ID   S22AG_XENLA             Reviewed;         566 AA.
AC   Q66KG0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Solute carrier family 22 member 16;
DE   AltName: Full=Carnitine transporter 2;
DE            Short=CT2;
GN   Name=slc22a16;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: High affinity carnitine transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC       Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
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DR   EMBL; BC080416; AAH80416.1; -; mRNA.
DR   AlphaFoldDB; Q66KG0; -.
DR   SMR; Q66KG0; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..566
FT                   /note="Solute carrier family 22 member 16"
FT                   /id="PRO_0000318993"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        351..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        408..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        436..456
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        468..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        493..513
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        52
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        60
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        112
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        344
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   566 AA;  63754 MW;  E3E5DCC2FAB656C0 CRC64;
     MEHLFDYVGH FGRFQAYLYF ASAFQTISCG IHYLASVFIA VTPKFICRAP GNISTVLLPN
     ASTLRLEDAW ESWTSKDYLV VQQENGDIWE LNQCSRLKRE DASYLTYFYD GNKTLFSCSN
     GYHYDKSNLE SSIVTEWDLV CDREWLAKLI QPIFMLGVLI GAVIFGDIAD RVGRRPIIWI
     TSTGQFLFGI AVAFTFDYYS FVIVRFLLAM VSSGYYVVVF VYLTEYVGIK ARTWASMHVH
     AFFAVGVMIV SLVGFLVRTW WIYQIILSLT TLPFVLCCWM LPETPFWLYS QGKYKEVEKL
     IRTIEKWNKI STPCKLSELC PAQETHVDQP NTLKNHNVLD LFYNWSFARR TITVWLIWFT
     GSLGYYVFAL NSVNLGGNEY LNLFLTGAVE IPSYIVACLG MDKIGRRNTL APFLIISAVI
     CGVIMLIPQD HSTVTIAMSM AGKFSIAVAF GLIYLYTAEL YPTIVRSLAV GSGSMMCRIG
     SVVAPFCVYL TDVWIFMPQM LVGIMAFLTG ILTLTLPETL GIPLTSTMEE AAEMGTTSGI
     TKRKALTESN GVVMEKLDQT TDNAAS