ID   S22AF_XENTR             Reviewed;         534 AA.
AC   Q6DFR1;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Solute carrier family 22 member 15;
GN   Name=slc22a15;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably transports organic cations. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC       Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH76672.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC076672; AAH76672.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001005012.1; NM_001005012.1.
DR   AlphaFoldDB; Q6DFR1; -.
DR   SMR; Q6DFR1; -.
DR   DNASU; 448510; -.
DR   GeneID; 448510; -.
DR   KEGG; xtr:448510; -.
DR   CTD; 448510; -.
DR   Xenbase; XB-GENE-959503; slc22a15.1.
DR   InParanoid; Q6DFR1; -.
DR   OrthoDB; 464838at2759; -.
DR   Reactome; R-XTR-549127; Organic cation transport.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..534
FT                   /note="Solute carrier family 22 member 15"
FT                   /id="PRO_0000338622"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        327..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        450..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        52
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        58
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        83
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        513
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   534 AA;  57603 MW;  3C34E5DB56477EB3 CRC64;
     MEVEGALKLV GEMGIYQIYL SFLLAVLLQL YSATEAIIIT ILGATPPYHW MNDSLTANGS
     RGKQYGSQLP AEGEHGHVVF DGNFTSIVSE WFLVGGAAYE VSVSSSVYFG GVLIGVISFG
     QLSDRFGRKP VYVTGLALEV VFAVMNALTP IFPLFLLTRF LVGVMNGGMS LVAFVLLNEC
     IGASYWAAAG SLGSLCFAVG IAQFALIGYF IRSWRLLALL VNVQGAAVLA LSLCIPESPR
     WLHAQGRLRE AQESLLSLGR RNRRKVTSFT LCPRQKDSAH SANILTIYSN AILRQRTLIM
     MWVWFVCSLV YYGLTLSSGD LGGDIYLNLA LSGLAELPAY PLCMYLINHK RVGRRGSLAG
     FLCVGGGACL LIMLVPGKTG SGPLSVLNSQ TLSLLGKLNI SAAFNIVYIY SSELYPTCVR
     NLGMGVCSMF SRIGGIIAPF IPALRFAHWA LPFIVFGAAG VSAGLLSLLL PETLSAPLPE
     TLADLRGAPY RRLEPDGEAM LHRPQAELGA FTNGSSEEDE EEELDAVREC QALI