ID   S22AF_XENLA             Reviewed;         531 AA.
AC   Q6NUB3;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Solute carrier family 22 member 15;
GN   Name=slc22a15;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably transports organic cations. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC       Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH68683.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC068683; AAH68683.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001084547.1; NM_001091078.1.
DR   AlphaFoldDB; Q6NUB3; -.
DR   SMR; Q6NUB3; -.
DR   DNASU; 414494; -.
DR   GeneID; 414494; -.
DR   KEGG; xla:414494; -.
DR   CTD; 414494; -.
DR   Xenbase; XB-GENE-6256479; slc22a15.1.L.
DR   OrthoDB; 464838at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 414494; Expressed in liver and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..531
FT                   /note="Solute carrier family 22 member 15"
FT                   /id="PRO_0000338621"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        327..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        450..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        52
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        58
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        83
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        512
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   531 AA;  58019 MW;  0A79BCEB48C0C74F CRC64;
     MEVEGALKLV GEMGVYQIYL SFLLAVLLQL YSATEAILIT IVGVTPPYHW VNDSFVANGS
     QRNEYGGQLP AEGQHQYLVF DGNFTSIVSE WFLVGGAAYE VGVSSSVYFG GVLIGVICFG
     QLSDRFGRKP VYVTGLALEV TFAVMNALTP IFSMFLITRF LVGVMNGGMS LVAFVLLNEC
     IGSSYWAIAG SLGSMCFAVG IAQFALIGYF IRSWRLLAVL VNVQGAGVLA LSLCIPESPR
     WLYAQGRLHE AQESLVSLGR RNRKKFTSFT LRPRQKDSTH SANIITIYSN SILRHRTLVM
     MWVWFVCSLV YYGLTLSSGD LGGDIYLNLA LSGLAELPAY PLCMYLINHK RVGRRRSLAG
     FLFLGGGSCL LIMLVPVKEG SGPLSVLNSQ TLSLLGKLNI SASFNIVYIY SSELYPTCVR
     NLGMGVCSMF SRIGGIIAPF IPALRSVHWA LPFIVFGAAG VSAGLLSLFL PETLNVPLPE
     TLGDLQVTSY RRLETNGELM LHRHEEPGAF TNGSSEEEEE LDVMMESQSL L