6A4L0; -.
DR TreeFam; TF315847; -.
DR Reactome; R-MMU-197264; Nicotinamide salvaging.
DR BioGRID-ORCS; 102570; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Slc22a13; mouse.
DR PRO; PR:Q6A4L0; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q6A4L0; protein.
DR Bgee; ENSMUSG00000074028; Expressed in right kidney and 60 other tissues.
DR Genevisible; Q6A4L0; MM.
DR GO; GO:0016324; C:apical plasma membrane; ISO:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0090416; F:nicotinate transmembrane transporter activity; ISO:MGI.
DR GO; GO:0045922; P:negative regulation of fatty acid metabolic process; IDA:UniProtKB.
DR GO; GO:2001142; P:nicotinate transport; ISO:MGI.
DR GO; GO:0002854; P:positive regulation of T cell mediated cytotoxicity directed against tumor cell target; ISO:MGI.
DR GO; GO:0015747; P:urate transport; ISO:MGI.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..551
FT /note="Solute carrier family 22 member 13"
FT /id="PRO_0000230783"
FT TOPO_DOM 1..22
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..142
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..167
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..224
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 246..251
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..332
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 354
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 376..404
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 426..427
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 449..452
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 474..478
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 479..499
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 500..551
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 74
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 77
FT /note="A -> T (in strain: FVB/N)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT VARIANT 506
FT /note="T -> I (in strain: FVB/N)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT VARIANT 535
FT /note="L -> S (in strain: FVB/N)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT CONFLICT 402
FT /note="I -> V (in Ref. 1; AAQ09528)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 551 AA; 60724 MW; 2DAAE51ED8352724 CRC64;
MAQFAQVMAE VGDFGRFQVR LTILMGIPNF LAAFFIFGQV FMVLDEAHHC SVSWVKNHTF
NLSAAEQLAI SIPNDTAGRP ESCLMFRPPP DSASLEDILS HRFNETQACD SGWDYPENRP
QSLKKEFDLV CDRKNLKKTS QSVFMAGLLV GALVFGPVCD WIGRRPSLLM QVLLSGITSM
ATAFVSSFEL YLALRFVLAT ANAGFLLSTN VLISEWVGPS WRTQAVVLAQ SNVALGQMVL
AGLAYGVRNW RLLQITGTAP VLLLFFYFWV LPESPRWLLS QGRTEEAKQL VQKAALVNGR
PLSPELLNQL VPEKTGPSGN ALDLFRHPHL RKVTLILIAV WFVDSLVYYS LSFQVGDFGL
DIYVTQLIFG AVEMPGRFLS VLMMEKLGRK WSQLCTLTLA GIMYIIIIFI PGDLPTVVTV
LAVVGKFASA AAFTISYVYT AELFPTIIRQ TGMGLVSIFS RVGGIITPLV MLLEQYHQAI
PMVIFGSLPI GAGLLCALLP ETRGQTLKDT LQDLEQGLPA GSHKTAPQRQ DMEALGRTSS
VRVAVVKSSY F
