S22AH_BOVIN
ID S22AH_BOVIN Reviewed; 567 AA.
AC Q3SZQ2;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Solute carrier family 22 member 17;
DE AltName: Full=24p3 receptor;
DE Short=24p3R;
DE AltName: Full=Lipocalin-2 receptor;
GN Name=SLC22A17;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Uterus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cell surface receptor for LCN2 (24p3) that plays a key role
CC in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-
CC 24p3), followed by internalization of holo-24p3 and release of iron,
CC thereby increasing intracellular iron concentration and leading to
CC inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed
CC by internalization of apo-24p3 and its association with an
CC intracellular siderophore, leading to iron chelation and iron transfer
CC to the extracellular medium, thereby reducing intracellular iron
CC concentration and resulting in apoptosis (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Vacuole membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Note=Upon LCN2-binding, it is
CC internalized. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
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DR EMBL; BC102752; AAI02753.2; -; mRNA.
DR RefSeq; NP_001124227.1; NM_001130755.2.
DR RefSeq; XP_010807280.1; XM_010808978.2.
DR AlphaFoldDB; Q3SZQ2; -.
DR SMR; Q3SZQ2; -.
DR STRING; 9913.ENSBTAP00000036264; -.
DR PaxDb; Q3SZQ2; -.
DR PRIDE; Q3SZQ2; -.
DR Ensembl; ENSBTAT00000036406; ENSBTAP00000036264; ENSBTAG00000016467.
DR GeneID; 539848; -.
DR KEGG; bta:539848; -.
DR CTD; 51310; -.
DR VEuPathDB; HostDB:ENSBTAG00000016467; -.
DR VGNC; VGNC:34725; SLC22A17.
DR eggNOG; KOG0255; Eukaryota.
DR GeneTree; ENSGT00940000160959; -.
DR HOGENOM; CLU_001265_33_6_1; -.
DR InParanoid; Q3SZQ2; -.
DR OMA; HHVIYSS; -.
DR OrthoDB; 1032137at2759; -.
DR TreeFam; TF335753; -.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000016467; Expressed in floor plate of diencephalon and 103 other tissues.
DR ExpressionAtlas; Q3SZQ2; baseline and differential.
DR GO; GO:0031301; C:integral component of organelle membrane; ISS:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; ISS:UniProtKB.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0015891; P:siderophore transport; ISS:UniProtKB.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Ion transport; Iron; Iron transport; Membrane;
KW Receptor; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport; Vacuole.
FT CHAIN 1..567
FT /note="Solute carrier family 22 member 17"
FT /id="PRO_0000398632"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 350..369
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 444..464
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 475..495
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 502..522
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 545..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 70
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 79
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 567 AA; 60174 MW; 963A0EBC3DCAEE8A CRC64;
MGSSLSLAVP PGPLSFEALL AQVGALGGGQ QLQLGLCCLP VLFVALGLAS DPIFTLAPPL
HCHYGAFPPN ASGWEQPPNA SGVSVASAAL AASAASRLAT STDPSCSGFA PPDFNHCLKD
WDYNGLPVLT TNAIGQWDLV CDLGWQVILE QILFILGFAS GYLFLGYPAD RFGRRGIVLL
TLGLVGPCGV GGAAAGSSTG VMALRFLLGF LLAGVDLGVY LMRLELCDPT QRLRVALAGE
LVGVGGHFLF LGLALVSKDW RFLQRMITAP CILFLFYGWP GLFLESARWL IVKRQIEEAQ
SVLRILAERN RPHGQMLGEE AQEALQDLEN TCPLPATSSF SFASLLNYRN IWKNLLILGF
TNFIAHAIRH CYQPVGGGGS PSDFYLCSLL ASGTAALACV FLGVTVDRFG RRGILLLSMT
LTGIASLALL GLWDYLNEAA ITTFSVLGLF SSQAAGILST LLAAEVIPTT VRGRGLGLIM
ALGALGGLSG PAQRLHMGHG AFLQHVVLAA CALLCILSIM LLPETKRKLL PEVLRDGELC
RRPSLLQQPP PNRCDHVPLL ATPNPAL
