S22AG_BOVIN
ID S22AG_BOVIN Reviewed; 572 AA.
AC Q17QN9;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Solute carrier family 22 member 16;
DE AltName: Full=Carnitine transporter 2;
DE Short=CT2;
GN Name=SLC22A16;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: High affinity carnitine transporter; the uptake is partially
CC sodium-ion dependent. Thought to mediate the L-carnitine secretion
CC mechanism from testis epididymal epithelium into the lumen which is
CC involved in the maturation of spermatozoa. Also transports organic
CC cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of
CC TEA is inhibited by various organic cations. The uptake of doxorubicin
CC is sodium-independent (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Cell membrane {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI18254.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; BC118253; AAI18254.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001069792.2; NM_001076324.2.
DR AlphaFoldDB; Q17QN9; -.
DR SMR; Q17QN9; -.
DR STRING; 9913.ENSBTAP00000028664; -.
DR PaxDb; Q17QN9; -.
DR Ensembl; ENSBTAT00000028664; ENSBTAP00000028664; ENSBTAG00000010507.
DR GeneID; 614380; -.
DR KEGG; bta:614380; -.
DR CTD; 85413; -.
DR VEuPathDB; HostDB:ENSBTAG00000010507; -.
DR VGNC; VGNC:34724; SLC22A16.
DR eggNOG; KOG0255; Eukaryota.
DR GeneTree; ENSGT00940000160723; -.
DR HOGENOM; CLU_001265_33_4_1; -.
DR InParanoid; Q17QN9; -.
DR OMA; TEVYQSI; -.
DR OrthoDB; 762280at2759; -.
DR TreeFam; TF315847; -.
DR Proteomes; UP000009136; Chromosome 9.
DR Bgee; ENSBTAG00000010507; Expressed in mammary gland and 101 other tissues.
DR ExpressionAtlas; Q17QN9; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015101; F:organic cation transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0015695; P:organic cation transport; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Developmental protein; Differentiation; Glycoprotein;
KW Ion transport; Membrane; Reference proteome; Spermatogenesis;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..572
FT /note="Solute carrier family 22 member 16"
FT /id="PRO_0000318990"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 476..496
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 503..523
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 315
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 559
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 572 AA; 64355 MW; 821621260A68ED91 CRC64;
MGSSNLELIF DSVGHFGRYQ IFLYFICAFQ NISCGIHYLA SVFLSVSPQH TCRPPGNVSQ
VLFQDLSTWQ LEDIWTQFSV GREDRILVQL QDGAIWELTS CQRFRRDDQS SLDYEYSGQK
SSFPCLDGYI YDRSKWLSTV VTQWDLVCNR EWFGRLIQPT FMFGVLLGAV IFGYLSDRAG
RRLVLWASST GVFLFGIAAA FTFDYYSFIV ARFLLAISGS GYLVVVFVYV TEFVGMKSRT
WASIHLHSFF AFGTMVVALT GYFVRTWWIY QIVLSSVTVP FVLCCWMLPE TPFWLISGGK
YEEAQKVIDT MAKWNRTRPC KLSEILSLDH DGSAGNKPSQ VEKHTLSELF YDWSIGTRTL
ILWLIWFTGC LGFYTFSLNS VHLGGSEYLN LFLMGVVEIP AYVLVCLGMD RVGRRNILIF
SLLSSAVTSG VIMVIPKDYH VWLVVASMAG KFFIGAAFGL IYLYTAELYP TIVRSLAVGS
GSTVGRVGSI VAPLCIYLSS VWIFMPQLLV GTLALVSGVL TFLLPETLRR PLTTTWEETE
KESSSGKLLS TTSNTVLENV TVENSEDSSL NK
